P2rx3 - purinergic receptor P2X 3 Gene

Rattus norvegicus

Gene ID: 81739 | Gene type: protein coding

About P2rx3

Primary_assembly 3: 70,080,851-70,125,178 reverse strand.mRatBN7.2:CM026976.1

This gene has 2 transcripts (splice variants), 275 orthologues, 6 paralogues and is associated with 2 phenotypes. Biased expression in Kidney (RPKM 11.6), Adrenal (RPKM 5.2) and 9 other tissues.

Summary

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and identical protein binding activity. Involved in several processes, including behavioral response to formalin induced pain; neuronal action potential; and positive regulation of sensory perception of pain. Located in several cellular components, including dendritic spine; membrane raft; and rough endoplasmic reticulum. Is integral component of plasma membrane. Is integral component of presynaptic membrane. Orthologous to human P2RX3 (purinergic receptor P2X 3). [provided by Alliance of Genome Resources, Apr 2022]

P2rx3 Products(2)

mRNA	Protein	Name
NM_001270621.1	NP_001257550.1	P2X purinoceptor 3 isoform 2
NM_031075.2	NP_112337.2	P2X purinoceptor 3 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	12581826	RGD
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: Inferred from direct assay	7566119	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	15313628	RGD
enables purinergic nucleotide receptor activity	IDA IDA: Inferred from direct assay	7566119	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to formalin induced pain	IMP IMP: Inferred from mutant phenotype	24120766	RGD
involved in cellular response to ATP	IDA IDA: Inferred from direct assay	7566119	RGD
involved in neuronal action potential	IDA IDA: Inferred from direct assay	12581826	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	9721930	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	9721930	RGD
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	7566119	RGD
is active in presynaptic membrane	IDA IDA: Inferred from direct assay	26801076	RGD
located in terminal bouton	IDA IDA: Inferred from direct assay	9721930	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

P2rx3 Protein Structure

P2X_receptor

0
100
200
300
416 a.a.

Protein Preferred Names

Protein Names

P2X purinoceptor 3

ATP receptor	P2X3
purinergic receptor P2X, ligand-gated ion channel, 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS09903	P2RX3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09904	P2rx3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09905	P2rx3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	P2rx3	NCBI	NCBI:5024

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