USP5 - ubiquitin specific peptidase 5 Gene

Homo sapiens

Also known as ISOT

Gene ID: 8078 | Gene type: protein coding

About USP5

Cytogenetic location: 12p13.31 Genomic coordinates (GRCh38): 12:6,852,150-6,866,632 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues and 71 paralogues. Ubiquitous expression in testis (RPKM 36.2), brain (RPKM 33.4) and 25 other tissues.

Summary

Ubiquitin (see MIM 191339)-dependent proteolysis is a complex pathway of protein metabolism implicated in such diverse cellular functions as maintenance of chromatin structure, receptor function, and degradation of abnormal proteins. A late step of the process involves disassembly of the polyubiquitin chains on degraded proteins into ubiquitin monomers. USP5 disassembles branched polyubiquitin chains by a sequential exo mechanism, starting at the proximal end of the chain (Wilkinson et al., 1995 [PubMed 7578059]).[supplied by OMIM, Mar 2010]

USP5 Products(6)

mRNA	Protein	Name
NM_001098536.2	NP_001092006.1	ubiquitin carboxyl-terminal hydrolase 5 isoform 1
NM_001382588.1	NP_001369517.1	ubiquitin carboxyl-terminal hydrolase 5 isoform 3
NM_001382589.1	NP_001369518.1	ubiquitin carboxyl-terminal hydrolase 5 isoform 4
NM_001382590.1	NP_001369519.1	ubiquitin carboxyl-terminal hydrolase 5 isoform 5
NM_001382591.1	NP_001369520.1	ubiquitin carboxyl-terminal hydrolase 5 isoform 6
NM_003481.3	NP_003472.2	ubiquitin carboxyl-terminal hydrolase 5 isoform 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	EXP EXP: Inferred from Experiment	26235645	GOA
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	24424410	GOA
enables deubiquitinase activity	IDA IDA: Inferred from direct assay	26917723	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA
enables ubiquitin binding	IDA IDA: Inferred from direct assay	24424410	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of ubiquitin-dependent protein catabolic process	IDA IDA: Inferred from direct assay	24424410	GOA
involved in positive regulation of proteasomal ubiquitin-dependent protein catabolic process	IMP IMP: Inferred from mutant phenotype	19098288	GOA
involved in protein K48-linked deubiquitination	IMP IMP: Inferred from mutant phenotype	19098288	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP5 Protein Structure

zf-UBP

UCH

UBA

0
200
400
600
800
858 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 5

deubiquitinating enzyme 5

USP5 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP5	P45974	DAZAP2	Homo sapiens	Q15038	Y2H Prey Pooling	25416956
Intra	USP5	P45974	TMEM239	Homo sapiens	Q8WW34	Validated Y2H	25416956
Intra	USP5	P45974	TMEM239	Homo sapiens	Q8WW34	Y2H Prey Pooling	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant USP5 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P74479	USP5 Protein, Human (sf9, His)	P45974-2 (M1-S835)	≥95%

Related Diseases

Diseases

Alias

Non-Syndromic X-Linked Intellectual Disability 99

Mrx99

X-Linked Mental Retardation 99

Autosomal Dominant Cerebellar Ataxia

Spinocerebellar Ataxia	Adca
Pierre Marie Cerebellar Ataxia	Ataxia, Spinocerebellar
Sca	Autosomal Dominant Spinocerebellar Ataxia
Spinocerebellar Ataxias

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (8)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-13814	PR-619		99.38%	Unkown
HY-13264	Degrasyn		99.70%	Unkown
HY-139979	USP5-IN-1	Inhibitor	99.80%	Unkown
HY-111408	EOAI3402143	Inhibitor	98.95%	Unkown
HY-122243	IU1-47	Inhibitor	99.68%	Unkown
HY-103435	Vialinin A	Inhibitor	99.89%	Unkown
HY-134817	USP7-IN-8	Inhibitor	99.04%	Unkown
HY-RS15561	USP5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	USP5	VGNC	VGNC:78747
Canis familiaris	USP5	VGNC	VGNC:48201
Felis catus	USP5	VGNC	VGNC:66893
Mus musculus	USP5	MGD	MGI:1347343
Bos taurus	USP5	VGNC	VGNC:36735
Rattus norvegicus	USP5	RGD	RGD:1308438
Others	USP5	NCBI

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