1. Gene
  2. FZD6 - frizzled class receptor 6 Gene

FZD6 - frizzled class receptor 6 Gene

Homo sapiens

Also known as FZ6; FZ-6; HFZ6; NDNC1; NDNC10

Gene ID: 8323 | Gene type: protein coding

About FZD6

Cytogenetic location: 8q22.3 Genomic coordinates (GRCh38): 8:103,298,494-103,332,866 (from NCBI)

This gene has 7 transcripts (splice variants), 202 orthologues, 15 paralogues and is associated with 3 phenotypes. Ubiquitous expression in thyroid (RPKM 15.4), lung (RPKM 14.1) and 25 other tissues.

Summary

This gene represents a member of the 'frizzled' gene family, which encode 7-transmembrane domain proteins that are receptors for Wnt signaling proteins. The protein encoded by this family member contains a signal peptide, a cysteine-rich domain in the N-terminal extracellular region, and seven transmembrane domains, but unlike other family members, this protein does not contain a C-terminal PDZ domain-binding motif. This protein functions as a negative regulator of the canonical Wnt/beta-catenin signaling cascade, thereby inhibiting the processes that trigger oncogenic transformation, cell proliferation, and inhibition of Apoptosis. Alternative splicing results in multiple transcript variants, some of which do not encode a protein with a predicted signal peptide.[provided by RefSeq, Aug 2011]

FZD6 Products(4)

mRNA Protein Name
NM_001164615.2 NP_001158087.1 frizzled-6 isoform a precursor
NM_001164616.2 NP_001158088.1 frizzled-6 isoform b
NM_001317796.2 NP_001304725.1 frizzled-6 isoform c
NM_003506.4 NP_003497.2 frizzled-6 isoform a precursor
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables Wnt receptor activity IDA
IDA: Inferred from direct assay
10347172 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
1927703 GOA
enables ubiquitin protein ligase binding IPI
IPI: Inferred from physical interaction
22575959 GOA
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of DNA-binding transcription factor activity IDA
IDA: Inferred from direct assay
14747478 GOA
involved in negative regulation of canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
14747478 GOA
involved in non-canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
14747478 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FZD6 Protein Structure

Fz

Fz: Fz domain (24 - 128)

Frizzled

Frizzled: Frizzled/Smoothened family membrane region (188 - 512)

  • 0
  • 200
  • 400
  • 600
  • 706 a.a.
Protein Preferred Names Protein Names

frizzled-6

frizzled 6, seven transmembrane spanning receptor

Recombinant FZD6 Proteins

Cat. No. Product Name Accession Purity
HY-P74134 Frizzled-6 Protein, Human (HEK293, His) O60353-1/NP_003497.2 (H19-V153) ≥95%
HY-P74135 Frizzled-6 Protein, Human (HEK293, Fc) O60353-1 (H19-V153) ≥95%

Related Diseases

Diseases Alias
Nail Disorder, Nonsyndromic Congenital, 1

Nonsyndromic Congenital Nail Disorder 1

Twenty-Nail Dystrophy

Claw-Shaped Nails

Nail Disorder, Nonsyndromic Congenital, 10

Onycholysis

NDNC1

Onychauxis, Hyponychia, And Onycholysis

Nonsyndromic Congenital Nail Disorder 10

Idiopathic Trachyonychia

Twenty Nail Dystrophy

Ndnc10

Onychodystrophy Totalis, Isolated

Nail Disorder, Nonsyndromic Congenital, 10, Formerly

Ndnc10, Formerly

Autosomal Dominant Nail Dysplasia

Nail Disorder, Nonsyndromic Congenital 1

Onychodystrophy Totalis

Sandpaper Nails

Trachyonychia

Nail Disorder, Non-Syndromic Congenital, 1

Nail Disorder, Non-Syndromic Congenital, 10

Onychauxis Hyponychia And Onycholysis

Nail Disorder, Nonsyndromic Congenital, Type 10

Detachment Of Nail

Separation Of Nail Plate

Nail Disease

Nail Diseases

Abnormality Of The Nail

Nail Anomaly

Autosomal Recessive Nail Dysplasia
Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos

Hydrops Fetalis, Nonimmune

Hydrops Fetalis

Non-Immune Hydrops Fetalis

NIHF

Familial Non-Immune Hydrops Fetalis

Hydrops Fetalis Nonimmune

Idiopathic Hydrops Fetalis

Hb Bart'S Hydrops Fetalis

Alpha-Thalassemia Hydrops Fetalis

Alpha-Thalassemia Major

Hemoglobin Bart'S Hydrops Fetalis

Homozygous Alpha0-Thalassemia

Fetal Anasarca

Fetal Hydrops

Generalized Fetal Edema

Hf

Non-Immune Hf

Non-Immune Fetal Edema

Non-Immune Fetal Hydrops

Hydrops Fetalis, Non-Immune

Hemoglobin Bart'S Hydrops Syndrome

Nonsyndromic Congenital Nail Disorder

Nail Disorder, Nonsyndromic Congenital

Tethered Spinal Cord Syndrome

Spinal Dysraphism

Tethered Cord Syndrome

Occult Spinal Dysraphism

Occult Spinal Dysraphism Sequence

Segmental Vertebral Anomalies

Tethered Spinal Cord Disease

Tethered Cord

Spina Bifida Occulta

Cryptomerorachischisis

Spina Bifida Occulta With Tethered Spinal Cord

Sbo - [Spina Bifida Occulta]

Myelomeningocele

Meningomyelocele

Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Robinow Syndrome

Acral Dysostosis With Facial And Genital Abnormalities

Fetal Face Syndrome

Robinow Dwarfism

Mesomelic Dwarfism-Small Genitalia Syndrome

Robinow-Silverman-Smith Syndrome

Costovertebral Segmentation Defect With Mesomelia

Covesdem Syndrome

Robinow'S Syndrome

Robinow-Silverman Syndrome

Anencephaly

Aprosencephaly

Anencephalus

Congenital Absence Of Brain

Absence Of A Large Part Of The Brain And The Skull

Anencephalia

Anencephalic Monster

Brain Absence

Brain Agenesis

Brain Aplasia

Absent Brain

Anencephalic

Congenital Absence Of Cerebrum

Congenital Hemicrania

Incomplete Anencephaly

Sacral Defect With Anterior Meningocele

Caudal Regression Syndrome

Caudal Regression Sequence

Sacral Agenesis

Caudal Dysgenesis Syndrome

SDAM

Caudal Dysplasia Sequence

Caudal Dysplasia

Sacral Agenesis Syndrome

Sacral Regression Syndrome

Sacral Defect And Anterior Sacral Meningocele

Rudd Klimek Syndrome

Sirenomelia

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

Exudative Vitreoretinopathy

Familial Exudative Vitreoretinopathy

Fevr

Criswick-Schepens Syndrome

Exudative Vitreoretinopathy, Familial

Vitreoretinopathy, Exudative )

Exudative Vitreoretinopathy 1

Strabismus

Strabismus, Susceptibility To

Strabismus, Susceptibility To, 1

Strabismus 1

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FZD6 RGD RGD:628816
Canis familiaris FZD6 VGNC VGNC:41034
Felis catus FZD6 VGNC VGNC:62406
Mus musculus FZD6 MGD MGI:108474
Macaca mulatta FZD6 VGNC VGNC:72837
Bos taurus FZD6 VGNC VGNC:29170
Others FZD6 NCBI