ATAT1 - alpha tubulin acetyltransferase 1 Gene

Homo sapiens

Also known as TAT; MEC17; C6orf134; Nbla00487; alpha-TAT; alpha-TAT1

Gene ID: 79969 | Gene type: protein coding

About ATAT1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:30,626,874-30,646,821 (from NCBI)

This gene has 11 transcripts (splice variants), 1 gene allele and 191 orthologues. Ubiquitous expression in brain (RPKM 7.7), testis (RPKM 3.5) and 23 other tissues.

Summary

This gene encodes a protein that localizes to clathrin-coated pits, where it acetylates alpha tubulin on lysine 40. This process may be important in microtubule growth, for instance during chemotaxis and the formation of cilium. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

ATAT1 Products(7)

mRNA	Protein	Name
NM_001031722.4	NP_001026892.1	alpha-tubulin N-acetyltransferase 1 isoform 1 precursor
NM_001190724.4	NP_001177653.1	alpha-tubulin N-acetyltransferase 1 isoform 3 precursor
NM_001254952.4	NP_001241881.1	alpha-tubulin N-acetyltransferase 1 isoform 4
NM_001318762.3	NP_001305691.1	alpha-tubulin N-acetyltransferase 1 isoform 5
NM_001318763.3	NP_001305692.1	alpha-tubulin N-acetyltransferase 1 isoform 6
NM_001413067.1	NP_001399996.1	alpha-tubulin N-acetyltransferase 1 isoform 7
NM_024909.5	NP_079185.2	alpha-tubulin N-acetyltransferase 1 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	EXP EXP: Inferred from Experiment	23071318	GOA
enables lysine N-acetyltransferase activity, acting on acetyl phosphate as donor	IDA IDA: Inferred from direct assay	24906155	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	36931259	GOA
enables tubulin N-acetyltransferase activity	IDA IDA: Inferred from direct assay	23071314	GOA
enables tubulin N-acetyltransferase activity	IMP IMP: Inferred from mutant phenotype	20829795	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within alpha-tubulin acetylation	IDA IDA: Inferred from direct assay	23071314	GOA
involved in alpha-tubulin acetylation	IDA IDA: Inferred from direct assay	24906155	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitotic spindle	IDA IDA: Inferred from direct assay	23720746	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATAT1 Protein Structure

Acetyltransf_16

0
100
200
300
421 a.a.

Protein Preferred Names

Protein Names

alpha-tubulin N-acetyltransferase 1

acetyltransferase mec-17 homolog

Related Diseases

Diseases

Alias

Spherocytosis, Type 1

Hereditary Spherocytosis Type 1	SPH1
Hs1	Spherocytosis, Hereditary, 1
Sph	Hs
Hereditary Spherocytosis 1	Spherocytosis 1

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01124	ATAT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ATAT1	MGD	MGI:1913869
Felis catus	ATAT1	VGNC	VGNC:59992
Canis familiaris	ATAT1	VGNC	VGNC:38204
Rattus norvegicus	ATAT1	RGD	RGD:1303066
Bos taurus	ATAT1	VGNC	VGNC:26236
Macaca mulatta	ATAT1	VGNC	VGNC:70106

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