2. Gene
  3. Sost - sclerostin Gene

Sost - sclerostin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 80722 | Gene type: protein coding

About Sost

Summary

Predicted to enable BMP binding activity. Involved in ossification. Located in Golgi apparatus and extracellular space. Part of protein-containing complex. Human ortholog(s) of this gene implicated in SOST-related sclerosing bone dysplasia; autosomal dominant craniodiaphyseal dysplasia; sclerosteosis; and sclerosteosis 1. Orthologous to human SOST (sclerostin). [provided by Alliance of Genome Resources, Apr 2022]

Sost Products(1)

mRNA Protein Name
NM_030584.2 NP_085073.1 sclerostin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
15199066 RGD
Biological Process GO Annotation Evidence Reference Source
involved in ossification IEP
IEP: Inferred from expression pattern
15199066 RGD
Cellular Component GO Annotation Evidence Reference Source
located in Golgi apparatus IDA
IDA: Inferred from direct assay
17696759 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
15199066 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15199066 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

sclerostin

sclerosteosis

Recombinant Sost Proteins

Cat. No. Product Name Accession Purity
HY-P71623 SOST Protein, Rat (Myc, His) Q99P67 (29F-213Y) ≥95%

Related Agents

Clinical Phase
Inhibitory Antibodies (2)
Cat. No. Product Name Effect
Purity Phase
HY-P99186 Blosozumab / Phase 2
HY-P990696 Resugosbart / Phase 1
Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13578 SOST Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Sost NCBI NCBI:50964
Macaca fascicularis Sost NCBI NCBI:102130808
Mus musculus Sost NCBI NCBI:74499