Vialinin A (Synonyms: Terrestrin A)

Name: Vialinin A
Brand: MedChemExpress
SKU: HY-103435
Rating: 5.0 (2 reviews)

Cat. No.: HY-103435 Purity: 99.90%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A (Terrestrin A) can be used for autoimmune diseases and cancer research.

For research use only. We do not sell to patients.

Vialinin A Chemical Structure

CAS No. : 858134-23-3

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 2 publication(s) in Google Scholar

2 Publications Citing Use of MCE Vialinin A

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties^[1]. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A (Terrestrin A) can be used for autoimmune diseases and cancer research^[2]^[3].

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	IC₅₀	7 μM Compound: Vialinin A	Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs	[PMID: 35901638]
Mast cell	IC₅₀	0.04 nM Compound: Vialinin A	Inhibition of TNF-alpha production in mouse bone marrow-derived mast cells measured after 15 mins by ELISA Inhibition of TNF-alpha production in mouse bone marrow-derived mast cells measured after 15 mins by ELISA	[PMID: 27491710]
RBL-2H3	IC₅₀	0.09 nM Compound: Vialinin A	Inhibition of TNF-alpha production in antigen-stimulated rat RBL2H3 cells measured after 15 mins by ELISA Inhibition of TNF-alpha production in antigen-stimulated rat RBL2H3 cells measured after 15 mins by ELISA	[PMID: 27491710]
RBL-2H3	IC₅₀	0.09 nM Compound: 1	Inhibition of TNF-alpha production in rat RBL2H3 cells after 16 hrs by ELISA Inhibition of TNF-alpha production in rat RBL2H3 cells after 16 hrs by ELISA	[PMID: 23791076]
RBL-2H3	IC₅₀	0.09 nM Compound: 2	Inhibition of DNP-BSA-stimulated TNF-alpha production in rat RBL2H3 cells preincubated for 15 mins followed by DNP-BSA addition measured after 3 hrs by ELISA Inhibition of DNP-BSA-stimulated TNF-alpha production in rat RBL2H3 cells preincubated for 15 mins followed by DNP-BSA addition measured after 3 hrs by ELISA	[PMID: 24679673]
RBL-2H3	IC₅₀	90 pM Compound: 1	Antiinflammatory activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced TNF-alpha production preincubated for 15 mins prior DNP-BSA challenge measured after 30 mins by ELISA Antiinflammatory activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced TNF-alpha production preincubated for 15 mins prior DNP-BSA challenge measured after 30 mins by ELISA	[PMID: 22410084]

Molecular Weight

562.57

Formula

C₃₄H₂₆O₈

CAS No.

858134-23-3

Appearance

Solid

Color

White to light brown

SMILES

O=C(CC1=CC=CC=C1)OC2=C(C(C3=CC=C(C=C3)O)=C(C(O)=C2C4=CC=C(O)C=C4)O)OC(CC5=CC=CC=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (177.76 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7776 mL	8.8878 mL	17.7756 mL
5 mM	0.3555 mL	1.7776 mL	3.5551 mL
10 mM	0.1778 mL	0.8888 mL	1.7776 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (4.44 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.90%

Select Batch:

Data Sheet (277 KB) SDS (252 KB)

COA (254 KB) HNMR (268 KB) LCMS (99 KB)

Handling Instructions (2659 KB)

References

[1]. Ji-Kai Liu, et al. Natural terphenyls: developments since 1877. Chem Rev. 2006 Jun;106(6):2209-23. [Content Brief]

[2]. Jie Xu, et al. Ubiquitously specific protease 4 inhibitor-Vialinin A attenuates inflammation and fibrosis in S100-induced hepatitis mice through Rheb/mTOR signalling.J Cell Mol Med. 2021 Jan;25(2):1140-1150. [Content Brief]

[3]. Himangshu Sonowal,et al. Vialinin A, an Edible Mushroom-Derived p-Terphenyl Antioxidant, Prevents VEGF-Induced Neovascularization In Vitro and In Vivo. Oxid Med Cell Longev. 2018 Feb 6;2018:1052102. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7776 mL	8.8878 mL	17.7756 mL	44.4389 mL
	5 mM	0.3555 mL	1.7776 mL	3.5551 mL	8.8878 mL
	10 mM	0.1778 mL	0.8888 mL	1.7776 mL	4.4439 mL
	15 mM	0.1185 mL	0.5925 mL	1.1850 mL	2.9626 mL
	20 mM	0.0889 mL	0.4444 mL	0.8888 mL	2.2219 mL
	25 mM	0.0711 mL	0.3555 mL	0.7110 mL	1.7776 mL
	30 mM	0.0593 mL	0.2963 mL	0.5925 mL	1.4813 mL
	40 mM	0.0444 mL	0.2222 mL	0.4444 mL	1.1110 mL
	50 mM	0.0356 mL	0.1778 mL	0.3555 mL	0.8888 mL
	60 mM	0.0296 mL	0.1481 mL	0.2963 mL	0.7406 mL
	80 mM	0.0222 mL	0.1111 mL	0.2222 mL	0.5555 mL
	100 mM	0.0178 mL	0.0889 mL	0.1778 mL	0.4444 mL

Vialinin A Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Vialinin A858134-23-3Terrestrin ADeubiquitinaseDUBsAntioxidantUSP4USP5autoimmune diseaseinflammationfibrosisInhibitorinhibitorinhibit

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Vialinin A (Synonyms: Terrestrin A)

Customer Review

Vialinin A Related Antibodies

2 Publications Citing Use of MCE Vialinin A

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

View All Deubiquitinase Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Vialinin A Related Classifications

Keywords:

Your Recently Viewed Products:

Customer Review

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SAFETY DATA SHEET (SDS)

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