2. Gene
  3. FCRL5 - Fc receptor like 5 Gene

FCRL5 - Fc receptor like 5 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as CD307; FCRH5; IRTA2; BXMAS1; CD307e; PRO820

Gene ID: 83416 | Gene type: protein coding

About FCRL5

Cytogenetic location: 1q23.1 Genomic coordinates (GRCh38): 1:157,513,377-157,552,515 (from NCBI)

This gene has 8 transcripts (splice variants), 83 orthologues and 17 paralogues. Biased expression in lymph node (RPKM 14.3), spleen (RPKM 11.3) and 8 other tissues.

Summary

This gene encodes a member of the immunoglobulin receptor superfamily and the Fc-receptor like family. This gene and several Other Fc receptor-like gene members are clustered on the long arm of chromosome 1. The encoded protein is a single-pass type I membrane protein and contains 8 immunoglobulin-like C2-type domains. This gene is implicated in B cell development and lymphomagenesis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Sep 2010]

FCRL5 Products(2)

mRNA Protein Name
NM_001195388.2 NP_001182317.1 Fc receptor-like protein 5 isoform 2 precursor
NM_031281.3 NP_112571.2 Fc receptor-like protein 5 isoform 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables coreceptor activity IDA
IDA: Inferred from direct assay
30107486 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Reference Source
involved in B cell activation IDA
IDA: Inferred from direct assay
30107486 GOA
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
16849395 GOA
is active in plasma membrane IDA
IDA: Inferred from direct assay
16849395 GOA
part of receptor complex IDA
IDA: Inferred from direct assay
23382219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FCRL5 Protein Structure

Ig_2

Ig_2: Immunoglobulin domain (27 - 96)

Ig_2

Ig_2: Immunoglobulin domain (107 - 185)

Ig_2

Ig_2: Immunoglobulin domain (192 - 273)

Ig_2

Ig_2: Immunoglobulin domain (287 - 373)

Ig_2

Ig_2: Immunoglobulin domain (380 - 466)

Ig_2

Ig_2: Immunoglobulin domain (473 - 559)

Ig_3

Ig_3: Immunoglobulin domain (565 - 638)

Ig_3

Ig_3: Immunoglobulin domain (658 - 731)

Ig_2

Ig_2: Immunoglobulin domain (755 - 835)

  • 0
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  • 800
  • 977 a.a.
Protein Preferred Names Protein Names

Fc receptor-like protein 5

fc receptor homolog 5

FCRL5 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
FCRL5 Q96RD9 CAGE1 Homo sapiens Q8TC20-4
Y2H Array
32296183
Intra
FCRL5 Q96RD9 CAGE1 Homo sapiens Q8TC20-4
Y2H Prey Pooling
32296183
Intra
FCRL5 Q96RD9 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
32296183
Intra
FCRL5 Q96RD9 USHBP1 Homo sapiens Q8N6Y0
Y2H Array
32296183
Intra
FCRL5 Q96RD9 AMOTL2 Homo sapiens Q9Y2J4
Validated Y2H
32296183
Intra
FCRL5 Q96RD9 AMOTL2 Homo sapiens Q9Y2J4
Y2H Array
32296183
Intra
FCRL5 Q96RD9 AMOTL2 Homo sapiens Q9Y2J4
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FCRL5 Proteins

Cat. No. Product Name Accession Purity
HY-P77651 FcRH5/FcRL5 Protein, Human (HEK293, His-Avi) Q96RD9-1 (Q16-G851) ≥95%
HY-P700302 FcRH5/FcRL5 Protein, Human (HEK293, His) Q96RD9-1 (Q16-G851) > 95% as determined by Tris-Bis PAGE.

Related Diseases

Diseases Alias
Hairy Cell Leukemia

Hcl-V

Hairy Cell Leukemia Variant

Hairy Cell Leukaemia Variant

Hcl

Leukemic Reticuloendotheliosis

Leukemic Reticuloendotheliosis Variant

Prolymphocytic Variant Of Hcl

Prolymphocytic Variant Of Hairy Cell Leukemia

Leukemia Hairy Cell

Leukemia, Hairy Cell

Leukaemic Reticuloendotheliosis

Lre - [Leukemic Reticuloendotheliosis]

Hairy-Cell Leukaemia, Nos

Hcl - [Hairy Cell Leukaemia]

Hairy-Cell Leukaemia Without Mention Of Remission
Lymphoma

Lymphoid Cancer

Lymphomas

Lymphoid Cancers

Lymphoid Neoplasm

Lymphoma Nos

Nhl - [Non-Hodgkin Lymphoma]

Non-Hodgkin Lymphoma

Non-Hodgkin Lymphoma, Nos

Non-Hodgkin Malignant Lymphoma Nos
Burkitt Lymphoma

Burkitt'S Lymphoma

BL

Burkitt Lymphoma, Somatic

Burkitt Lymphoma/Leukaemia

Burkitt'S Tumor

Burkitt'S Tumor Or Lymphoma

Malignant Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma, Burkitt'S Type

Small Non-Cleaved Cell Lymphoma

Burkitt Tumor

Burkitts Lymphoma

Lymphoma, Small Noncleaved-Cell

Burkitt Tumour

Diffuse Small Noncleaved Malignant Burkitt Lymphoma

Malignant Burkitt Lymphoma

“Burkitt-Like” Lymphoma

Undifferentiated Burkitt Lymphoma

Small Noncleaved Cell Burkitt Lymphoma
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-160799 HA-9104 Inducer 98.06% Unkown
HY-RS04846 FCRL5 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus FCRL5 RGD RGD:1589379
Bos taurus FCRL5 VGNC VGNC:59181
Canis familiaris FCRL5 VGNC VGNC:49722
Felis catus FCRL5 VGNC VGNC:62216
Macaca mulatta FCRL5 VGNC VGNC:99950
Mus musculus FCRL5 MGD MGI:3053558
Macaca fascicularis FCRL5 NCBI NCBI:102119391
Others FCRL5 NCBI