GOLGA7 - golgin A7 Gene

Homo sapiens

Also known as GCP16; GOLGA7A; HSPC041; GOLGA3AP1

Gene ID: 51125 | Gene type: protein coding

About GOLGA7

Cytogenetic location: 8p11.21 Genomic coordinates (GRCh38): 8:41,490,396-41,510,980 (from NCBI)

This gene has 34 transcripts (splice variants), 289 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 33.3), testis (RPKM 26.7) and 25 other tissues.

Summary

Involved in Golgi to plasma membrane protein transport; peptidyl-L-cysteine S-palmitoylation; and protein stabilization. Acts upstream of or within Golgi to plasma membrane transport. Located in Golgi membrane and Golgi stack. Is intrinsic component of Golgi membrane. Part of palmitoyltransferase complex. [provided by Alliance of Genome Resources, Apr 2022]

GOLGA7 Products(5)

mRNA	Protein	Name
NM_001002296.2	NP_001002296.1	golgin subfamily A member 7 isoform a
NM_001174124.2	NP_001167595.1	golgin subfamily A member 7 isoform b
NM_001362979.1	NP_001349908.1	golgin subfamily A member 7 isoform a
NM_001362980.2	NP_001349909.1	golgin subfamily A member 7 isoform a
NM_016099.3	NP_057183.2	golgin subfamily A member 7 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	14522980	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in Golgi to plasma membrane protein transport	IDA IDA: Inferred from direct assay	14522980	GOA
acts upstream of or within Golgi to plasma membrane transport	IDA IDA: Inferred from direct assay	14522980	GOA
involved in peptidyl-L-cysteine S-palmitoylation	IDA IDA: Inferred from direct assay	16000296	GOA
involved in protein stabilization	IDA IDA: Inferred from direct assay	16000296	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in Golgi membrane	IDA IDA: Inferred from direct assay	14522980	GOA
located in Golgi stack	IDA IDA: Inferred from direct assay	14522980	GOA
part of palmitoyltransferase complex	IDA IDA: Inferred from direct assay	16000296	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GOLGA7 Protein Structure

Erf4

0
100
137 a.a.

Protein Preferred Names

Protein Names

golgin subfamily A member 7

Golgi complex-associated protein of 16kDa

GOLGA7 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	GOLGA7	Q7Z5G4	MID2	Homo sapiens	Q9UJV3-2	Validated Y2H	32296183
Intra	GOLGA7	Q7Z5G4	MID2	Homo sapiens	Q9UJV3-2	Y2H Prey Pooling	32296183
Intra	GOLGA7	Q7Z5G4	MID2	Homo sapiens	Q9UJV3-2	Y2H Array	32296183
Intra	GOLGA7	Q7Z5G4	KCNIP2	Homo sapiens	Q9NS61-2	Validated Y2H	32296183
Cross	GOLGA7	Q7Z5G4	S	SARS-CoV-2	P0DTC2	Anti Tag CoIP	34117209
Cross	GOLGA7	Q7Z5G4	S	SARS-CoV-2	P0DTC2	Confocal	35115020
Intra	GOLGA7	Q7Z5G4	FGFR3	Homo sapiens	P22607	Y2H Pooling	32814053
Intra	GOLGA7	Q7Z5G4	FGFR3	Homo sapiens	P22607	Validated Y2H	32814053
Intra	GOLGA7	Q7Z5G4	FGFR3	Homo sapiens	P22607	Y2H Array	32814053
Intra	GOLGA7	Q7Z5G4	MESD	Homo sapiens	Q14696	Y2H Array	32296183
Intra	GOLGA7	Q7Z5G4	MESD	Homo sapiens	Q14696	Y2H Prey Pooling	32296183
Intra	GOLGA7	Q7Z5G4	KCNIP3	Homo sapiens	Q9Y2W7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05588	GOLGA7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS05589	GOLGA7B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	GOLGA7	MGD	MGI:1931029
Canis familiaris	GOLGA7	VGNC	VGNC:41342
Bos taurus	GOLGA7	VGNC	VGNC:29487
Rattus norvegicus	GOLGA7	RGD	RGD:1359725
Macaca mulatta	GOLGA7	VGNC	VGNC:73002

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