1. Cell Cycle/DNA Damage
  2. Deubiquitinase
  3. Vialinin A

Vialinin A  (Synonyms: Terrestrin A)

Cat. No.: HY-103435 Purity: 99.89%
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Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A (Terrestrin A) can be used for autoimmune diseases and cancer research.

For research use only. We do not sell to patients.

Vialinin A Chemical Structure

Vialinin A Chemical Structure

CAS No. : 858134-23-3

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Customer Review

Based on 2 publication(s) in Google Scholar

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Description

Vialinin A (Terrestrin A) is a p-terphenyl compound with antioxidant properties[1]. Vialinin A is a potent inhibitor of TNF-α, USP4, USP5, and sentrin/SUMO-specific protease 1 (SENP1). Vialinin A (Terrestrin A) can be used for autoimmune diseases and cancer research[2][3].

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
7 μM
Compound: Vialinin A
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs
Antiproliferative activity against human HepG2 cells assessed as cell growth inhibition measured after 48 hrs
[PMID: 35901638]
Mast cell IC50
0.04 nM
Compound: Vialinin A
Inhibition of TNF-alpha production in mouse bone marrow-derived mast cells measured after 15 mins by ELISA
Inhibition of TNF-alpha production in mouse bone marrow-derived mast cells measured after 15 mins by ELISA
[PMID: 27491710]
RBL-2H3 IC50
0.09 nM
Compound: Vialinin A
Inhibition of TNF-alpha production in antigen-stimulated rat RBL2H3 cells measured after 15 mins by ELISA
Inhibition of TNF-alpha production in antigen-stimulated rat RBL2H3 cells measured after 15 mins by ELISA
[PMID: 27491710]
RBL-2H3 IC50
0.09 nM
Compound: 1
Inhibition of TNF-alpha production in rat RBL2H3 cells after 16 hrs by ELISA
Inhibition of TNF-alpha production in rat RBL2H3 cells after 16 hrs by ELISA
[PMID: 23791076]
RBL-2H3 IC50
0.09 nM
Compound: 2
Inhibition of DNP-BSA-stimulated TNF-alpha production in rat RBL2H3 cells preincubated for 15 mins followed by DNP-BSA addition measured after 3 hrs by ELISA
Inhibition of DNP-BSA-stimulated TNF-alpha production in rat RBL2H3 cells preincubated for 15 mins followed by DNP-BSA addition measured after 3 hrs by ELISA
[PMID: 24679673]
RBL-2H3 IC50
90 pM
Compound: 1
Antiinflammatory activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced TNF-alpha production preincubated for 15 mins prior DNP-BSA challenge measured after 30 mins by ELISA
Antiinflammatory activity in rat RBL2H3 cells assessed as inhibition of DNP-BSA-induced TNF-alpha production preincubated for 15 mins prior DNP-BSA challenge measured after 30 mins by ELISA
[PMID: 22410084]
Molecular Weight

562.57

Formula

C34H26O8

CAS No.
Appearance

Solid

Color

White to light brown

SMILES

O=C(CC1=CC=CC=C1)OC2=C(C(C3=CC=C(C=C3)O)=C(C(O)=C2C4=CC=C(O)C=C4)O)OC(CC5=CC=CC=C5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (35.55 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7776 mL 8.8878 mL 17.7756 mL
5 mM 0.3555 mL 1.7776 mL 3.5551 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.89%

References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7776 mL 8.8878 mL 17.7756 mL 44.4389 mL
5 mM 0.3555 mL 1.7776 mL 3.5551 mL 8.8878 mL
10 mM 0.1778 mL 0.8888 mL 1.7776 mL 4.4439 mL
15 mM 0.1185 mL 0.5925 mL 1.1850 mL 2.9626 mL
20 mM 0.0889 mL 0.4444 mL 0.8888 mL 2.2219 mL
25 mM 0.0711 mL 0.3555 mL 0.7110 mL 1.7776 mL
30 mM 0.0593 mL 0.2963 mL 0.5925 mL 1.4813 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Vialinin A
Cat. No.:
HY-103435
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