SPX - spexin hormone Gene

Homo sapiens

Also known as C12orf39

Gene ID: 80763 | Gene type: protein coding

About SPX

Cytogenetic location: 12p12.1 Genomic coordinates (GRCh38): 12:21,526,296-21,532,947 (from NCBI)

This gene has 8 transcripts (splice variants) and 180 orthologues. Biased expression in fat (RPKM 72.3), thyroid (RPKM 9.5) and 4 other tissues.

Summary

The protein encoded by this gene is a hormone involved in modulation of cardiovascular and renal function. It has also been shown in rats to cause weight loss. Several transcript variants have been found for this gene. [provided by RefSeq, Feb 2016]

SPX Products(1)

mRNA	Protein	Name
NM_030572.4	NP_085049.1	spexin precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neuropeptide hormone activity	IDA IDA: Inferred from direct assay	24517231	GOA
enables neuropeptide hormone activity	IMP IMP: Inferred from mutant phenotype	17284679	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables type 2 galanin receptor binding	IDA IDA: Inferred from direct assay	24517231	GOA
enables type 3 galanin receptor binding	IDA IDA: Inferred from direct assay	24517231	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of gastro-intestinal system smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	17284679	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	24517231	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in dense core granule	IDA IDA: Inferred from direct assay	17284679	GOA
located in extracellular space	IDA IDA: Inferred from direct assay	17284679	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPX Protein Structure

Spexin

0
100
116 a.a.

Protein Preferred Names

Protein Names

spexin

NPQ

SPX Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SPX	Q9BT56	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	SPX	Q9BT56	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Noonan Syndrome 9

NS9	Noonan Syndrome, Type 9

Acute Endophthalmitis

Bjornstad Syndrome

BJS	Pili Torti And Nerve Deafness
Ptd	Pili Torti-Deafness Syndrome
Deafness-Pili Torti-Hypogonadism Syndrome	Deafness And Pili Torti, Bjornstad Type
Pili Torti-Sensorineural Hearing Loss	Björnstad Syndrome
Ptnd	Hearing Loss-Pili Torti-Hypogonadism Syndrome
Bjoernstad Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P5931	Spinoxin	Inhibitor	≥98.0%	Phase 1

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13741	SPX Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SPX	VGNC	VGNC:100108
Canis familiaris	SPX	VGNC	VGNC:46784
Mus musculus	SPX	MGD	MGI:2442262
Felis catus	SPX	VGNC	VGNC:65667
Rattus norvegicus	SPX	RGD	RGD:1587448
Bos taurus	SPX	VGNC	VGNC:35262

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