2. Gene
  3. TMEM97 - transmembrane protein 97 Gene

TMEM97 - transmembrane protein 97 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as MAC30; sigma2R

Gene ID: 27346 | Gene type: protein coding

About TMEM97

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,319,200-28,328,685 (from NCBI)

This gene has 5 transcripts (splice variants) and 195 orthologues. Broad expression in testis (RPKM 51.1), liver (RPKM 43.9) and 23 other tissues.

Summary

TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular Cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]

TMEM97 Products(1)

mRNA Protein Name
NM_014573.3 NP_055388.2 sigma intracellular receptor 2
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
19583955 GOA
Biological Process GO Annotation Evidence Reference Source
involved in cholesterol homeostasis IDA
IDA: Inferred from direct assay
19583955 GOA
involved in positive regulation of lipoprotein transport IMP
IMP: Inferred from mutant phenotype
30443021 GOA
involved in positive regulation of wound healing IMP
IMP: Inferred from mutant phenotype
34233061 GOA
involved in regulation of intracellular cholesterol transport IMP
IMP: Inferred from mutant phenotype
27378690 GOA
involved in regulation of intracellular lipid transport IMP
IMP: Inferred from mutant phenotype
27378690 GOA
Cellular Component GO Annotation Evidence Reference Source
is active in endoplasmic reticulum IDA
IDA: Inferred from direct assay
34233061 GOA
located in lysosome IDA
IDA: Inferred from direct assay
19583955 GOA
located in nuclear membrane IDA
IDA: Inferred from direct assay
19583955 GOA
located in plasma membrane IDA
IDA: Inferred from direct assay
19583955 GOA
located in rough endoplasmic reticulum IDA
IDA: Inferred from direct assay
19583955 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM97 Protein Structure

DUF2781

DUF2781: Protein of unknown function (DUF2781) (11 - 165)

  • 0
  • 100
  • 176 a.a.
Protein Preferred Names Protein Names

sigma intracellular receptor 2

meningioma-associated protein 30

sigma-2 receptor

sigma2 receptor

TMEM97 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
TMEM97 Q5BJF2 SGPL1 Homo sapiens O95470
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 SGPL1 Homo sapiens O95470
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 NEMP1 Homo sapiens O14524-2
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 NEMP1 Homo sapiens O14524-2
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 CLSTN3 Homo sapiens Q9BQT9
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 CLSTN3 Homo sapiens Q9BQT9
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 CLSTN3 Homo sapiens Q9BQT9
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 ARL13B Homo sapiens Q3SXY8
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 ARL13B Homo sapiens Q3SXY8
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 GPX8 Homo sapiens Q8TED1
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 GPX8 Homo sapiens Q8TED1
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 MFF Homo sapiens Q9GZY8-5
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 MFF Homo sapiens Q9GZY8-5
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 MFF Homo sapiens Q9GZY8-5
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 RNF170 Homo sapiens Q96K19-5
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 RNF170 Homo sapiens Q96K19-5
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 RNF170 Homo sapiens Q96K19-5
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 SPINT1 Homo sapiens O43278-2
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 SPINT1 Homo sapiens O43278-2
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 FXYD3 Homo sapiens Q14802-3
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 FXYD3 Homo sapiens Q14802-3
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 PLP1 Homo sapiens P60201-2
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 PLP1 Homo sapiens P60201-2
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 CD74 Homo sapiens P04233-2
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 CD74 Homo sapiens P04233-2
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 ASZ1 Homo sapiens Q8WWH4
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 ASZ1 Homo sapiens Q8WWH4
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 ASZ1 Homo sapiens Q8WWH4
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 AQP2 Homo sapiens P41181
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 AQP2 Homo sapiens P41181
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 AQP6 Homo sapiens Q13520
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 AQP6 Homo sapiens Q13520
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 GPR152 Homo sapiens Q8TDT2
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 GPR152 Homo sapiens Q8TDT2
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 GPR152 Homo sapiens Q8TDT2
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 SLC14A2 Homo sapiens Q15849
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 SLC14A2 Homo sapiens Q15849
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 RHCG Homo sapiens Q9UBD6
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 RHCG Homo sapiens Q9UBD6
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 RHCG Homo sapiens Q9UBD6
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 PDCD1LG2 Homo sapiens Q9BQ51
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 PDCD1LG2 Homo sapiens Q9BQ51
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 REEP1 Homo sapiens Q9H902
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 REEP1 Homo sapiens Q9H902
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 REEP1 Homo sapiens Q9H902
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 MUC1 Homo sapiens P15941-11
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 MUC1 Homo sapiens P15941-11
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 AQP12B Homo sapiens A6NM10-2
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 AQP12B Homo sapiens A6NM10-2
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 SSMEM1 Homo sapiens Q8WWF3
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 SSMEM1 Homo sapiens Q8WWF3
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 SSMEM1 Homo sapiens Q8WWF3
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 LEUTX Homo sapiens A8MZ59
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 LEUTX Homo sapiens A8MZ59
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 CPLX4 Homo sapiens Q7Z7G2
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 CPLX4 Homo sapiens Q7Z7G2
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 CPLX4 Homo sapiens Q7Z7G2
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 HSD17B13 Homo sapiens Q7Z5P4
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 HSD17B13 Homo sapiens Q7Z5P4
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 HSD17B13 Homo sapiens Q7Z5P4
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 TMEM52B Homo sapiens Q4KMG9
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 TMEM52B Homo sapiens Q4KMG9
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 FAM209A Homo sapiens Q5JX71
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 FAM209A Homo sapiens Q5JX71
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 FAM209A Homo sapiens Q5JX71
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 SLC14A1 Homo sapiens Q13336-2
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 SLC14A1 Homo sapiens Q13336-2
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 CGRRF1 Homo sapiens Q99675
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 CGRRF1 Homo sapiens Q99675
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 CGRRF1 Homo sapiens Q99675
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 ATP6AP2 Homo sapiens O75787
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 ATP6AP2 Homo sapiens O75787
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 NDUFAF2 Homo sapiens Q8N183
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 NDUFAF2 Homo sapiens Q8N183
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 NDUFAF2 Homo sapiens Q8N183
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 LHFPL5 Homo sapiens Q8TAF8
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 LHFPL5 Homo sapiens Q8TAF8
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 LHFPL5 Homo sapiens Q8TAF8
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 TMEM106C Homo sapiens Q9BVX2
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 TMEM106C Homo sapiens Q9BVX2
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 TMEM106C Homo sapiens Q9BVX2
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 LIME1 Homo sapiens Q9H400
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 LIME1 Homo sapiens Q9H400
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 LIME1 Homo sapiens Q9H400
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 FFAR2 Homo sapiens O15552
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 FFAR2 Homo sapiens O15552
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 GPR37L1 Homo sapiens O60883
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 GPR37L1 Homo sapiens O60883
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 LRRC59 Homo sapiens Q96AG4
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 LRRC59 Homo sapiens Q96AG4
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 IFNGR2 Homo sapiens P38484
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 IFNGR2 Homo sapiens P38484
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 GJB3 Homo sapiens O75712
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 GJB3 Homo sapiens O75712
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 GJB5 Homo sapiens O95377
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 GJB5 Homo sapiens O95377
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 EBP Homo sapiens Q15125
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 EBP Homo sapiens Q15125
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 FKBP7 Homo sapiens Q9Y680
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 FKBP7 Homo sapiens Q9Y680
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 FKBP7 Homo sapiens Q9Y680
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 SAR1A Homo sapiens Q9NR31
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 SAR1A Homo sapiens Q9NR31
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 SAR1A Homo sapiens Q9NR31
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 TMEM45B Homo sapiens Q96B21
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 TMEM45B Homo sapiens Q96B21
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 TMEM45B Homo sapiens Q96B21
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 MTIF3 Homo sapiens Q9H2K0
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 MTIF3 Homo sapiens Q9H2K0
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 MTIF3 Homo sapiens Q9H2K0
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 MRM1 Homo sapiens Q6IN84
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 MRM1 Homo sapiens Q6IN84
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 MRM1 Homo sapiens Q6IN84
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 TMX2 Homo sapiens Q9Y320
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 TMX2 Homo sapiens Q9Y320
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 TMX2 Homo sapiens Q9Y320
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 CD53 Homo sapiens P19397
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 CD53 Homo sapiens P19397
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 FRMD3 Homo sapiens A2A2Y4
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 FRMD3 Homo sapiens A2A2Y4
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 BIK Homo sapiens Q13323
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 BIK Homo sapiens Q13323
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 PDZK1IP1 Homo sapiens Q13113
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 PDZK1IP1 Homo sapiens Q13113
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 CLDN7 Homo sapiens O95471
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 CLDN7 Homo sapiens O95471
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 NDUFAF1 Homo sapiens Q9Y375
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 NDUFAF1 Homo sapiens Q9Y375
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 NDUFAF1 Homo sapiens Q9Y375
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 VSIR Homo sapiens Q9H7M9
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 VSIR Homo sapiens Q9H7M9
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 VSIR Homo sapiens Q9H7M9
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 BCL2L13 Homo sapiens Q9BXK5
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 BCL2L13 Homo sapiens Q9BXK5
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 BCL2L13 Homo sapiens Q9BXK5
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 ERGIC3 Homo sapiens Q9Y282
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 ERGIC3 Homo sapiens Q9Y282
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 ERGIC3 Homo sapiens Q9Y282
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 KIR2DL3 Homo sapiens P43628
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 KIR2DL3 Homo sapiens P43628
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 TMEM14B Homo sapiens Q9NUH8
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 TMEM14B Homo sapiens Q9NUH8
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 TMEM14B Homo sapiens Q9NUH8
Y2H Array
32296183
Intra
TMEM97 Q5BJF2 TMEM79 Homo sapiens Q9BSE2
Y2H Prey Pooling
32296183
Intra
TMEM97 Q5BJF2 TMEM79 Homo sapiens Q9BSE2
Validated Y2H
32296183
Intra
TMEM97 Q5BJF2 TMEM79 Homo sapiens Q9BSE2
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Meningioma, Familial

Meningioma

Familial Meningioma

Meningioma, Familial, Susceptibility To

Meningeal Neoplasm

Meningeal Neoplasms

Meningiomas

Meningioma, Nf2-Related, Somatic

Meningioma, Sis-Related

Meningothelial Cell Tumor

Neoplasm Of The Meninges

Primary Meningeal Tumor

Familial Multiple Meningioma

MNGMA

Meningioma, Benign, No Icd-O Subtype

Intracranial Meningioma

Meningothelial Cell Neoplasm

Supratentorial Meningioma

Primary Neoplasm Of Spinal Meninges

Benign Intracranial Meningioma

Benign Meningioma

Meningeal Tumours

Meningeal Sarcoma Of Unspecified Site

Meningothelial Sarcoma Of Unspecified Site
Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C

NPC1

Niemann-Pick Disease, Type D

Niemann-Pick Disease Type C1

Niemann-Pick Disease With Cholesterol Esterification Block

Niemann-Pick Disease, Subacute Juvenile Form

Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia

Npc

Niemann-Pick Disease, Chronic Neuronopathic Form

Niemann-Pick Disease Without Sphingomyelinase Deficiency

Niemann-Pick Disease Type C

Niemann-Pick Disease Type D

Niemann-Pick C1 Disease

Niemann-Pick Disease C1

Niemann-Pick Disease Chronic Neuronopathic Form

Niemann-Pick Disease Nova Scotian Type

Niemann-Pick Disease Subacute Juvenile Form

Niemann-Pick Disease Type Ii

Niemann-Picks Disease Type C
Combined Oxidative Phosphorylation Deficiency 37

COXPD37
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14750 TMEM97 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14751 Tmem97 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS14752 Tmem97 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus TMEM97 RGD RGD:1307423
Mus musculus TMEM97 MGD MGI:1916321
Macaca mulatta TMEM97 VGNC VGNC:79683
Bos taurus TMEM97 VGNC VGNC:36129
Canis familiaris TMEM97 VGNC VGNC:47617
Felis catus TMEM97 VGNC VGNC:97664
Others TMEM97 NCBI