ASB13 - ankyrin repeat and SOCS box containing 13 Gene

Homo sapiens

Gene ID: 79754 | Gene type: protein coding

About ASB13

Cytogenetic location: 10p15.1 Genomic coordinates (GRCh38): 10:5,638,867-5,666,595 (from NCBI)

This gene has 5 transcripts (splice variants) and 234 orthologues. Ubiquitous expression in kidney (RPKM 21.1), small intestine (RPKM 13.2) and 25 other tissues.

Summary

The protein encoded by this gene is a member of the ankyrin repeat and SOCS box-containing (ASB) family of proteins. They contain ankyrin repeat sequence and a SOCS box domain. The SOCS box serves to couple suppressor of cytokine signalling (SOCS) proteins and their binding partners with the elongin B and C complex, possibly targeting them for degradation. Multiple alternatively spliced transcript variants, both protein-coding and not protein-coding, have been described for this gene. [provided by RefSeq, Nov 2010]

ASB13 Products(1)

mRNA	Protein	Name
NM_024701.4	NP_078977.2	ankyrin repeat and SOCS box protein 13

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16169070	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ASB13 Protein Structure

Ank_2

Ank

SOCS_box

0
100
200
278 a.a.

Protein Preferred Names

Protein Names

ankyrin repeat and SOCS box protein 13

ankyrin repeat domain-containing SOCS box protein Asb-13

ASB13 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ASB13	Q8WXK3	ZMIZ2	Homo sapiens	Q8NF64-2	Validated Y2H	25416956
Intra	ASB13	Q8WXK3	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Array	25416956
Intra	ASB13	Q8WXK3	ZMIZ2	Homo sapiens	Q8NF64-2	Y2H Prey Pooling	25416956
Intra	ASB13	Q8WXK3	VAC14	Homo sapiens	Q08AM6	Y2H Prey Pooling	25416956
Intra	ASB13	Q8WXK3	VAC14	Homo sapiens	Q08AM6	Y2H Array	25416956
Intra	ASB13	Q8WXK3	VAC14	Homo sapiens	Q08AM6	Y2H Array	29892012
Intra	ASB13	Q8WXK3	MARK3	Homo sapiens	P27448	Anti Tag CoIP	16169070
Intra	ASB13	Q8WXK3	HIF1AN	Homo sapiens	Q9NWT6	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ASB13 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P7511	ASB13 Protein, Human (His)	Q8WXK3-1 (M1-N278)	≥95%

Related Diseases

Diseases

Alias

Body Dysmorphic Disorder

Dysmorphophobia	Body Dysmorphia
Dysmorphic Syndrome	Body Dysmorphic Disorders

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01062	ASB13 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ASB13	VGNC	VGNC:69865
Rattus norvegicus	ASB13	RGD	RGD:1310387
Canis familiaris	ASB13	VGNC	VGNC:52211
Bos taurus	ASB13	VGNC	VGNC:26190
Mus musculus	ASB13	MGD	MGI:2145525
Felis catus	ASB13	VGNC	VGNC:59958
Others	ASB13	NCBI

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