KDM8 - lysine demethylase 8 Gene

Homo sapiens

Also known as JMJD5

Gene ID: 79831 | Gene type: protein coding

About KDM8

Cytogenetic location: 16p12.1 Genomic coordinates (GRCh38): 16:27,203,526-27,221,768 (from NCBI)

This gene has 14 transcripts (splice variants), 205 orthologues and 4 paralogues. Broad expression in liver (RPKM 13.5), small intestine (RPKM 5.4) and 18 other tissues.

Summary

This gene likely encodes a histone lysine demethylase. Studies of a similar protein in mouse indicate a potential role for this protein as a tumor suppressor. Alternatively spliced transcript variants have been described.[provided by RefSeq, Feb 2009]

KDM8 Products(2)

mRNA	Protein	Name
NM_001145348.2	NP_001138820.1	bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 1
NM_024773.3	NP_079049.2	bifunctional peptidase and arginyl-hydroxylase JMJD5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables aminopeptidase activity	IDA IDA: Inferred from direct assay	28847961	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	20457893	GOA
enables endopeptidase activity	IDA IDA: Inferred from direct assay	28847961	GOA
enables histone H3K36 demethylase activity	IDA IDA: Inferred from direct assay	20457893	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	28847961	GOA
enables peptidyl-arginine 3-dioxygenase activity	EXP EXP: Inferred from Experiment	29563586	GOA
enables peptidyl-arginine 3-dioxygenase activity	IDA IDA: Inferred from direct assay	29563586	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	24981860	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in G2/M transition of mitotic cell cycle	IMP IMP: Inferred from mutant phenotype	20457893	GOA
involved in negative regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	30500822	GOA
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	20457893	GOA
involved in protein destabilization	IMP IMP: Inferred from mutant phenotype	30500822	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	20457893	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KDM8 Protein Structure

Cupin_8

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

bifunctional peptidase and arginyl-hydroxylase JMJD5

JmjC arginyl-hydroxylase

KDM8 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KDM8	Q8N371	RCCD1	Homo sapiens	A6NED2	Anti Bait CoIP	24981860

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Glycogen Storage Disease Xv

GSD15	Gsd Xv
Glycogenin Deficiency	Gyg1 Deficiency
Glycogen Storage Disease Type Xv	Glycogen Storage Disease With Severe Cardiomyopathy Due To Glycogenin Deficiency
Gsd Type 15	Gsd Type Xv
Gsd With Severe Cardiomyopathy Due To Glycogenin Deficiency	Glycogen Storage Disease Type 15
Glycogenosis Type 15	Glycogenosis Type Xv
Glycogenosis With Severe Cardiomyopathy Due To Glycogenin Deficiency	Glycogen Storage Disease 15
Storage Disease, Glycogen, Type Xv

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07225	KDM8 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KDM8	VGNC	VGNC:80586
Mus musculus	KDM8	MGD	MGI:1924285
Bos taurus	KDM8	VGNC	VGNC:30534
Canis familiaris	KDM8	VGNC	VGNC:42330
Macaca mulatta	KDM8	VGNC	VGNC:81426
Rattus norvegicus	KDM8	RGD	RGD:1304823
Others	KDM8	NCBI

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