KCNIP4 - potassium voltage-gated channel interacting protein 4 Gene

Homo sapiens

Also known as CALP; KCHIP4

Gene ID: 80333 | Gene type: protein coding

About KCNIP4

Cytogenetic location: 4p15.31-p15.2 Genomic coordinates (GRCh38): 4:20,728,606-21,948,772 (from NCBI)

This gene has 10 transcripts (splice variants), 1 gene allele, 221 orthologues and 14 paralogues. Broad expression in brain (RPKM 3.7), endometrium (RPKM 1.2) and 15 other tissues.

Summary

This gene encodes a member of the family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the recoverin branch of the EF-hand superfamily. Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. This protein member also interacts with presenilin. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

KCNIP4 Products(7)

mRNA	Protein	Name
NM_001035003.2	NP_001030175.1	Kv channel-interacting protein 4 isoform 5
NM_001035004.2	NP_001030176.1	Kv channel-interacting protein 4 isoform 3
NM_001363504.2	NP_001350433.1	Kv channel-interacting protein 4 isoform 6
NM_025221.6	NP_079497.2	Kv channel-interacting protein 4 isoform 1
NM_147181.4	NP_671710.1	Kv channel-interacting protein 4 isoform 2
NM_147182.4	NP_671711.1	Kv channel-interacting protein 4 isoform 3
NM_147183.3	NP_671712.1	Kv channel-interacting protein 4 isoform 4

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	11847232	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	26871637	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11847232	GOA
located in peroxisome	IDA IDA: Inferred from direct assay	22057399	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11847232	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KCNIP4 Protein Structure

EF-hand_8

EF-hand_7

0
100
200
250 a.a.

Protein Preferred Names

Protein Names

Kv channel-interacting protein 4

Kv channel interacting protein 4

KCNIP4 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	KCNIP4	Q6PIL6	IL17A	Homo sapiens	Q16552	Y2H Prey Pooling	32296183
Intra	KCNIP4	Q6PIL6	IL17A	Homo sapiens	Q16552	Y2H Array	32296183
Intra	KCNIP4	Q6PIL6	ASPH	Homo sapiens	Q12797-6	Y2H Array	32296183
Intra	KCNIP4	Q6PIL6	ASPH	Homo sapiens	Q12797-6	Y2H Prey Pooling	32296183
Intra	KCNIP4	Q6PIL6	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
Intra	KCNIP4	Q6PIL6	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
Intra	KCNIP4	Q6PIL6	GOLGA7	Homo sapiens	Q7Z5G4	Validated Y2H	32296183
Intra	KCNIP4	Q6PIL6	GOLGA7	Homo sapiens	Q7Z5G4	Y2H Array	32296183
Intra	KCNIP4	Q6PIL6	GOLGA7	Homo sapiens	Q7Z5G4	Y2H Prey Pooling	32296183
Intra	KCNIP4	Q6PIL6	LITAF	Homo sapiens	Q99732	Validated Y2H	32296183
Intra	KCNIP4	Q6PIL6	COL1A2	Homo sapiens	P08123	Y2H Prey Pooling	32296183
Intra	KCNIP4	Q6PIL6	COL1A2	Homo sapiens	P08123	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Synovial Angioma

Hemangioma Of Synovium

Synovial Hemangioma

Esophageal Adenoid Cystic Carcinoma

Adenoid Cystic Carcinoma, Esophagus

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07135	KCNIP4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	KCNIP4	VGNC	VGNC:63043
Canis familiaris	KCNIP4	VGNC	VGNC:42257
Macaca mulatta	KCNIP4	VGNC	VGNC:73950
Mus musculus	KCNIP4	MGD	MGI:1933131
Rattus norvegicus	KCNIP4	RGD	RGD:708539
Bos taurus	KCNIP4	VGNC	VGNC:30452

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