CALCB - calcitonin related polypeptide beta Gene

Homo sapiens

Also known as CALC2; CGRP2; CGRP-II

Gene ID: 797 | Gene type: protein coding

About CALCB

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:15,073,593-15,078,637 (from NCBI)

This gene has 3 transcripts (splice variants), 227 orthologues and 2 paralogues. Restricted expression toward thyroid (RPKM 12.3).

Summary

Predicted to enable Calcitonin receptor binding activity. Predicted to be involved in adenylate cyclase-activating G protein-coupled receptor signaling pathway and regulation of cytosolic calcium ion concentration. Predicted to be located in extracellular region. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

CALCB Products(1)

mRNA	Protein	Name
NM_000728.4	NP_000719.1	calcitonin gene-related peptide 2 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CALCB Protein Structure

Calc_CGRP_IAPP

0
100
127 a.a.

Protein Preferred Names

Protein Names

calcitonin gene-related peptide 2

beta-CGRP

CALCB Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CALCB	P10092	CIB1	Homo sapiens	Q99828	Y2H Prey Pooling	32296183
Intra	CALCB	P10092	CIB1	Homo sapiens	Q99828	Validated Y2H	32296183
Intra	CALCB	P10092	CIB1	Homo sapiens	Q99828	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CALCB Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7706	CALCB Protein, Human (HEK293, hFc)	P10092 (A26-F118)	≥95%
HY-P75600	CALCB Protein, Human (HEK293, mFc)	P10092 (A26-F118)	≥95%

Related Diseases

Diseases

Alias

Immunodeficiency 17

IMD17	Cd3-Gamma Deficiency
Scid-Like Immunodeficiency, T Cell-Partial, B Cell-Positive, Nk Cell-Positive	Combined Immunodeficiency Due To Cd3gamma Deficiency
Immunodeficiency 17, Cd3 Gamma Deficient	Cd3gamma Deficiency
Immunodeficiency, Type 17

Thyroid Carcinoma, Familial Medullary

Medullary Thyroid Carcinoma	Familial Medullary Thyroid Carcinoma
MTC	Medullary Thyroid Cancer
Fmtc	Mtc1
Thyroid Cancer, Medullary	Thyroid Carcinoma, Medullary
Familial Mtc	Thyroid Carcinoma Medullary
Carcinoma, Thyroid, Medullary, Familial	Medullary Carcinoma Of Thyroid
Medullary Carcinoma With Amyloid Stroma, Unspecified Site	Medullary Carcinoma With Amyloid Stroma Of Thyroid

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01829	CALCB Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	CALCB	RGD	RGD:620997
Macaca mulatta	CALCB	VGNC	VGNC:70515
Mus musculus	CALCB	MGD	MGI:2151254
Others	CALCB	NCBI

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