MICALL2 - MICAL like 2 Gene

Homo sapiens

Also known as JRAB; MICAL-L2

Gene ID: 79778 | Gene type: protein coding

About MICALL2

This gene has 15 transcripts (splice variants), 255 orthologues and 7 paralogues. Broad expression in spleen (RPKM 13.4), small intestine (RPKM 10.9) and 23 other tissues.

Summary

Enables filamin binding activity. Involved in positive regulation of protein targeting to mitochondrion. Predicted to be located in several cellular components, including bicellular tight junction; neuron projection; and recycling endosome. Predicted to colocalize with stress fiber. [provided by Alliance of Genome Resources, Apr 2022]

MICALL2 Products(1)

mRNA	Protein	Name
NM_182924.4	NP_891554.1	MICAL-like protein 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables filamin binding	IDA IDA: Inferred from direct assay	23890175	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MICALL2 Protein Structure

LIM

DUF3585

0
200
400
600
800
904 a.a.

Protein Preferred Names

Protein Names

MICAL-like protein 2

junctional Rab13-binding protein

MICALL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MICALL2	Q8IY33	DCDC2	Homo sapiens	Q9UHG0	Validated Y2H	32296183
Intra	MICALL2	Q8IY33	DCDC2	Homo sapiens	Q9UHG0	Y2H Prey Pooling	32296183
Intra	MICALL2	Q8IY33	DCDC2	Homo sapiens	Q9UHG0	Y2H Array	32296183
Intra	MICALL2	Q8IY33	CDR2	Homo sapiens	Q01850	Y2H Prey Pooling	32296183
Intra	MICALL2	Q8IY33	CDR2	Homo sapiens	Q01850	Validated Y2H	32296183
Intra	MICALL2	Q8IY33	CDR2	Homo sapiens	Q01850	Y2H Array	32296183
Intra	MICALL2	Q8IY33	ACTN3	Homo sapiens	Q08043	Y2H Array	32296183
Intra	MICALL2	Q8IY33	ACTN3	Homo sapiens	Q08043	Y2H Prey Pooling	32296183
Intra	MICALL2	Q8IY33	ACTN4	Homo sapiens	O43707	Y2H Prey Pooling	32296183
Intra	MICALL2	Q8IY33	ACTN4	Homo sapiens	O43707	Y2H Array	32296183
Intra	MICALL2	Q8IY33	ACTN1	Homo sapiens	P12814	Y2H Array	32296183
Intra	MICALL2	Q8IY33	ACTN1	Homo sapiens	P12814	Y2H Prey Pooling	25416956
Intra	MICALL2	Q8IY33	ACTN1	Homo sapiens	P12814	Y2H Prey Pooling	32296183
Intra	MICALL2	Q8IY33	ACTN1	Homo sapiens	P12814	Validated Y2H	25416956
Intra	MICALL2	Q8IY33	ACTN2	Homo sapiens	P35609	Y2H Array	31515488
Intra	MICALL2	Q8IY33	ACTN2	Homo sapiens	P35609	Validated Y2H	25416956
Intra	MICALL2	Q8IY33	ACTN2	Homo sapiens	P35609	Y2H Prey Pooling	32296183
Intra	MICALL2	Q8IY33	ACTN2	Homo sapiens	P35609	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Joubert Syndrome 1

Joubert Syndrome	Jbts
Cerebellooculorenal Syndrome 1	JBTS1
Joubert-Boltshauser Syndrome	Cerebelloparenchymal Disorder Iv
Cpd4	Cors1
Joubert Syndrome And Related Disorders	Jsrd
Familial Aplasia Of The Vermis	Joubert Syndrome Related Disorders
Js	Cerebellar Vermis Agenesis
Cerebelloparenchymal Disorder 4	Agenesis Of Cerebellar Vermis
Cerebello-Oculo-Renal Syndrome	Cors
Joubert-Bolthauser Syndrome	Cpd Iv
Classic Joubert Syndrome	Joubert Syndrome Type A
Pure Joubert Syndrome	Cerebello-Oculo-Renal Syndrome 1
Joubert Syndrome-1	Joubert Syndrome, Type 1
Joubert'S Syndrome

Dermatomycosis

Dermatomycoses

Dyschromatosis Universalis Hereditaria

Duh

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08429	MICALL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	MICALL2	VGNC	VGNC:31460
Mus musculus	MICALL2	MGD	MGI:2444818
Macaca mulatta	MICALL2	VGNC	VGNC:74620
Canis familiaris	MICALL2	VGNC	VGNC:54329
Rattus norvegicus	MICALL2	RGD	RGD:1307875
Felis catus	MICALL2	VGNC	VGNC:80593

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