MINDY3 - MINDY lysine 48 deubiquitinase 3 Gene

Homo sapiens

Also known as CARP; DERP5; my042; MST126; FAM188A; MSTP126; C10orf97

Gene ID: 80013 | Gene type: protein coding

About MINDY3

Cytogenetic location: 10p13 Genomic coordinates (GRCh38): 10:15,778,174-15,860,507 (from NCBI)

This gene has 6 transcripts (splice variants), 216 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 5.8), adrenal (RPKM 4.8) and 25 other tissues.

Summary

The protein encoded by this gene contains a caspase-associated recruitment domain and may function in Apoptosis. It has been identified as a tumor suppressor in lung and gastric cancers, and a polymorphism in the gene may be associated with gastric Cancer risk. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Dec 2015]

MINDY3 Products(2)

mRNA	Protein	Name
NM_001318330.2	NP_001305259.1	ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform b precursor
NM_024948.4	NP_079224.1	ubiquitin carboxyl-terminal hydrolase MINDY-3 isoform a

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables K48-linked deubiquitinase activity	IDA IDA: Inferred from direct assay	27292798	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	27292798	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	21499297	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MINDY3 Protein Structure

DUF4205

0
100
200
300
400
445 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase MINDY-3

CARD-containing protein

MINDY3 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MINDY3	Q9H8M7	COPS5	Homo sapiens	Q92905	Confocal	21499297

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Pollen Allergy

Hay Fever

Fish Allergy

Allergy To Fish

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08453	MINDY3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	MINDY3	VGNC	VGNC:74811
Mus musculus	MINDY3	MGD	MGI:1914210
Felis catus	MINDY3	VGNC	VGNC:63512
Bos taurus	MINDY3	VGNC	VGNC:31478
Rattus norvegicus	MINDY3	RGD	RGD:1309605
Canis familiaris	MINDY3	VGNC	VGNC:49794

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