2. Gene
  3. CHRD - chordin Gene

CHRD - chordin Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens
Gene ID: 8646 | Gene type: protein coding

About CHRD

Cytogenetic location: 3q27.1 Genomic coordinates (GRCh38): 3:184,380,054-184,390,739 (from NCBI)

This gene has 17 transcripts (splice variants), 102 orthologues and 19 paralogues. Broad expression in endometrium (RPKM 10.5), liver (RPKM 6.4) and 23 other tissues.

Summary

This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]

CHRD Products(4)

mRNA Protein Name
NM_001304472.2 NP_001291401.1 chordin isoform 2 precursor
NM_001304473.2 NP_001291402.1 chordin isoform 3
NM_001304474.2 NP_001291403.1 chordin isoform 3
NM_003741.4 NP_003732.2 chordin isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19429706 GOA
Biological Process GO Annotation Evidence Reference Source
involved in BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
11472837 GOA
involved in negative regulation of BMP signaling pathway IMP
IMP: Inferred from mutant phenotype
11472837 GOA
involved in negative regulation of cell migration IDA
IDA: Inferred from direct assay
16449796 GOA
involved in negative regulation of osteoblast differentiation IMP
IMP: Inferred from mutant phenotype
18533030 GOA
involved in positive regulation of cell adhesion IDA
IDA: Inferred from direct assay
16449796 GOA
involved in positive regulation of mesenchymal cell proliferation IMP
IMP: Inferred from mutant phenotype
18533030 GOA
involved in spinal cord dorsal/ventral patterning IMP
IMP: Inferred from mutant phenotype
11472837 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CHRD Protein Structure

VWC

VWC: von Willebrand factor type C domain (51 - 125)

CHRD

CHRD: CHRD domain (172 - 272)

CHRD

CHRD: CHRD domain (281 - 397)

CHRD

CHRD: CHRD domain (406 - 519)

CHRD

CHRD: CHRD domain (533 - 646)

VWC

VWC: von Willebrand factor type C domain (705 - 762)

VWC

VWC: von Willebrand factor type C domain (792 - 850)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 955 a.a.
Protein Preferred Names Protein Names

chordin

CHRD Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
CHRD Q9H2X0 KRTAP10-8 Homo sapiens P60410
Validated Y2H
25416956
Intra
CHRD Q9H2X0 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP10-8 Homo sapiens P60410
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP10-8 Homo sapiens P60410
Y2H Prey Pooling
25416956
Intra
CHRD Q9H2X0 KRTAP10-9 Homo sapiens P60411
Y2H Array
25416956
Intra
CHRD Q9H2X0 KRTAP10-7 Homo sapiens P60409
Validated Y2H
25416956
Intra
CHRD Q9H2X0 KRTAP10-7 Homo sapiens P60409
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP10-7 Homo sapiens P60409
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP4-2 Homo sapiens Q9BYR5
Validated Y2H
25416956
Intra
CHRD Q9H2X0 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
25416956
Intra
CHRD Q9H2X0 KRTAP4-2 Homo sapiens Q9BYR5
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 ADAMTSL4 Homo sapiens Q6UY14-3
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP12-2 Homo sapiens P59991
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP12-2 Homo sapiens P59991
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP12-1 Homo sapiens P59990
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP12-1 Homo sapiens P59990
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP9-3 Homo sapiens Q9BYQ3
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRT34 Homo sapiens O76011
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRT34 Homo sapiens O76011
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP1-3 Homo sapiens Q8IUG1
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP12-3 Homo sapiens P60328
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP12-3 Homo sapiens P60328
Y2H Array
32296183
Intra
CHRD Q9H2X0 LCE5A Homo sapiens Q5TCM9
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 LCE5A Homo sapiens Q5TCM9
Y2H Array
32296183
Intra
CHRD Q9H2X0 LCE1F Homo sapiens Q5T754
Y2H Array
32296183
Intra
CHRD Q9H2X0 LCE1F Homo sapiens Q5T754
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP1-1 Homo sapiens Q07627
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP1-1 Homo sapiens Q07627
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP19-2 Homo sapiens Q3LHN2
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 LCE1C Homo sapiens Q5T751
Y2H Array
32296183
Intra
CHRD Q9H2X0 LCE1C Homo sapiens Q5T751
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 SPRY3 Homo sapiens O43610
Y2H Array
32296183
Intra
CHRD Q9H2X0 SPRY3 Homo sapiens O43610
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 CHRDL2 Homo sapiens Q6WN34-2
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 CHRDL2 Homo sapiens Q6WN34-2
Y2H Array
32296183
Intra
CHRD Q9H2X0 SLC15A2 Homo sapiens Q16348
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 SLC15A2 Homo sapiens Q16348
Y2H Array
32296183
Intra
CHRD Q9H2X0 NR4A3 Homo sapiens Q92570
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 NR4A3 Homo sapiens Q92570
Y2H Array
32296183
Intra
CHRD Q9H2X0 MEOX2 Homo sapiens Q6FHY5
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 MEOX2 Homo sapiens Q6FHY5
Y2H Array
32296183
Intra
CHRD Q9H2X0 POU4F2 Homo sapiens Q12837
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 POU4F2 Homo sapiens Q12837
Y2H Array
32296183
Intra
CHRD Q9H2X0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Array
32296183
Intra
CHRD Q9H2X0 NOTCH2NLC Homo sapiens P0DPK4
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP6-3 Homo sapiens Q3LI67
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP6-3 Homo sapiens Q3LI67
Y2H Array
32296183
Intra
CHRD Q9H2X0 LIN7A Homo sapiens O14910
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 LIN7A Homo sapiens O14910
Y2H Array
32296183
Intra
CHRD Q9H2X0 SMAD3 Homo sapiens P84022
Anti Tag CoIP
21988832
Intra
CHRD Q9H2X0 SMAD3 Homo sapiens P84022
Y2H
21988832
Intra
CHRD Q9H2X0 SPRY1 Homo sapiens O43609
Y2H Array
32296183
Intra
CHRD Q9H2X0 SPRY1 Homo sapiens O43609
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra
CHRD Q9H2X0 RGS17 Homo sapiens Q9UGC6
Validated Y2H
32296183
Intra
CHRD Q9H2X0 RGS17 Homo sapiens Q9UGC6
Y2H Array
32296183
Intra
CHRD Q9H2X0 RGS17 Homo sapiens Q9UGC6
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP5-9 Homo sapiens P26371
Validated Y2H
25416956
Intra
CHRD Q9H2X0 KRTAP5-9 Homo sapiens P26371
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP5-9 Homo sapiens P26371
Y2H Array
32296183
Intra
CHRD Q9H2X0 TRIM42 Homo sapiens Q8IWZ5
Y2H Array
32296183
Intra
CHRD Q9H2X0 TRIM42 Homo sapiens Q8IWZ5
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 INCA1 Homo sapiens Q0VD86
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 INCA1 Homo sapiens Q0VD86
Y2H Array
32296183
Intra
CHRD Q9H2X0 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 KRTAP4-12 Homo sapiens Q9BQ66
Y2H Array
32296183
Intra
CHRD Q9H2X0 PLSCR1 Homo sapiens O15162
Y2H Prey Pooling
25416956
Intra
CHRD Q9H2X0 OTX1 Homo sapiens P32242
Y2H Array
25416956
Intra
CHRD Q9H2X0 OTX1 Homo sapiens P32242
Validated Y2H
25416956
Intra
CHRD Q9H2X0 OTX1 Homo sapiens P32242
Y2H Prey Pooling
25416956
Intra
CHRD Q9H2X0 HOXA1 Homo sapiens P49639
Y2H Array
25416956
Intra
CHRD Q9H2X0 HOXA1 Homo sapiens P49639
Y2H Pooling
21653829
Intra
CHRD Q9H2X0 SPRY2 Homo sapiens O43597
Validated Y2H
25416956
Intra
CHRD Q9H2X0 CATSPER1 Homo sapiens Q8NEC5
Y2H Array
25416956
Intra
CHRD Q9H2X0 MEOX2 Homo sapiens P50222
Y2H Array
25416956
Intra
CHRD Q9H2X0 TSPAN4 Homo sapiens O14817
Y2H Array
32296183
Intra
CHRD Q9H2X0 TSPAN4 Homo sapiens O14817
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 GATA1 Homo sapiens P15976-2
Y2H Prey Pooling
32296183
Intra
CHRD Q9H2X0 GATA1 Homo sapiens P15976-2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Cornelia De Lange Syndrome

De Lange Syndrome

Brachmann De Lange Syndrome

Brachmann-De Lange Syndrome

Cdls

Bdls

Typus Degenerativus Amstelodamensis
Holoprosencephaly

Holoprosencephaly Sequence

Hpe

Hpe - [Holoprosencephaly]
Tarsal-Carpal Coalition Syndrome

TCC

Tarsal Carpal Coalition Syndrome

Nog-Related-Symphalangism Spectrum Disorder
Holoprosencephaly 4

HPE4

Holoprosencephaly-4

Holoprosencephaly, Type 4
Brachydactyly, Type B2

Brachydactyly Type B2

BDB2

Brachydactyly B2
Otospondylomegaepiphyseal Dysplasia, Autosomal Dominant

Weissenbacher-Zweymuller Syndrome

Wzs

Pierre Robin Syndrome With Fetal Chondrodysplasia

OSMEDA

Weissenbacher-Zweymüller Syndrome

Heterozygous Osmed

Stickler Syndrome, Type 3

Osmed, Heterozygous

Pierre Robin Syndrome With Fetal Chondrodysplasia Stickler Syndrome, Nonocular Type, Formerly

Stickler Syndrome, Type Iii, Formerly

Stl3, Formerly

Piere-Robin Syndrome

Pierre Robin Malformation

Heterozygous Otospondylomegaepiphyseal Dysplasia

Autosomal Dominant Otospondylomegaepiphyseal Dysplasia

Ad Osmed

Stickler Syndrome Type 3

Stickler Syndrome, Non-Ocular Type

Stickler-Like Syndrome

Stickler Syndrome 3

Stickler Syndrome Non-Ocular Type

Stickler Syndrome Type Iii

Stl3

Weissenbacher-Zweymueller Syndrome

Stickler Syndrome, Type Iii

Pierre Robin Syndrome

Dysplasia, Otospondylomegaepiphyseal, Autosomal Dominant
Sclerosteosis 1

SOST1

Sost

Cortical Hyperostosis With Syndactyly

Sclerosteosis

Sclerosteosis, Type 1
Proximal Symphalangism

Cushing'S Symphalangism

Symphalangism, Proximal

Hereditary Absence Of Proximal Interphalangeal Joints

Strasburger-Hawkins-Eldridge Syndrome

Strasburger-Hawkins-Eldridge-Hargrave-Mckusick Syndrome

Symphalangism, Proximal, 1a

Symphalangism, Proximal, 1b

Vessel'S Syndrome

Symphalangism, Cushing Type
Agnathia-Otocephaly Complex

Otocephaly

Holoprosencephaly-Agnathia

Dysgnathia Complex Agnathia-Holoprosencephaly

AGOTC

Agnathia-Holoprosencephaly-Situs Inversus Syndrome

Dysgnathia Complex

Agnathia-Holoprosencephaly

Cervical Auricle
Fibrodysplasia Ossificans Progressiva

Myositis Ossificans Progressiva

Progressive Myositis Ossificans

FOP

Progressive Ossifying Myositis

Myositis Ossificans

Stone Man Syndrome

Man Of Stone

Myositis Ossificans Progressive

Diffuse Progressive Ossifying Polymyositis

Fibrodysplasia Ossificans Congenita

Myositis Ossificans Progressiva, Site Unspecified

Münchmeyer Disease

Fop - [Fibrodysplasia Ossificans Progressiva]

Progressive Myositis Ossificans Calcification
Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos
Orofacial Cleft

Cleft, Orofacial
Congenital Nervous System Abnormality

Congenital Neurologic Anomaly

Congenital Nervous System Disorder
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS02656 CHRD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris CHRD VGNC VGNC:39228
Bos taurus CHRD VGNC VGNC:27316
Macaca mulatta CHRD VGNC VGNC:71042
Rattus norvegicus CHRD RGD RGD:620181
Mus musculus CHRD MGD MGI:1313268
Felis catus CHRD VGNC VGNC:60870
Others CHRD NCBI