2. Gene
  3. USP5 - ubiquitin specific peptidase 5 Gene

USP5 - ubiquitin specific peptidase 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as ISOT

Gene ID: 8078 | Gene type: protein coding

About USP5

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,852,150-6,866,632 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 36.2), brain (RPKM 33.4) and 25 other tissues.

Summary

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]

USP5 Products(6)

mRNA Protein Name
NM_001098536.2 NP_001092006.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 1
NM_001382588.1 NP_001369517.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 3
NM_001382589.1 NP_001369518.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 4
NM_001382590.1 NP_001369519.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 5
NM_001382591.1 NP_001369520.1 ubiquitin carboxyl-terminal hydrolase 5 isoform 6
NM_003481.3 NP_003472.2 ubiquitin carboxyl-terminal hydrolase 5 isoform 2

USP5 Protein Structure

zf-UBP

zf-UBP: Zn-finger in ubiquitin-hydrolases and other protein (199 - 271)

UCH

UCH: Ubiquitin carboxyl-terminal hydrolase (325 - 853)

UBA

UBA: UBA/TS-N domain (656 - 691)

UBA

UBA: UBA/TS-N domain (725 - 759)

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  • 858 a.a.
Protein Preferred Names Protein Names

ubiquitin carboxyl-terminal hydrolase 5

deubiquitinating enzyme 5

Recombinant USP5 Proteins

Cat. No. Product Name Accession Purity
HY-P74479 USP5 Protein, Human (sf9, His) P45974-2 (M1-S835) ≥95%

Related Diseases

Diseases Alias
Non-Syndromic X-Linked Intellectual Disability 99

Mrx99

X-Linked Mental Retardation 99
Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia

Adca

Pierre Marie Cerebellar Ataxia

Ataxia, Spinocerebellar

Sca

Autosomal Dominant Spinocerebellar Ataxia

Spinocerebellar Ataxias
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-13814 PR-619 99.38% Unkown
HY-13264 Degrasyn 99.70% Unkown
HY-139979 USP5-IN-1 Inhibitor 99.80% Unkown
HY-111408 EOAI3402143 Inhibitor 98.95% Unkown
HY-122243 IU1-47 Inhibitor 99.68% Unkown
HY-103435 Vialinin A Inhibitor 99.89% Unkown
HY-134817 USP7-IN-8 Inhibitor 99.04% Unkown
HY-RS15561 USP5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta USP5 VGNC VGNC:78747
Canis familiaris USP5 VGNC VGNC:48201
Felis catus USP5 VGNC VGNC:66893
Mus musculus USP5 MGD MGI:1347343
Bos taurus USP5 VGNC VGNC:36735
Rattus norvegicus USP5 RGD RGD:1308438
Others USP5 NCBI