CAPNS1 - calpain small subunit 1 Gene

Homo sapiens

Also known as CANP; CDPS; CSS1; CANPS; CAPN4; CALPAIN4

Gene ID: 826 | Gene type: protein coding

About CAPNS1

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:36,140,066-36,150,353 (from NCBI)

This gene has 17 transcripts (splice variants), 296 orthologues and 20 paralogues. Ubiquitous expression in esophagus (RPKM 128.4), heart (RPKM 97.8) and 25 other tissues.

Summary

This gene is a member of the calpain small subunit family. Calpains are calcium-dependent cysteine proteinases that are widely distributed in mammalian cells. Calpains operate as heterodimers, comprising a specific large catalytic subunit (calpain 1 subunit in Calpain I, and calpain 2 subunit in Calpain II), and a common small regulatory subunit encoded by this gene. This encoded protein is essential for the stability and function of both calpain heterodimers, whose proteolytic activities influence various cellular functions including Apoptosis, proliferation, migration, adhesion, and Autophagy. Calpains have been implicated in neurodegenerative processes, such as myotonic dystrophy. A pseudogene of this gene has been defined on chromosome 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]

CAPNS1 Products(4)

mRNA	Protein	Name
NM_001003962.3	NP_001003962.1	calpain small subunit 1 isoform 1
NM_001302632.2	NP_001289561.1	calpain small subunit 1 isoform 1
NM_001302633.2	NP_001289562.1	calpain small subunit 1 isoform 2
NM_001749.4	NP_001740.1	calpain small subunit 1 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium-dependent cysteine-type endopeptidase activity	IDA IDA: Inferred from direct assay	17646163	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10639123	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of calpain complex	IPI IPI: Inferred from physical interaction	10639123	GOA
located in cytosol	IDA IDA: Inferred from direct assay	14559243	GOA
located in membrane	IDA IDA: Inferred from direct assay	14559243	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAPNS1 Protein Structure

EF-hand_8

EF-hand_6

0
100
200
268 a.a.

Protein Preferred Names

Protein Names

calpain small subunit 1

CANP small subunit

CAPNS1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CAPNS1	P04632	RASA1	Homo sapiens	P20936	Anti Bait CoIP	18761085
Intra	CAPNS1	P04632	RASA1	Homo sapiens	P20936	Competition Binding	18761085
Intra	CAPNS1	P04632	CAPN2	Homo sapiens	P17655	CD	28319173
Intra	CAPNS1	P04632	CAPN2	Homo sapiens	P17655	X-Ray Diffraction	10639123
Intra	CAPNS1	P04632	AGTRAP	Homo sapiens	Q6RW13	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Ulcer Of Lower Limbs

Ulcer Of Ankle	Ulcer Of Calf
Ulcer Of Heel And Midfoot	Ulcer Of Thigh
Ulcer Of Lower Limb

Limb-Girdle Muscular Dystrophy

Lgmd	Limb Girdle Muscular Dystrophy
Muscular Dystrophies, Limb-Girdle	Erb'S Muscular Dystrophy
Leyden-Mbius Muscular Dystrophy	Limb-Girdle Syndrome
Myopathic Limb-Girdle Syndrome	Limb Girdle
Muscular Dystrophy Limb-Girdle	Dystrophy, Muscular, Limb-Girdle
Lgmd - [Limb-Girdle Muscular Dystrophy]	Limb Girdle Muscle Dystrophy
Limb-Girdle Myopathy

Muscular Dystrophy

Muscular Dystrophies	Congenital Md
Congenital Muscular Dystrophy	Cmd
Mdc	Dystrophy, Muscular
Gower'S Muscular Dystrophy	Progressive Musclular Dystrophy
Pseudohypertrophic Atrophy	Pseudohypertrophic Muscle Paralysis
Pseudohypertrophic Muscular Atrophy	Pseudohypertrophic Muscular Dystrophy
Pseudohypertrophic Paralysis	Pseudomuscular Hypertrophy

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-158022	CTSL/CAPN1-IN-1	Inhibitor	/	Unkown
HY-161342	CTSL/CAPN1-IN-2	Inhibitor	/	Unkown
HY-RS01883	CAPN1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS01895	CAPNS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CAPNS1	MGD	MGI:88266
Rattus norvegicus	CAPNS1	RGD	RGD:2270
Bos taurus	CAPNS1	VGNC	VGNC:52184
Macaca mulatta	CAPNS1	VGNC	VGNC:108488
Canis familiaris	CAPNS1	VGNC	VGNC:53676

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