1. Gene
  2. COPS5 - COP9 signalosome subunit 5 Gene

COPS5 - COP9 signalosome subunit 5 Gene

Homo sapiens

Also known as CSN5; JAB1; SGN5; MOV-34

Gene ID: 10987 | Gene type: protein coding

About COPS5

Cytogenetic location: 8q13.1 Genomic coordinates (GRCh38): 8:67,043,079-67,062,133 (from NCBI)

This gene has 13 transcripts (splice variants), 224 orthologues and 3 paralogues. Ubiquitous expression in testis (RPKM 37.3), heart (RPKM 32.6) and 25 other tissues.

Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq, Jul 2008]

COPS5 Products(1)

mRNA Protein Name
NM_006837.3 NP_006828.2 COP9 signalosome complex subunit 5
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables metal-dependent deubiquitinase activity IDA
IDA: Inferred from direct assay
19246649 GOA
enables metallopeptidase activity IMP
IMP: Inferred from mutant phenotype
19214193 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
12082530 GOA
Biological Process GO Annotation Evidence Reference Source
involved in exosomal secretion IDA
IDA: Inferred from direct assay
19246649 GOA
involved in negative regulation of apoptotic process IMP
IMP: Inferred from mutant phenotype
20978819 GOA
involved in positive regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
20978819 GOA
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: Inferred from direct assay
16410250 GOA
involved in protein deneddylation IDA
IDA: Inferred from direct assay
19141280 GOA
involved in protein deneddylation IMP
IMP: Inferred from mutant phenotype
19214193 GOA
involved in regulation of IRE1-mediated unfolded protein response IMP
IMP: Inferred from mutant phenotype
15234121 GOA
involved in regulation of JNK cascade IDA
IDA: Inferred from direct assay
16410250 GOA
Cellular Component GO Annotation Evidence Reference Source
part of COP9 signalosome IDA
IDA: Inferred from direct assay
18850735 GOA
part of COP9 signalosome IPI
IPI: Inferred from physical interaction
25043011 GOA
located in chromatin IDA
IDA: Inferred from direct assay
20978819 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
16300740 GOA
located in cytosol IDA
IDA: Inferred from direct assay
20978819 GOA
located in nucleus IDA
IDA: Inferred from direct assay
16300740 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
16300740 GOA
located in synaptic vesicle IDA
IDA: Inferred from direct assay
21102408 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS5 Protein Structure

JAB

JAB: JAB1/Mov34/MPN/PAD-1 ubiquitin protease (54 - 163)

  • 0
  • 100
  • 200
  • 300
  • 334 a.a.
Protein Preferred Names Protein Names

COP9 signalosome complex subunit 5

38 kDa Mov34 homolog

COPS5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
COPS5 Q92905 RNF20 Homo sapiens Q5VTR2
Anti Tag CoIP
19214193
Intra
COPS5 Q92905 OPRM1 Homo sapiens P35372
Y2H
23840749
Intra
COPS5 Q92905 OPRM1 Homo sapiens P35372
Anti Tag CoIP
23840749
Intra
COPS5 Q92905 OPRM1 Homo sapiens P35372
Pull Down
23840749
Intra
COPS5 Q92905 BRSK2 Homo sapiens Q8IWQ3
Pull Down
22609399
Intra
COPS5 Q92905 BRSK2 Homo sapiens Q8IWQ3
Confocal
22609399
Intra
COPS5 Q92905 BRSK2 Homo sapiens Q8IWQ3
Anti Bait CoIP
22609399
Intra
COPS5 Q92905 BRSK2 Homo sapiens Q8IWQ3
Y2H
22609399
Intra
COPS5 Q92905 BRSK2 Homo sapiens Q8IWQ3
Anti Tag CoIP
22609399
Intra
COPS5 Q92905 COPS3 Homo sapiens Q9UNS2
TAP
18850735
Intra
COPS5 Q92905 COPS3 Homo sapiens Q9UNS2
Anti Tag CoIP
19615732
Intra
COPS5 Q92905 COPS3 Homo sapiens Q9UNS2
Anti Tag CoIP
20399188
Intra
COPS5 Q92905 COPS3 Homo sapiens Q9UNS2
TAP
21145461
Intra
COPS5 Q92905 COPS3 Homo sapiens Q9UNS2
Anti Tag CoIP
33961781
Intra
COPS5 Q92905 COPS3 Homo sapiens Q9UNS2
Anti Tag CoIP
28514442
Intra
COPS5 Q92905 SMAD7 Homo sapiens O15105
Confocal
14993265
Intra
COPS5 Q92905 SMAD7 Homo sapiens O15105
Pull Down
14993265
Intra
COPS5 Q92905 SMAD7 Homo sapiens O15105
Anti Tag CoIP
14993265
Intra
COPS5 Q92905 SMAD7 Homo sapiens O15105
Y2H
14993265
Intra
COPS5 Q92905 F2RL1 Homo sapiens P55085
Y2H
16410250
Intra
COPS5 Q92905 F2RL1 Homo sapiens P55085
Anti Bait CoIP
16410250
Intra
COPS5 Q92905 F2RL1 Homo sapiens P55085
Confocal
16410250
Intra
COPS5 Q92905 CUL3 Homo sapiens Q13618
Anti Tag CoIP
33961781
Intra
COPS5 Q92905 CUL3 Homo sapiens Q13618
TAP
21145461
Intra
COPS5 Q92905 CUL3 Homo sapiens Q13618
TAP
18850735
Intra
COPS5 Q92905 CUL3 Homo sapiens Q13618
Anti Tag CoIP
19615732
Intra
COPS5 Q92905 COPS6 Homo sapiens Q7L5N1
Anti Tag CoIP
20399188
Intra
COPS5 Q92905 COPS6 Homo sapiens Q7L5N1
Pull Down
25043011
Intra
COPS5 Q92905 COPS6 Homo sapiens Q7L5N1
TAP
18850735
Intra
COPS5 Q92905 COPS6 Homo sapiens Q7L5N1
Anti Tag CoIP
19615732
Intra
COPS5 Q92905 COPS6 Homo sapiens Q7L5N1
TAP
21145461
Intra
COPS5 Q92905 CDKN1B Homo sapiens P46527
Pull Down
15480426
Intra
COPS5 Q92905 TXN Homo sapiens P10599
Pull Down
15480426
Intra
COPS5 Q92905 TXN Homo sapiens P10599
TAP
21145461
Intra
COPS5 Q92905 TXN Homo sapiens P10599
Anti Bait CoIP
15480426
Intra
COPS5 Q92905 TXN Homo sapiens P10599
FRET
15480426
Intra
COPS5 Q92905 UCHL1 Homo sapiens P09936
Y2H
12082530
Intra
COPS5 Q92905 UCHL1 Homo sapiens P09936
IF
12082530
Intra
COPS5 Q92905 UCHL1 Homo sapiens P09936
Anti Bait CoIP
12082530
Intra
COPS5 Q92905 MINDY3 Homo sapiens Q9H8M7
Anti Tag CoIP
21499297
Intra
COPS5 Q92905 MINDY3 Homo sapiens Q9H8M7
Y2H
21499297
Intra
COPS5 Q92905 GPS1 Homo sapiens Q13098
Anti Tag CoIP
19615732
Intra
COPS5 Q92905 GPS1 Homo sapiens Q13098
Anti Tag CoIP
20399188
Intra
COPS5 Q92905 GPS1 Homo sapiens Q13098
TAP
21145461
Intra
COPS5 Q92905 GPS1 Homo sapiens Q13098
TAP
18850735
Intra
COPS5 Q92905 GPS1 Homo sapiens Q13098
Anti Tag CoIP
33961781
Intra
COPS5 Q92905 GTPBP3 Homo sapiens Q969Y2
Validated Y2H
32296183
Intra
COPS5 Q92905 CCNDBP1 Homo sapiens O95273
Confocal
15887118
Cross: Cross-species interaction Intra: Intraspecies interaction

COPS5 Antibodies

Cat. No. Product Name Application Reactivity
HY-P83414 JAB1 Antibody (YA3159) WB, IHC-P, ICC/IF, IP Human, Mouse, Rat

Related Diseases

Diseases Alias
Maxillary Sinus Adenocarcinoma

Adenocarcinoma Of Maxillary Sinus

Adenocarcinoma Of The Maxillary Sinus

Xeroderma Pigmentosum, Complementation Group E

Xeroderma Pigmentosum V

Xp5

Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

Xpe

Xp, Group E

Xeroderma Pigmentosum, Type 5

Xeroderma Pigmentosum Complementation Group E

XP-E

Xp Group E

Cockayne Syndrome

Cockayne'S Syndrome

Dwarfism-Retinal Atrophy-Deafness Syndrome

Neill-Dingwall Syndrome

Progeria-Like Syndrome

Progeroid Nanism

Cs

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias

Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Hereditary Ataxia

Sca

Spinocerebellar Ataxia

Ataxias Hereditary

Ataxias, Hereditary

Cerebellar Disease

Cerebellar Diseases

Cerebellar Dysfunction

Cerebellar Abnormality

Cerebellar Disorders

Machado-Joseph Disease

SCA3

MJD

Spinocerebellar Ataxia 3

Azorean Disease

Spinocerebellar Ataxia Type 3

Spinocerebellar Atrophy

Azorean Neurologic Disease

Spinopontine Atrophy

Nigrospinodentatal Degeneration

Spinocerebellar Atrophy Iii

Spinocerebellar Atrophy Type 3

Azorean Ataxia

Azorean Disease Of The Nervous System

Machado Disease

Nigro-Spino-Dentatal Degeneration With Nuclear Ophthalmoplegia

Disease, Machado-Joseph

Ataxia, Spinocerebellar

Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour

Retinitis Pigmentosa

RP

Rod-Cone Dystrophy

Autosomal Recessive Retinitis Pigmentosa

Non-Syndromic Retinitis Pigmentosa

Pericentral Pigmentary Retinopathy

Pigmentary Retinopathy

Tapetoretinal Degeneration

Rcd

Retinitis Pigmentosa Autosomal Recessive

ARRP

Retinitis Pigmentosa, Autosomal Recessive

Retinitis Pigmentosa 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus COPS5 VGNC VGNC:61090
Mus musculus COPS5 MGD MGI:1349415
Macaca mulatta COPS5 VGNC VGNC:71317
Bos taurus COPS5 VGNC VGNC:27602
Rattus norvegicus COPS5 RGD RGD:1310301
Canis familiaris COPS5 VGNC VGNC:54110
Others COPS5 NCBI