NR4A3 - nuclear receptor subfamily 4 group A member 3 Gene

Homo sapiens

Also known as CHN; CSMF; NOR1; MINOR

Gene ID: 8013 | Gene type: protein coding

About NR4A3

Cytogenetic location: 9q31.1 Genomic coordinates (GRCh38): 9:99,821,885-99,866,891 (from NCBI)

This gene has 4 transcripts (splice variants), 198 orthologues, 2 paralogues and is associated with 69 phenotypes. Biased expression in adrenal (RPKM 28.0), urinary bladder (RPKM 16.9) and 13 other tissues.

Summary

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcriptional activator. The protein can efficiently bind the NGFI-B Response Element (NBRE). Three different versions of extraskeletal myxoid chondrosarcomas (EMCs) are the result of reciprocal translocations between this gene and other genes. The translocation breakpoints are associated with Nuclear Receptor Subfamily 4, Group A, Member 3 (on chromosome 9) and either Ewing Sarcome Breakpoint Region 1 (on chromosome 22), RNA Polymerase II, TATA Box-Binding Protein-Associated Factor, 68-KD (on chromosome 17), or Transcription factor 12 (on chromosome 15). Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010]

NR4A3 Products(3)

mRNA	Protein	Name
NM_006981.4	NP_008912.2	nuclear receptor subfamily 4 group A member 3 isoform a
NM_173199.4	NP_775291.1	nuclear receptor subfamily 4 group A member 3 isoform c
NM_173200.3	NP_775292.1	nuclear receptor subfamily 4 group A member 3 isoform b

NR4A3 Protein Structure

zf-C4

Hormone_recep

0
100
200
300
400
500
626 a.a.

Protein Preferred Names

Protein Names

nuclear receptor subfamily 4 group A member 3

chondrosarcoma, extraskeletal myxoid, fused to EWS

Related Diseases

Diseases

Alias

Chondrosarcoma, Extraskeletal Myxoid

Extraskeletal Myxoid Chondrosarcoma	Emc
Myxoid Extraosseous Chondrosarcoma

Chondrosarcoma

Cartilaginous Cancer	Chondrosarcoma Of Bone
Primary Chondrosarcoma Of The Bone	CHDSA

Myxoid Chondrosarcoma

Extraosseous Chondrosarcoma

Extraskeletal Myxoid Chondrosarcoma

Sarcoma

Connective And Soft Tissue Neoplasm	Tumor Of Soft Tissue And Skeleton
Sarcomas	Sarcoma - Category

Vulvar Sarcoma

Sarcoma Of Vulva

Vulva Sarcoma

Myoepithelial Carcinoma

Malignant Myoepithelioma

Myoepithelioma Carcinoma

Ewing Sarcoma

Neuroepithelioma	Ewing'S Tumor
Primitive Neuroectodermal Tumor	Ewings Sarcoma
Ewing'S Sarcoma	Peripheral Neuroepithelioma
ES	Ewings Sarcoma-Primitive Neuroectodermal Tumor
Localized Peripheral Primitive Neuroectodermal Tumor	Peripheral Primitive Neuroectodermal Tumor
Ewing Tumor	Sarcoma, Ewing'S
Ewing Family Of Tumors	Extraosseous Ewing Tumor
Askin Tumor	Ewing'S Family Localized Tumor
Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor	Localized Ewing Sarcoma
Localized Ewing'S Sarcoma	Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor
Localized Ewing'S Tumor	Pnet Of Thoracopulmonary Region
Tumor Of The Ewing Family	Skeletal Ewing Sarcoma
Osseous Ewing Sarcoma	Ppnet
Peripheral Pnet	Extraskeletal Ewing Sarcoma
Eoe	Extraosseous Ewing Sarcoma
Extraskeletal Ewing Tumor	Esft
Ewing Sarcoma Family Of Tumors	Pne
Pnet	Pnet Of The Chest Wall
Sarcoma, Ewing	Neuroectodermal Tumors, Primitive, Peripheral
Neuroectodermal Tumor, Primitive	Disorder Of Eye
Askin'S Tumor	Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor
Neuroepithelioma, Peripheral

Parachordoma

Bone Chondrosarcoma

Acinar Cell Carcinoma

Acinic Cell Carcinoma	Acinic Cell Tumor
Carcinoma Acinar Cell	Carcinoma, Acinar Cell
Acinar Cell Tumor

Sweat Gland Benign Neoplasm

Neoplasm Of Sweat Gland	Sweat Gland Tumor
Tumor Of The Sweat Gland	Sweat Gland Neoplasms
Sweat Gland Neoplasm

Myxoid Liposarcoma

Myxoid/Round Cell Liposarcoma	Liposarcoma, Myxoid
Mrcls	Myxoliposarcoma
MXLIPO	Liposarcoma Myxoid
Liposarcoma

Bone Sarcoma

Myxofibrosarcoma

Fibromyxosarcoma	Fibromyxoid Sarcoma
Myxoid Malignant Fibrous Histiocytoma	Dermatofibrosarcoma Protuberans, Myxoid

Holoprosencephaly

Holoprosencephaly Sequence	Hpe
Hpe - [Holoprosencephaly]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09552	NR4A3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	NR4A3	VGNC	VGNC:32247
Macaca mulatta	NR4A3	VGNC	VGNC:75519
Felis catus	NR4A3	VGNC	VGNC:68556
Rattus norvegicus	NR4A3	RGD	RGD:61882
Mus musculus	NR4A3	MGD	MGI:1352457

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