2. Gene
  3. Thbd - thrombomodulin Gene

Thbd - thrombomodulin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 83580 | Gene type: protein coding

About Thbd

Summary

Predicted to enable calcium ion binding activity and transmembrane signaling receptor activity. Involved in response to X-ray; response to cAMP; and response to lipopolysaccharide. Located in apicolateral plasma membrane; extracellular space; and vacuolar membrane. Used to study acute kidney failure. Biomarker of adult respiratory distress syndrome; hypertension; ischemia; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including acute kidney failure; atypical hemolytic-uremic syndrome; cerebrovascular disease (multiple); rheumatoid arthritis; and thrombophilia (multiple). Orthologous to human THBD (thrombomodulin). [provided by Alliance of Genome Resources, Apr 2022]

Thbd Products(1)

mRNA Protein Name
NM_031771.2 NP_113959.1 thrombomodulin precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in response to X-ray IEP
IEP: Inferred from expression pattern
12057911 RGD
involved in response to cAMP IEP
IEP: Inferred from expression pattern
17090405 RGD
involved in response to lipopolysaccharide IEP
IEP: Inferred from expression pattern
12611420 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apicolateral plasma membrane IDA
IDA: Inferred from direct assay
9272431 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
12611420 RGD
located in vacuolar membrane IDA
IDA: Inferred from direct assay
9272431 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thrombomodulin

thrombomdulin

Recombinant Thbd Proteins

Cat. No. Product Name Accession Purity
HY-P74519 Thrombomodulin Protein, Rat (HEK293, His) O35370 (I17-S517) ≥95%

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14478 THBD Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Thbd NCBI NCBI:7056
Mus musculus Thbd NCBI NCBI:21824