TMX1 - thioredoxin related transmembrane protein 1 Gene

Homo sapiens

Also known as TMX; TXNDC; PDIA11; TXNDC1

Gene ID: 81542 | Gene type: protein coding

About TMX1

Cytogenetic location: 14q22.1 Genomic coordinates (GRCh38): 14:51,240,247-51,257,655 (from NCBI)

This gene has 3 transcripts (splice variants), 226 orthologues and 13 paralogues. Ubiquitous expression in urinary bladder (RPKM 15.6), colon (RPKM 14.8) and 25 other tissues.

Summary

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and one transmembrane domain. Unlike most members of this gene family, it lacks a C-terminal ER-retention sequence. The mature membrane-bound protein can both oxidize and reduce disulfide bonds and acts selectively on membrane-associated polypeptides. [provided by RefSeq, Jan 2017]

TMX1 Products(1)

mRNA	Protein	Name
NM_030755.5	NP_110382.3	thioredoxin-related transmembrane protein 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables disulfide oxidoreductase activity	IDA IDA: Inferred from direct assay	11152479	GOA
enables enzyme inhibitor activity	IDA IDA: Inferred from direct assay	37648867	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA
enables protein disulfide isomerase activity	IDA IDA: Inferred from direct assay	29932915	GOA
enables protein-disulfide reductase activity	IDA IDA: Inferred from direct assay	22228764	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of platelet aggregation	IDA IDA: Inferred from direct assay	30425049	GOA
involved in negative regulation of triglyceride biosynthetic process	IDA IDA: Inferred from direct assay	37648867	GOA
involved in positive regulation of ERAD pathway	IDA IDA: Inferred from direct assay	29932915	GOA
involved in regulation of calcium ion transport	IDA IDA: Inferred from direct assay	27502484	GOA
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	11152479	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	37648867	GOA
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	11152479	GOA
is active in mitochondria-associated endoplasmic reticulum membrane contact site	IDA IDA: Inferred from direct assay	22045338	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMX1 Protein Structure

Thioredoxin

0
100
200
280 a.a.

Protein Preferred Names

Protein Names

thioredoxin-related transmembrane protein 1

protein disulfide isomerase family A, member 11

Recombinant TMX1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76681	TMX1 Protein, Human (HEK293, Fc)	AAH36460 (R27-S180)	≥95%

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153385	TMX1	Degrader	99.09%	Unkown
HY-RS14779	TMX1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	TMX1	VGNC	VGNC:47643
Mus musculus	TMX1	MGD	MGI:1919986
Rattus norvegicus	TMX1	RGD	RGD:1308455
Macaca mulatta	TMX1	VGNC	VGNC:103880
Bos taurus	TMX1	VGNC	VGNC:50016
Others	TMX1	NCBI

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