ARHGAP24 - Rho GTPase activating protein 24 Gene

Homo sapiens

Also known as p73; FILGAP; RCGAP72; RC-GAP72; p73RhoGAP

Gene ID: 83478 | Gene type: protein coding

About ARHGAP24

Cytogenetic location: 4q21.23-q21.3 Genomic coordinates (GRCh38): 4:85,475,150-86,002,666 (from NCBI)

This gene has 12 transcripts (splice variants), 201 orthologues, 2 paralogues and is associated with 1 phenotype. Broad expression in kidney (RPKM 13.8), thyroid (RPKM 4.3) and 20 other tissues.

Summary

This gene encodes a Rho-GTPase activating protein, which is specific for the small GTPase family member Rac. Binding of the encoded protein by filamin A targets it to sites of membrane protrusion, where it antognizes Rac. This results in suppression of lamellae formation and promotion of retraction to regulate cell polarity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]

ARHGAP24 Products(5)

mRNA	Protein	Name
NM_001025616.3	NP_001020787.2	rho GTPase-activating protein 24 isoform 1
NM_001042669.2	NP_001036134.1	rho GTPase-activating protein 24 isoform 3
NM_001287805.2	NP_001274734.1	rho GTPase-activating protein 24 isoform 4
NM_001346093.2	NP_001333022.1	rho GTPase-activating protein 24 isoform 5
NM_031305.3	NP_112595.2	rho GTPase-activating protein 24 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	16862148	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ARHGAP24 Protein Structure

RhoGAP

0
200
400
600
748 a.a.

Protein Preferred Names

Protein Names

rho GTPase-activating protein 24

RAC1- and CDC42-specific GTPase-activating protein of 72 kDa

ARHGAP24 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ARHGAP24	Q8N264	FLNA	Homo sapiens	P21333	Anti Bait CoIP	16862148
Intra	ARHGAP24	Q8N264	FLNA	Homo sapiens	P21333	Y2H	16862148
Intra	ARHGAP24	Q8N264	FLNA	Homo sapiens	P21333	Pull Down	16862148
Intra	ARHGAP24	Q8N264	FLNA	Homo sapiens	P21333	IF	16862148
Intra	ARHGAP24	Q8N264	HTT	Homo sapiens	P42858	Y2H	17500595

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Genetic Steroid-Resistant Nephrotic Syndrome

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Genetic Srns
Hereditary Steroid-Resistant Nephrotic Syndrome	Familial Idiopathic Nephrotic Syndrome
Nephrotic Syndrome, Steroid-Resistant, Autosomal Recessive	Srn1

Tarp Syndrome

TARPS	Pierre Robin Syndrome With Congenital Heart Malformation And Clubfoot
Pierre Robin Sequence-Congenital Heart Defect-Talipes Syndrome	Pierre Robin Syndrome-Congenital Heart Defect-Talipes Syndrome
Talipes Equinovarus-Atrial Septal Defect-Robin Sequence-Persistence Of The Left Superior Vena Cava Syndrome	Talipes Equinovarus, Atrial Septal Defect, Robin Sequence, And Persistence Of Left Superior Vena Cava
Pierre Robin Sequence - Congenital Heart Defect - Talipes	Pierre Robin Syndrome - Congenital Heart Defect - Talipes
Talipes Equinovarus - Atrial Septal Defect - Robin Sequence - Persistence Of The Left Superior Vena Cava	Talipes Equinovarus Atrial Septal Defect Robin Sequence And Persistence Of Left Superior Vena Cava

Melnick-Needles Syndrome

MNS	Melnick-Needles Osteodysplasty
Osteodysplasty Of Melnick And Needles	Osteochondrodysplasias

Frasier Syndrome

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Alport Syndrome

Hereditary Nephritis	Alport Syndrome, X-Linked
Hemorrhagic Hereditary Nephritis	Congenital Hereditary Hematuria
Hemorrhagic Familial Nephritis	Familial Nephritis
Thin Basement Membrane Disease	Thin Basement Membrane Nephropathy
Hematuria-Nephropathy-Deafness Syndrome	Hematuric Hereditary Nephritis
Hereditary Familial Congenital Hemorrhagic Nephritis	Hereditary Hematuria Syndrome
Hereditary Interstitial Pyelonephritis	Alport Deafness-Nephropathy
Alport Hearing Loss-Nephropathy	Alports Syndrome
Nephritis, Hereditary

Periventricular Nodular Heterotopia

Periventricular Heterotopia	Pvnh
Familial Nodular Heterotopia	Heterotopia, Periventricular
Periventricular Heterotopia, X-Linked

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00924	ARHGAP24 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	ARHGAP24	VGNC	VGNC:69904
Mus musculus	ARHGAP24	MGD	MGI:1922647
Rattus norvegicus	ARHGAP24	RGD	RGD:1306669
Canis familiaris	ARHGAP24	VGNC	VGNC:38053
Bos taurus	ARHGAP24	VGNC	VGNC:26082
Felis catus	ARHGAP24	VGNC	VGNC:59881

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