NUAK2 - NUAK family kinase 2 Gene

Homo sapiens

Also known as ANPH2; SNARK

Gene ID: 81788 | Gene type: protein coding

About NUAK2

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:205,302,063-205,321,745 (from NCBI)

This gene has 1 transcript (splice variant), 213 orthologues, 17 paralogues and is associated with 1 phenotype. Broad expression in esophagus (RPKM 10.7), kidney (RPKM 9.5) and 22 other tissues.

Summary

Enables ATP binding activity; magnesium ion binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cellular response to glucose starvation; negative regulation of apoptotic process; and protein phosphorylation. Predicted to be active in cytoplasm. Implicated in anencephaly. [provided by Alliance of Genome Resources, Apr 2022]

NUAK2 Products(3)

mRNA	Protein	Name
XM_005245515.5	XP_005245572.1	NUAK family SNF1-like kinase 2 isoform X2
XM_047431309.1	XP_047287265.1	NUAK family SNF1-like kinase 2 isoform X1
NM_030952.3	NP_112214.3	NUAK family SNF1-like kinase 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATP binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	14976552	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	19927127	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	14976552	GOA
enables protein serine/threonine kinase activity	IMP IMP: Inferred from mutant phenotype	32845958	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in actin cytoskeleton organization	IDA IDA: Inferred from direct assay	14575707	GOA
involved in cellular response to glucose starvation	IDA IDA: Inferred from direct assay	14575707	GOA
involved in negative regulation of apoptotic process	IDA IDA: Inferred from direct assay	15345718	GOA
involved in protein localization to nucleus	IMP IMP: Inferred from mutant phenotype	32845958	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	14976552	GOA
involved in regulation of hippo signaling	IMP IMP: Inferred from mutant phenotype	32845958	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUAK2 Protein Structure

Pkinase

0
100
200
300
400
500
628 a.a.

Protein Preferred Names

Protein Names

NUAK family SNF1-like kinase 2

NUAK family, SNF1-like kinase, 2	SNF1/AMP activated protein kinase
SNF1/AMP kinase-related kinase	omphalocele kinase 2

NUAK2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	NUAK2	Q9H093	SFN	Homo sapiens	P31947	Pull Down	32707033
Intra	NUAK2	Q9H093	GRIPAP1	Homo sapiens	Q4V328	Y2H Prey Pooling	32296183
Intra	NUAK2	Q9H093	GRIPAP1	Homo sapiens	Q4V328	Y2H Array	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Anencephaly 2

ANPH2

Omphalocele

Omphalocoele	Congenital Omphalocele
Exomphalos	Exumbilication

Anencephaly

Aprosencephaly	Anencephalus
Congenital Absence Of Brain	Absence Of A Large Part Of The Brain And The Skull
Anencephalia	Anencephalic Monster
Brain Absence	Brain Agenesis
Brain Aplasia	Absent Brain
Anencephalic	Congenital Absence Of Cerebrum
Congenital Hemicrania	Incomplete Anencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15802	WZ4003	Inhibitor	98.03%	Unkown
HY-120877	MRT199665	Inhibitor	99.74%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	NUAK2	RGD	RGD:1359167
Canis familiaris	NUAK2	VGNC	VGNC:53124
Mus musculus	NUAK2	MGD	MGI:1921387
Felis catus	NUAK2	VGNC	VGNC:107907
Macaca mulatta	NUAK2	VGNC	VGNC:75484

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