1. Gene
  2. CCNL2 - cyclin L2 Gene

CCNL2 - cyclin L2 Gene

Homo sapiens

Also known as CCNM; CCNS; PCEE; SB138; ANIA-6B; HLA-ISO; HCLA-ISO

Gene ID: 81669 | Gene type: protein coding

About CCNL2

Cytogenetic location: 1p36.33 Genomic coordinates (GRCh38): 1:1,385,711-1,399,335 (from NCBI)

This gene has 19 transcripts (splice variants), 145 orthologues and 6 paralogues. Ubiquitous expression in skin (RPKM 45.3), endometrium (RPKM 44.2) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the cyclin family. Through its interaction with several proteins, such as RNA polymerase II, splicing factors, and cyclin-dependent kinases, this protein functions as a regulator of the pre-mRNA splicing process, as well as in inducing Apoptosis by modulating the expression of apoptotic and antiapoptotic proteins. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011]

CCNL2 Products(8)

mRNA Protein Name
NM_001039577.5 NP_001034666.1 cyclin-L2 isoform B
NM_001320153.3 NP_001307082.1 cyclin-L2 isoform C
NM_001320155.3 NP_001307084.1 cyclin-L2 isoform C
NM_001350497.1 NP_001337426.1 cyclin-L2 isoform C
NM_001350498.2 NP_001337427.1 cyclin-L2 isoform C
NM_001350499.2 NP_001337428.1 cyclin-L2 isoform D
NM_001350500.2 NP_001337429.1 cyclin-L2 isoform D
NM_030937.6 NP_112199.2 cyclin-L2 isoform A
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
25416956 GOA
Biological Process GO Annotation Evidence Reference Source
involved in regulation of RNA splicing IDA
IDA: Inferred from direct assay
18216018 GOA
Cellular Component GO Annotation Evidence Reference Source
part of cyclin-dependent protein kinase holoenzyme complex IPI
IPI: Inferred from physical interaction
18216018 GOA
located in nucleus IDA
IDA: Inferred from direct assay
17494991 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CCNL2 Protein Structure

Cyclin_N

Cyclin_N: Cyclin, N-terminal domain (72 - 191)

Cyclin_C

Cyclin_C: Cyclin, C-terminal domain (215 - 288)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

cyclin-L2

cyclin M

Related Diseases

Diseases Alias
Toe Syndactyly, Telecanthus, And Anogenital And Renal Malformations

Star Syndrome

Syndactyly-Telecanthus-Anogenital And Renal Malformations Syndrome

Syndactyly With Renal And Anogenital Malformations

STAR

Syndactyly, Telecanthus, Anogenital And Renal Malformations

Toe Syndactyly, Telecanthus, Anogenital And Renal Malformations

Jalili Syndrome

Cone-Rod Dystrophy And Amelogenesis Imperfecta

Cone Rod Dystrophy-Amelogenesis Imperfecta Syndrome

Cone-Rod Dystrophy Amelogenesis Imperfecta

Cone-Rod Dystrophy With Amelogenesis Imperfecta

JALIS

Cone Rod Dystrophy Amelogenesis Imperfecta

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

Townes-Brocks Syndrome

Townes Syndrome

Renal-Ear-Anal-Radial Syndrome

Anus, Imperforate, With Hand, Foot And Ear Anomalies

Imperforate Anus-Hand, Foot And Ear Anomalies Syndrome

Rear Syndrome

Sensorineural Deafness With Imperforate Anus And Hypoplastic Thumbs

Tbs

Deafness, Sensorineural, With Imperforate Anus And Hypoplastic Thumbs

Imperforate Anus With Hand, Foot And Ear Anomalies

Anal-Ear-Renal-Radial Malformation Syndrome

Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

Imperforate Anus-Hand And Foot Anomalies Syndrome

Sensorineural Deafness-Imperforate Anus-Hypoplastic Thumbs Syndrome

Sensorineural Hearing Loss With Imperforate Anus And Hypoplastic Thumbs

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Felis catus CCNL2 VGNC VGNC:80161
Canis familiaris CCNL2 VGNC VGNC:38905
Bos taurus CCNL2 VGNC VGNC:26976
Rattus norvegicus CCNL2 RGD RGD:1309149
Mus musculus CCNL2 MGD MGI:1927119