ZDHHC11 - zinc finger DHHC-type containing 11 Gene

Homo sapiens

Also known as ZNF399

Gene ID: 79844 | Gene type: protein coding

About ZDHHC11

This gene has 12 transcripts (splice variants), 175 orthologues and 17 paralogues. Broad expression in lung (RPKM 2.8), duodenum (RPKM 2.5) and 24 other tissues.

Summary

Enables signaling adaptor activity. Involved in Antiviral innate immune response and positive regulation of defense response to virus by host. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Apr 2022]

ZDHHC11 Products(2)

mRNA	Protein	Name
NM_001393492.1	NP_001380421.1	palmitoyltransferase ZDHHC11 isoform 1
NM_024786.3	NP_079062.1	palmitoyltransferase ZDHHC11 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	29429998	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	29429998	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in antiviral innate immune response	IMP IMP: Inferred from mutant phenotype	29429998	GOA
involved in positive regulation of defense response to virus by host	IMP IMP: Inferred from mutant phenotype	29429998	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	16647879	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ZDHHC11 Protein Structure

DHHC

0
100
200
300
412 a.a.

Protein Preferred Names

Protein Names

palmitoyltransferase ZDHHC11

DHHC-11

ZDHHC11 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ZDHHC11	Q9H8X9	TMEM14B	Homo sapiens	Q9NUH8	Validated Y2H	32296183
Intra	ZDHHC11	Q9H8X9	TMEM14B	Homo sapiens	Q9NUH8	Y2H Array	32296183
Intra	ZDHHC11	Q9H8X9	TMEM14B	Homo sapiens	Q9NUH8	Y2H Prey Pooling	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Burkitt Lymphoma

Burkitt'S Lymphoma	BL
Burkitt Lymphoma, Somatic	Burkitt Lymphoma/Leukaemia
Burkitt'S Tumor	Burkitt'S Tumor Or Lymphoma
Malignant Lymphoma, Burkitt'S Type	Small Non-Cleaved Cell Lymphoma, Burkitt'S Type
Small Non-Cleaved Cell Lymphoma	Burkitt Tumor
Burkitts Lymphoma	Lymphoma, Small Noncleaved-Cell
Burkitt Tumour	Diffuse Small Noncleaved Malignant Burkitt Lymphoma
Malignant Burkitt Lymphoma	“Burkitt-Like” Lymphoma
Undifferentiated Burkitt Lymphoma	Small Noncleaved Cell Burkitt Lymphoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS16012	ZDHHC11 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	ZDHHC11	RGD	RGD:1564281
Mus musculus	ZDHHC11	MGD	MGI:1918414

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