2. Gene
  3. BORA - BORA aurora kinase A activator Gene

BORA - BORA aurora kinase A activator Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as C13orf34

Gene ID: 79866 | Gene type: protein coding

About BORA

Cytogenetic location: 13q21.33 Genomic coordinates (GRCh38): 13:72,727,923-72,756,196 (from NCBI)

This gene has 9 transcripts (splice variants) and 199 orthologues. Ubiquitous expression in lymph node (RPKM 4.2), appendix (RPKM 3.1) and 24 other tissues.

Summary

BORA is an activator of the protein kinase Aurora A (AURKA; MIM 603072), which is required for centrosome maturation, spindle assembly, and asymmetric protein localization during mitosis (Hutterer et al., 2006 [PubMed 16890155]).[supplied by OMIM, Mar 2008]

BORA Products(4)

mRNA Protein Name
NM_001286746.3 NP_001273675.2 protein aurora borealis isoform 1
NM_001286747.2 NP_001273676.1 protein aurora borealis isoform 3
NM_001366664.2 NP_001353593.1 protein aurora borealis isoform 4
NM_024808.5 NP_079084.4 protein aurora borealis isoform 1
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
16890155 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
18521620 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of mitotic nuclear division IMP
IMP: Inferred from mutant phenotype
18521620 GOA
involved in regulation of mitotic spindle organization IMP
IMP: Inferred from mutant phenotype
18521620 GOA
involved in regulation of protein localization IMP
IMP: Inferred from mutant phenotype
18521620 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

BORA Protein Structure

BORA_N

BORA_N: Protein aurora borealis N-terminus (1 - 205)

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  • 559 a.a.
Protein Preferred Names Protein Names

protein aurora borealis

Related Diseases

Diseases Alias
Papillary Transitional Carcinoma

Papillary Transitional Cell Carcinoma
T2-Low Asthma

Type 2 Low Endotype
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-D1486 4,4-Difluoro-8-(4'-iodophenyl)-1,7-bis-(1'-napthyl)-4-bora-3alpha,4alpha-diaza-s-indacene / Unkown
HY-RS01577 BORA Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta BORA VGNC VGNC:70376
Canis familiaris BORA VGNC VGNC:38499
Rattus norvegicus BORA RGD RGD:1309522
Bos taurus BORA VGNC VGNC:26541
Felis catus BORA VGNC VGNC:60150
Mus musculus BORA MGD MGI:1924994