HIF1AN - hypoxia inducible factor 1 subunit alpha inhibitor Gene

Homo sapiens

Also known as FIH1

Gene ID: 55662 | Gene type: protein coding

About HIF1AN

Cytogenetic location: 10q24.31 Genomic coordinates (GRCh38): 10:100,535,943-100,559,998 (from NCBI)

This gene has 5 transcripts (splice variants), 212 orthologues and 4 paralogues. Ubiquitous expression in testis (RPKM 12.2), skin (RPKM 8.6) and 25 other tissues.

Summary

Enables several functions, including 2-oxoglutarate-dependent dioxygenase activity; NF-kappaB binding activity; and transition metal ion binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter in response to hypoxia; and protein hydroxylation. Located in cytosol; nucleoplasm; and perinuclear region of cytoplasm. Colocalizes with nucleus. [provided by Alliance of Genome Resources, Apr 2022]

HIF1AN Products(1)

mRNA	Protein	Name
NM_017902.3	NP_060372.2	hypoxia-inducible factor 1-alpha inhibitor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables NF-kappaB binding	IPI IPI: Inferred from physical interaction	17003112	GOA
enables Notch binding	IPI IPI: Inferred from physical interaction	17573339	GOA
enables [protein]-asparagine 3-dioxygenase activity	IDA IDA: Inferred from direct assay	12080085	GOA
enables [protein]-asparagine 3-dioxygenase activity	IMP IMP: Inferred from mutant phenotype	19245366	GOA
enables ankyrin repeat binding	IPI IPI: Inferred from physical interaction	17003112	GOA
enables carboxylic acid binding	IDA IDA: Inferred from direct assay	17135241	GOA
enables ferrous iron binding	IDA IDA: Inferred from direct assay	12446723	GOA
enables peptidyl-aspartic acid 3-dioxygenase activity	IDA IDA: Inferred from direct assay	21177872	GOA
enables peptidyl-histidine dioxygenase activity	IDA IDA: Inferred from direct assay	21251231	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11641274	GOA
enables protein homodimerization activity	IDA IDA: Inferred from direct assay	12446723	GOA
enables transcription corepressor activity	IDA IDA: Inferred from direct assay	11641274	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	12446723	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of Notch signaling pathway	IDA IDA: Inferred from direct assay	18299578	GOA
involved in positive regulation of myoblast differentiation	IMP IMP: Inferred from mutant phenotype	18299578	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	14734545	GOA
colocalizes with nucleus	IDA IDA: Inferred from direct assay	18299578	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	19726677	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HIF1AN Protein Structure

Cupin_8

0
100
200
300
349 a.a.

Protein Preferred Names

Protein Names

hypoxia-inducible factor 1-alpha inhibitor

FIH-1

HIF1AN Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	HIF1AN	Q9NWT6	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	28514442
Intra	HIF1AN	Q9NWT6	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	26752685
Intra	HIF1AN	Q9NWT6	OTUB1	Homo sapiens	Q96FW1	Hydroxylase Assay	26752685
Intra	HIF1AN	Q9NWT6	OTUB1	Homo sapiens	Q96FW1	Anti Tag CoIP	33961781
Intra	HIF1AN	Q9NWT6	TNKS	Homo sapiens	O95271	Enzymatic Study	21251231
Intra	HIF1AN	Q9NWT6	TNKS	Homo sapiens	O95271	Anti Tag CoIP	28514442
Intra	HIF1AN	Q9NWT6	TNKS	Homo sapiens	O95271	Hydroxylase Assay	17003112
Intra	HIF1AN	Q9NWT6	TNKS	Homo sapiens	O95271	Anti Tag CoIP	33961781
Intra	HIF1AN	Q9NWT6	TNKS	Homo sapiens	O95271	Anti Tag CoIP	26972000
Intra	HIF1AN	Q9NWT6	ANKRD50	Homo sapiens	Q9ULJ7-2	Validated Y2H	32296183
Intra	HIF1AN	Q9NWT6	NFKB1	Homo sapiens	P19838	Y2H	17003112
Intra	HIF1AN	Q9NWT6	NFKB1	Homo sapiens	P19838	Hydroxylase Assay	17003112
Intra	HIF1AN	Q9NWT6	NFKB1	Homo sapiens	P19838	Decarboxylation	17003112
Intra	HIF1AN	Q9NWT6	NFKB1	Homo sapiens	P19838	Anti Tag CoIP	17003112
Intra	HIF1AN	Q9NWT6	NFKBIA	Homo sapiens	P25963	Anti Bait CoIP	17003112
Intra	HIF1AN	Q9NWT6	NFKBIA	Homo sapiens	P25963	Anti Tag CoIP	26972000
Intra	HIF1AN	Q9NWT6	NFKBIA	Homo sapiens	P25963	Hydroxylase Assay	17003112
Intra	HIF1AN	Q9NWT6	FEM1B	Homo sapiens	Q9UK73	Anti Tag CoIP	17003112
Intra	HIF1AN	Q9NWT6	FEM1B	Homo sapiens	Q9UK73	Y2H	17003112
Intra	HIF1AN	Q9NWT6	FEM1B	Homo sapiens	Q9UK73	Hydroxylase Assay	17003112
Intra	HIF1AN	Q9NWT6	UACA	Homo sapiens	Q9BZF9	Y2H	17003112
Intra	HIF1AN	Q9NWT6	UACA	Homo sapiens	Q9BZF9	Anti Tag CoIP	17003112
Intra	HIF1AN	Q9NWT6	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	33961781
Intra	HIF1AN	Q9NWT6	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	26972000
Intra	HIF1AN	Q9NWT6	TNKS2	Homo sapiens	Q9H2K2	Anti Tag CoIP	28514442
Intra	HIF1AN	Q9NWT6	TNKS2	Homo sapiens	Q9H2K2	Enzymatic Study	21251231
Intra	HIF1AN	Q9NWT6	RIPK4	Homo sapiens	P57078	Anti Tag CoIP	26972000
Intra	HIF1AN	Q9NWT6	HIF1A	Homo sapiens	Q16665	Hydroxylase Assay	17003112
Intra	HIF1AN	Q9NWT6	HIF1A	Homo sapiens	Q16665	Decarboxylation	17003112
Intra	HIF1AN	Q9NWT6	HIF1A	Homo sapiens	Q16665	Hydroxylase Assay	26752685
Intra	HIF1AN	Q9NWT6	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	26972000
Intra	HIF1AN	Q9NWT6	HIF1A	Homo sapiens	Q16665	X-Ray Diffraction	12446723
Intra	HIF1AN	Q9NWT6	HIF1A	Homo sapiens	Q16665	Anti Tag CoIP	26751287
Intra	HIF1AN	Q9NWT6	APBA3	Homo sapiens	O96018	Anti Tag CoIP	29426014
Intra	HIF1AN	Q9NWT6	APBA3	Homo sapiens	O96018	Anti Tag CoIP	33961781
Intra	HIF1AN	Q9NWT6	APBA3	Homo sapiens	O96018	Anti Tag CoIP	26948053
Intra	HIF1AN	Q9NWT6	APBA3	Homo sapiens	O96018	Anti Tag CoIP	28514442
Intra	HIF1AN	Q9NWT6	APBA3	Homo sapiens	O96018	Anti Bait CoIP	26948053
Intra	HIF1AN	Q9NWT6	ASB13	Homo sapiens	Q8WXK3	Anti Tag CoIP	26972000
Intra	HIF1AN	Q9NWT6	ASB13	Homo sapiens	Q8WXK3	Y2H Pooling	16189514
Intra	HIF1AN	Q9NWT6	ASB9	Homo sapiens	Q96DX5	Y2H Pooling	16189514
Intra	HIF1AN	Q9NWT6	ILK	Homo sapiens	Q13418	Anti Tag CoIP	26972000
Intra	HIF1AN	Q9NWT6	ILK	Homo sapiens	Q13418	Hydroxylase Assay	17003112
Intra	HIF1AN	Q9NWT6	PSMD10	Homo sapiens	O75832	Hydroxylase Assay	17003112
Intra	HIF1AN	Q9NWT6	PSMD10	Homo sapiens	O75832	Anti Tag CoIP	26972000
Intra	HIF1AN	Q9NWT6	ANKRD49	Homo sapiens	Q8WVL7	Hydroxylase Assay	17003112
Intra	HIF1AN	Q9NWT6	ANKRD49	Homo sapiens	Q8WVL7	Anti Tag CoIP	29426014
Intra	HIF1AN	Q9NWT6	ANKRD49	Homo sapiens	Q8WVL7	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Erythrocytosis, Familial, 4

ECYT4	Familial Erythrocytosis 4
Erythrocytosis, Familial, Type 4

Erythrocytosis, Familial, 5

ECYT5

Familial Erythrocytosis 5

Glioblastoma

Glioblastoma Multiforme	Gbm
Adult Glioblastoma Multiforme	Grade Iv Adult Astrocytic Tumor
Primary Glioblastoma Multiforme	Spongioblastoma Multiforme
Adult Glioblastoma	Primary Glioblastoma

Erythrocytosis, Familial, 2

Chuvash Polycythemia	ECYT2
Familial Erythrocytosis 2	Autosomal Recessive Benign Erythrocytosis
Polycythemia, Vhl-Dependent	Chuvash Erythromatosis
Chuvash Type Polycythemia	Chuvash Erythrocytosis
Von Hippel-Lindau-Dependent Polycythemia	Polycythemia Chuvash Type
Vhl-Dependent Polycythemia	Erythrocytosis, Familial, Type 2

Renal Cell Carcinoma, Nonpapillary

Renal Cell Carcinoma	RCC
Nonpapillary Renal Cell Carcinoma	Clear Cell Renal Cell Carcinoma
Hypernephroma	Adenocarcinoma Of Kidney
Renal Carcinoma, Chromophobe, Somatic	Clear Cell Carcinoma Of Kidney
Clear-Cell Metastatic Renal Cell Carcinoma	Clear Cell Renal Carcinoma
Renal Cell Carcinoma, Somatic	Conventional Renal Cell Carcinoma
Conventional Renal Cell Carcinoma	Renal Clear Cell Carcinoma
Ccrcc	Hereditary Clear Cell Renal Cell Carcinoma
Carcinoma, Renal Cell	Renal Cell Carcinoma, Clear Cell, Somatic
Renal Cell Carcinoma, Clear Cell	Clear Cell Kidney Carcinoma
Clear Cell Rcc	Cystic-Multilocular Variant
Clear Cell Renal Cell Adenocarcinoma	Hereditary Clear Cell Renal Cell Adenocarcinoma
Common Renal Cell Carcinoma	Crcc
Renal Cell Carcinoma Non-Papillary	Carcinoma Renal Cell
Renal Cell Cancer	Carcinoma, Renal Cell, Nonpapillary

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06169	HIF1AN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	HIF1AN	RGD	RGD:1308281
Felis catus	HIF1AN	VGNC	VGNC:97455
Canis familiaris	HIF1AN	VGNC	VGNC:41687
Mus musculus	HIF1AN	MGD	MGI:2442345
Bos taurus	HIF1AN	VGNC	VGNC:29849
Macaca mulatta	HIF1AN	VGNC	VGNC:81417

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