2. Gene
  3. ALOX15 - arachidonate 15-lipoxygenase Gene

ALOX15 - arachidonate 15-lipoxygenase Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LOG15; 12-LOX; 15-LOX; 15-LOX-1

Gene ID: 246 | Gene type: protein coding

About ALOX15

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,630,919-4,641,678 (from NCBI)

This gene has 6 transcripts (splice variants), 168 orthologues and 5 paralogues. Biased expression in lung (RPKM 5.0), small intestine (RPKM 1.7) and 11 other tissues.

Summary

This gene encodes a member of the Lipoxygenase family of proteins. The encoded Enzyme acts on various polyunsaturated fatty acid substrates to generate various bioactive lipid mediators such as eicosanoids, hepoxilins, lipoxins, and Other molecules. The encoded Enzyme and its reaction products have been shown to regulate inflammation and immunity. Multiple pseudogenes of this gene have been identified in the human genome. [provided by RefSeq, Aug 2017]

ALOX15 Products(1)

mRNA Protein Name
NM_001140.5 NP_001131.3 polyunsaturated fatty acid lipoxygenase ALOX15
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables arachidonate 12(S)-lipoxygenase activity IDA
IDA: Inferred from direct assay
1944593 GOA
enables arachidonate 15-lipoxygenase activity IDA
IDA: Inferred from direct assay
1944593 GOA
enables linoleate 13S-lipoxygenase activity IDA
IDA: Inferred from direct assay
8334154 GOA
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: Inferred from direct assay
17052953 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21831839 GOA
Biological Process GO Annotation Evidence Reference Source
involved in arachidonate metabolic process IDA
IDA: Inferred from direct assay
1944593 GOA
involved in cellular response to calcium ion IDA
IDA: Inferred from direct assay
17052953 GOA
involved in cellular response to interleukin-13 IMP
IMP: Inferred from mutant phenotype
21831839 GOA
involved in linoleic acid metabolic process IDA
IDA: Inferred from direct assay
8334154 GOA
involved in lipid metabolic process IDA
IDA: Inferred from direct assay
23242647 GOA
involved in lipoxygenase pathway IDA
IDA: Inferred from direct assay
1944593 GOA
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: Inferred from mutant phenotype
21831839 GOA
involved in positive regulation of cell-substrate adhesion IDA
IDA: Inferred from direct assay
11278875 GOA
involved in regulation of inflammatory response IDA
IDA: Inferred from direct assay
23242647 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
17052953 GOA
located in cytosol IDA
IDA: Inferred from direct assay
17052953 GOA
located in lipid droplet IDA
IDA: Inferred from direct assay
19528634 GOA
located in membrane IDA
IDA: Inferred from direct assay
21831839 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALOX15 Protein Structure

PLAT

PLAT: PLAT/LH2 domain (4 - 104)

Lipoxygenase

Lipoxygenase: Lipoxygenase (157 - 210)

Lipoxygenase

Lipoxygenase: Lipoxygenase (211 - 654)

  • 0
  • 200
  • 400
  • 600
  • 662 a.a.
Protein Preferred Names Protein Names

polyunsaturated fatty acid lipoxygenase ALOX15

12/15-lipoxygenase

15-LOX type 1

15-lipooxygenase-1

15-lipoxygenase type 1

arachidonate 12-lipoxygenase, leukocyte-type

arachidonate omega-6 lipoxygenase

hepoxilin A3 synthase Alox15

linoleate 13S-lipoxygenase

ALOX15 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
ALOX15 P16050 TIMM29 Homo sapiens Q9BSF4
Anti Tag CoIP
28514442
Intra
ALOX15 P16050 TIMM29 Homo sapiens Q9BSF4
Anti Tag CoIP
33961781
Cross: Cross-species interaction Intra: Intraspecies interaction

ALOX15 Antibodies

Cat. No. Product Name Application Reactivity
HY-P81346 15 Lipoxygenase 1 Antibody (YA1091) IHC-P Human
HY-P81564 ALOX15 Antibody (YA1309) IHC-P, ICC/IF, FC Human

Related Diseases

Diseases Alias
Ichthyosis, Congenital, Autosomal Recessive 3

Autosomal Recessive Congenital Ichthyosis 3

ARCI3

Lamellar Ichthyosis 5

Collodion Baby, Self-Healing

Ichthyosis, Lamellar, 5, Formerly

Li5, Formerly

Li5

Self-Healing Collodion Baby

Ichthyosis, Congenital, Autosomal Recessive, Type 3
Malaria

Malaria, Susceptibility To

Malaria, Resistance To

Malaria, Cerebral

Cerebral Malaria

Malaria, Severe, Susceptibility To

Malaria, Severe, Resistance To

Malaria, Cerebral, Susceptibility To

Induced Malaria

Malaria, Vivax, Protection Against

Malaria, Severe

Malaria, Cerebral, Reduced Risk Of

Malaria, Protection Against

Resistance To Malaria Due To G6pd Deficiency

Malaria Due To G6pd Deficiency

Malarial Encephalitis

CM

Malaria Cerebral

Susceptibility To Malaria

Acute Pernicious Fever

Aestivo-Autumnal Fever

Aestivo Autumnal Malaria

Chagres Fever

Continued Malaria Fever

Estivo-Autumnal Fever

Estivo-Autumnal Malaria

Estivo-Autumnal Malarial Fever

Falciparum Fever

Malignant Tertian Fever

Malignant Tertian Malaria

Pernicious Intermittent Fever

Pernicious Malaria

Quotidian Malaria

Subtertian Fever

Subtertian Malaria Fever

Subtertian Malignant Tertian Malaria

Tropical Malaria

Algid Malaria

Bilious Haemoglobinuric Fever

Black Water Fever

Blackwater Fever

Malarial Blackwater Fever

Severe Malarial Falciparum

West African Fever

Malarial Haematinuria

Haemoglobinuric Fever

Haemoglobinuric Malaria

Severe Plasmodium Falciparum Malaria

Malarial Haemoglobinuria

Malarial Haematuria

Falciparum Malaria [Malignant Tertian]

Malaria Tropica

Malarial Shock

Chagres Virus Disease

Malignant Malaria

Mtm - [Malignant Tertian Malaria]

Tm -[Malignant Tertian Malaria]

Panama Fever

St - [Subtertian Malaria]

Malarial Quotidian

Benign Tertian Malaria

Tertian Ague

Vivax Fever

Plasmodium Vivax Malaria Nos

Btm - [Benign Tertian Malaria]

Bt - [Benign Tertian Malaria]

Vivax Malaria

Benign Tertian Vivax Malaria

Tertian Malaria

Quartan Malaria

Quartan Ague

Quartan Fever

Plasmodium Malariae Malaria Nos

Quartan Malarial

Malaria By Plasmodium Malariae

Malariae Malaria

Ovale Tertian Malaria

Plasmodium Ovale Fever

Malaria Fever By Plasmodium Ovale

Ovale Malaria

Malaria By Plasmodium Ovale

Malarial Ovale

Marsh Fever

Remittent Congestive Fever

Coastal Fever

Remittent Gastric Fever

Miasmatic Fever

Congestive Remittent Fever

Intermittent Fever

Jungle Fever

Paludism

Cameroon Fever

Ague

Corsican Fever

Intermittent Bilious Fever

Disease Due To Plasmodiidae

Malarial Fever

Plasmodiosis

Remittent Fever

Roman Fever

Malaria Fever Nos

Malaria Nos

Paludal Fever

Clinically Diagnosed Malaria

Clinically Diagnosed Malaria Without Parasitological Confirmation

Congestive Fever

Malarial Cachexia

Marsh Cachexia

Paludal Cachexia

Recurrent Malaria

Remittent Malaria
Cone-Rod Dystrophy 17

CORD17
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (6)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-143791 ALOX15-IN-2 Inhibitor 99.88% Unkown
HY-143787 ALOX15-IN-1 Inhibitor 98.09% Unkown
HY-RS00616 ALOX15 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00617 Alox15 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00618 Alox15 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS00619 ALOX15B Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ALOX15 VGNC VGNC:25843
Mus musculus ALOX15 MGD MGI:87997
Rattus norvegicus ALOX15 RGD RGD:70493
Macaca mulatta ALOX15 VGNC VGNC:69796
Canis familiaris ALOX15 VGNC VGNC:37811
Others ALOX15 NCBI