TMEM97 - transmembrane protein 97 Gene

Homo sapiens

Also known as MAC30; sigma2R

Gene ID: 27346 | Gene type: protein coding

About TMEM97

Cytogenetic location: 17q11.2 Genomic coordinates (GRCh38): 17:28,319,200-28,328,685 (from NCBI)

This gene has 5 transcripts (splice variants) and 195 orthologues. Broad expression in testis (RPKM 51.1), liver (RPKM 43.9) and 23 other tissues.

Summary

TMEM97 is a conserved integral membrane protein that plays a role in controlling cellular Cholesterol levels (Bartz et al., 2009 [PubMed 19583955]).[supplied by OMIM, Aug 2009]

TMEM97 Products(1)

mRNA	Protein	Name
NM_014573.3	NP_055388.2	sigma intracellular receptor 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19583955	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	19583955	GOA
involved in positive regulation of lipoprotein transport	IMP IMP: Inferred from mutant phenotype	30443021	GOA
involved in positive regulation of wound healing	IMP IMP: Inferred from mutant phenotype	34233061	GOA
involved in regulation of intracellular cholesterol transport	IMP IMP: Inferred from mutant phenotype	27378690	GOA
involved in regulation of intracellular lipid transport	IMP IMP: Inferred from mutant phenotype	27378690	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
is active in endoplasmic reticulum	IDA IDA: Inferred from direct assay	34233061	GOA
located in lysosome	IDA IDA: Inferred from direct assay	19583955	GOA
located in nuclear membrane	IDA IDA: Inferred from direct assay	19583955	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	19583955	GOA
located in rough endoplasmic reticulum	IDA IDA: Inferred from direct assay	19583955	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TMEM97 Protein Structure

DUF2781

0
100
176 a.a.

Protein Preferred Names

Protein Names

sigma intracellular receptor 2

meningioma-associated protein 30	sigma-2 receptor
sigma2 receptor

Related Diseases

Diseases

Alias

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Niemann-Pick Disease, Type C1

Niemann-Pick Disease, Type C	NPC1
Niemann-Pick Disease, Type D	Niemann-Pick Disease Type C1
Niemann-Pick Disease With Cholesterol Esterification Block	Niemann-Pick Disease, Subacute Juvenile Form
Neurovisceral Storage Disease With Vertical Supranuclear Ophthalmoplegia	Npc
Niemann-Pick Disease, Chronic Neuronopathic Form	Niemann-Pick Disease Without Sphingomyelinase Deficiency
Niemann-Pick Disease Type C	Niemann-Pick Disease Type D
Niemann-Pick C1 Disease	Niemann-Pick Disease C1
Niemann-Pick Disease Chronic Neuronopathic Form	Niemann-Pick Disease Nova Scotian Type
Niemann-Pick Disease Subacute Juvenile Form	Niemann-Pick Disease Type Ii
Niemann-Picks Disease Type C

Combined Oxidative Phosphorylation Deficiency 37

COXPD37

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14750	TMEM97 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14751	Tmem97 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14752	Tmem97 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TMEM97	RGD	RGD:1307423
Mus musculus	TMEM97	MGD	MGI:1916321
Macaca mulatta	TMEM97	VGNC	VGNC:79683
Bos taurus	TMEM97	VGNC	VGNC:36129
Canis familiaris	TMEM97	VGNC	VGNC:47617
Felis catus	TMEM97	VGNC	VGNC:97664
Others	TMEM97	NCBI

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