AMOTL2 - angiomotin like 2 Gene

Homo sapiens

Also known as LCCP

Gene ID: 51421 | Gene type: protein coding

About AMOTL2

Cytogenetic location: 3q22.2 Genomic coordinates (GRCh38): 3:134,355,345-134,375,417 (from NCBI)

This gene has 13 transcripts (splice variants), 267 orthologues and 2 paralogues. Ubiquitous expression in fat (RPKM 33.7), placenta (RPKM 20.8) and 24 other tissues.

Summary

Angiomotin is a protein that binds angiostatin, a circulating inhibitor of the formation of new blood vessels (angiogenesis). Angiomotin mediates angiostatin inhibition of endothelial cell migration and tube formation in vitro. The protein encoded by this gene is related to angiomotin and is a member of the motin protein family. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]

AMOTL2 Products(4)

mRNA	Protein	Name
NM_001278683.1	NP_001265612.1	angiomotin-like protein 2 isoform 1
NM_001278685.2	NP_001265614.1	angiomotin-like protein 2 isoform 3
NM_001363943.2	NP_001350872.1	angiomotin-like protein 2 isoform 4
NM_016201.4	NP_057285.3	angiomotin-like protein 2 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16189514	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in positive regulation of protein localization	IDA IDA: Inferred from direct assay	23911299	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	23911299	GOA
located in podosome	IDA IDA: Inferred from direct assay	23525008	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

AMOTL2 Protein Structure

Angiomotin_C

0
200
400
600
779 a.a.

Protein Preferred Names

Protein Names

angiomotin-like protein 2

Leman coiled-coil protein

AMOTL2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	AMOTL2	Q9Y2J4	RAD51D	Homo sapiens	O75771	Y2H Array	31515488
Intra	AMOTL2	Q9Y2J4	SH3RF2	Homo sapiens	Q8TEC5	Y2H Array	31515488
Intra	AMOTL2	Q9Y2J4	RNF20	Homo sapiens	Q5VTR2	Y2H Array	31515488
Intra	AMOTL2	Q9Y2J4	PSMC3	Homo sapiens	P17980	Anti Tag CoIP	24255178
Intra	AMOTL2	Q9Y2J4	GSTM5	Homo sapiens	P46439	Y2H Array	31515488
Intra	AMOTL2	Q9Y2J4	NDC80	Homo sapiens	O14777	Y2H Array	29892012
Intra	AMOTL2	Q9Y2J4	NDC80	Homo sapiens	O14777	Y2H Array	31515488
Intra	AMOTL2	Q9Y2J4	NME7	Homo sapiens	Q9Y5B8	Validated Y2H	32296183
Intra	AMOTL2	Q9Y2J4	MAGOHB	Homo sapiens	Q96A72	Y2H Pooling	16189514

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Meningioma, Familial

Meningioma	Familial Meningioma
Meningioma, Familial, Susceptibility To	Meningeal Neoplasm
Meningeal Neoplasms	Meningiomas
Meningioma, Nf2-Related, Somatic	Meningioma, Sis-Related
Meningothelial Cell Tumor	Neoplasm Of The Meninges
Primary Meningeal Tumor	Familial Multiple Meningioma
MNGMA	Meningioma, Benign, No Icd-O Subtype
Intracranial Meningioma	Meningothelial Cell Neoplasm
Supratentorial Meningioma	Primary Neoplasm Of Spinal Meninges
Benign Intracranial Meningioma	Benign Meningioma
Meningeal Tumours	Meningeal Sarcoma Of Unspecified Site
Meningothelial Sarcoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00665	AMOTL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	AMOTL2	VGNC	VGNC:37837
Rattus norvegicus	AMOTL2	RGD	RGD:70977
Bos taurus	AMOTL2	VGNC	VGNC:25872
Felis catus	AMOTL2	VGNC	VGNC:59771
Mus musculus	AMOTL2	MGD	MGI:1929286

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