ULBP2 - UL16 binding protein 2 Gene

Homo sapiens

Also known as N2DL2; RAET1H; RAET1L; NKG2DL2; ALCAN-alpha

Gene ID: 80328 | Gene type: protein coding

About ULBP2

Cytogenetic location: 6q25.1 Genomic coordinates (GRCh38): 6:149,942,014-149,949,235 (from NCBI)

This gene has 1 transcript (splice variant), 302 orthologues and 22 paralogues. Biased expression in esophagus (RPKM 5.0), lung (RPKM 1.3) and 11 other tissues.

Summary

This gene encodes a major histocompatibility complex (MHC) class I-related molecule that binds to the NKG2D receptor on natural killer (NK) cells to trigger release of multiple cytokines and chemokines that in turn contribute to the recruitment and activation of NK cells. The encoded protein undergoes further processing to generate the mature protein that is either anchored to membrane via a glycosylphosphatidylinositol moiety, or secreted. Many malignant cells secrete the encoded protein to evade immunosurveillance by NK cells. This gene is located in a cluster of multiple MHC class I-related genes on chromosome 6. [provided by RefSeq, Jul 2015]

ULBP2 Products(1)

mRNA	Protein	Name
NM_025217.4	NP_079493.1	UL16-binding protein 2 preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables natural killer cell lectin-like receptor binding	IDA IDA: Inferred from direct assay	11239445	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19424970	GOA
enables receptor ligand activity	IDA IDA: Inferred from direct assay	11777960	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in natural killer cell activation	IDA IDA: Inferred from direct assay	11239445	GOA
involved in natural killer cell mediated cytotoxicity	IDA IDA: Inferred from direct assay	11239445	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell surface	IDA IDA: Inferred from direct assay	18676862	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	18676862	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11239445	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ULBP2 Protein Structure

MHC_I

0
100
200
246 a.a.

Protein Preferred Names

Protein Names

UL16-binding protein 2

NKG2D ligand 2

ULBP2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ULBP2	Q9BZM5	KLRK1	Homo sapiens	P26718	FACS	19424970

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant ULBP2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71164	NKG2DL2 Protein, Human (HEK293, His)	Q9BZM5 (G26-S217)	≥95%
HY-P78226	NKG2DL2 Protein, Human (Biotinylated, HEK293, His-Avi)	Q9BZM5 (G26-S217)	≥95%
HY-P78534	NKG2DL2 Protein, Human (HEK293, His-Avi)	Q9BZM5 (G26-S217)	≥95%
HY-P701055	ULBP2/NKG2DL2 Protein, Human (HEK293, hFc)	Q9BZM5 (G26-S216)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15449	ULBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	ULBP2	MGD	MGI:1925027

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