2. Gene
  3. Alox15 - arachidonate 15-lipoxygenase Gene

Alox15 - arachidonate 15-lipoxygenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as 12-LOX; 15-LOX; Alox12; Alox12l

Gene ID: 81639 | Gene type: protein coding

About Alox15

Primary_assembly 10: 55,060,412-55,068,874 reverse strand.mRatBN7.2:CM026983.1

This gene has 2 transcripts (splice variants), 168 orthologues, 6 paralogues and is associated with 22 phenotypes. Biased expression in Spleen (RPKM 287.1), Lung (RPKM 941.1) and 1 other tissue.

Summary

Enables hepoxilin A3 synthase activity; hepoxilin-epoxide hydrolase activity; and oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen. Involved in fatty acid metabolic process and positive regulation of heterotypic cell-cell adhesion. Located in cytosol. Biomarker of brain ischemia; congestive heart failure; and glomerulonephritis. Orthologous to human ALOX15 (arachidonate 15-lipoxygenase). [provided by Alliance of Genome Resources, Apr 2022]

Alox15 Products(1)

mRNA Protein Name
NM_031010.2 NP_112272.2 polyunsaturated fatty acid lipoxygenase ALOX15
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables arachidonate 12(S)-lipoxygenase activity IDA
IDA: Inferred from direct assay
8117750 RGD
enables arachidonate 15-lipoxygenase activity IDA
IDA: Inferred from direct assay
8444196 RGD
enables hepoxilin A3 synthase activity IDA
IDA: Inferred from direct assay
15123652 RGD
enables hepoxilin-epoxide hydrolase activity IDA
IDA: Inferred from direct assay
15123652 RGD
Biological Process GO Annotation Evidence Reference Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
8117750 RGD
involved in hepoxilin biosynthetic process IDA
IDA: Inferred from direct assay
15123652 RGD
involved in lipoxygenase pathway IDA
IDA: Inferred from direct assay
8117750 RGD
involved in positive regulation of heterotypic cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
15576842 RGD
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
15123652 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Alox15 Protein Structure

PLAT

PLAT: cl00011 (137 - 204)

Lipoxygenase

Lipoxygenase: cl37981 (294 - 746)

  • 0
  • 200
  • 400
  • 600
  • 756 a.a.
Protein Preferred Names Protein Names

polyunsaturated fatty acid lipoxygenase ALOX15

12/15-LOX

12/15-lipoxygenase

arachidonate 12-lipoxygenase, leukocyte-type

arachidonate omega-6 lipoxygenase

hepoxilin A3 synthase Alox15

linoleate 13S-lipoxygenase

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-143787 ALOX15-IN-1 Inhibitor 98.09% Unkown
HY-143791 ALOX15-IN-2 Inhibitor 99.88% Unkown
HY-RS00616 ALOX15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00617 Alox15 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00618 Alox15 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00619 ALOX15B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Alox15 NCBI NCBI:246