SLC14A2 - solute carrier family 14 member 2 Gene

Homo sapiens

Also known as UT2; UTA; UTR; HUT2; UT-A2; hUT-A6

Gene ID: 8170 | Gene type: protein coding

About SLC14A2

Cytogenetic location: 18q12.3 Genomic coordinates (GRCh38): 18:45,167,963-45,683,688 (from NCBI)

This gene has 3 transcripts (splice variants), 251 orthologues and 1 paralogue. Biased expression in kidney (RPKM 2.6), fat (RPKM 1.3) and 7 other tissues.

Summary

The protein encoded by this gene belongs to the Urea Transporter family. In mammalian cells, urea is the chief end product of nitrogen catabolism, and plays an important role in the urinary concentration mechanism. This protein is expressed in the inner medulla of the kidney, and mediates rapid transepithelial urea transport across the inner medullary collecting duct. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2011]

SLC14A2 Products(3)

mRNA	Protein	Name
NM_001242692.2	NP_001229621.1	urea transporter 2
NM_001371319.1	NP_001358248.1	urea transporter 2
NM_007163.4	NP_009094.3	urea transporter 2

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cell adhesion molecule binding	IDA IDA: Inferred from direct assay	23620790	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	17702749	GOA
enables urea transmembrane transporter activity	IDA IDA: Inferred from direct assay	8647271	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	17702749	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	17702749	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC14A2 Protein Structure

0
200
400
600
800
920 a.a.

Protein Preferred Names

Protein Names

urea transporter 2

solute carrier family 14 (urea transporter), member 2

SLC14A2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLC14A2	Q15849	C4orf3	Homo sapiens	Q8WVX3-2	Validated Y2H	32296183
Intra	SLC14A2	Q15849	TMEM97	Homo sapiens	Q5BJF2	Complementation	32296183
Intra	SLC14A2	Q15849	TMEM97	Homo sapiens	Q5BJF2	Validated Y2H	32296183
Intra	SLC14A2	Q15849	CMTM7	Homo sapiens	Q96FZ5	Validated Y2H	32296183
Intra	SLC14A2	Q15849	LRP10	Homo sapiens	Q7Z4F1	Validated Y2H	32296183
Intra	SLC14A2	Q15849	LAT	Homo sapiens	O43561-2	Y2H Array	32296183
Intra	SLC14A2	Q15849	SEC22A	Homo sapiens	Q96IW7	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Bone Chondrosarcoma

Yaws

Frambesia	Frambesia Tropica
Bouba	Frambosie
Polypapilloma Tropicum	Thymosis
Endemic Treponematoses	Treponema Pertenue Infection
Pian	Framboesia
Framboesia Tropica	Castellani
Infection By Treponema Pertenue	Parangi
Framboesioma	Chancre Of Yaws
Primary Framboesia	Initial Lesions Of Yaws
Mother Yaw	Initial Framboesia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13011	SLC14A2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	SLC14A2	VGNC	VGNC:77392
Mus musculus	SLC14A2	MGD	MGI:1351653
Bos taurus	SLC14A2	VGNC	VGNC:34678
Canis familiaris	SLC14A2	VGNC	VGNC:49648
Rattus norvegicus	SLC14A2	RGD	RGD:3689

Name
Email *

	Sorry, but the email address you supplied was invalid.