BCL2L12 - BCL2 like 12 Gene

Homo sapiens

Gene ID: 83596 | Gene type: protein coding

About BCL2L12

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:49,665,142-49,673,916 (from NCBI)

This gene has 19 transcripts (splice variants), 153 orthologues, 1 paralogue and is associated with 49 phenotypes. Ubiquitous expression in lymph node (RPKM 7.1), spleen (RPKM 6.8) and 25 other tissues.

Summary

This gene encodes a member of a family of proteins containing a Bcl-2 homology domain 2 (BH2). The encoded protein is an anti-apoptotic factor that acts as an inhibitor of caspases 3 and 7 in the cytoplasm. In the nucleus, it binds to the p53 tumor suppressor protein, preventing its association with target genes. Overexpression of this gene has been detected in a number of different cancers. There is a pseudogene for this gene on chromosome 3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

BCL2L12 Products(8)

mRNA	Protein	Name
NM_001040668.2	NP_001035758.2	bcl-2-like protein 12 isoform 3
NM_001282516.2	NP_001269445.2	bcl-2-like protein 12 isoform 4
NM_001282517.2	NP_001269446.2	bcl-2-like protein 12 isoform 2
NM_001282519.2	NP_001269448.2	bcl-2-like protein 12 isoform 5
NM_001282520.1	NP_001269449.1	bcl-2-like protein 12 isoform 6
NM_001282521.2	NP_001269450.2	bcl-2-like protein 12 isoform 7
NM_001385706.1	NP_001372635.1	bcl-2-like protein 12 isoform 8
NM_138639.2	NP_619580.2	bcl-2-like protein 12 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	19376117	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in inhibition of cysteine-type endopeptidase activity involved in apoptotic process	IDA IDA: Inferred from direct assay	22262180	GOA
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	22262180	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	20837658	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

bcl-2-like protein 12

BCL2-like 12 (proline rich)

BCL2L12 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	BCL2L12	Q9HB09	BAX	Homo sapiens	Q07812	Anti Tag CoIP	33961781

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant BCL2L12 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76165	BCL2L12 Protein, Human (GST)	Q9HB09-1 (P64-K143)	≥95%

Related Diseases

Diseases

Alias

Skin Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Skin	Epidermoid Skin Carcinoma
Squamous Cell Carcinoma Of The Skin	Squamous Cell Epithelioma Of Skin
Cutaneous Squamous Cell Carcinoma	Scc - [Squamous Cell Carcinoma] Of Skin

Skin Melanoma

Cutaneous Melanoma	Malignant Ear Melanoma
Malignant Lip Melanoma	Malignant Lower Limb Melanoma
Malignant Melanoma Of Ear And/Or External Auricular Canal	Malignant Melanoma Of Skin Of Lower Limb
Malignant Melanoma Of Skin Of Trunk Except Scrotum	Malignant Melanoma Of Skin Of Upper Limb
Malignant Neck Melanoma	Malignant Scalp Melanoma
Malignant Trunk Melanoma	Malignant Upper Limb Melanoma
Melanoma, Cutaneous Malignant	Melanoma
Malignant Melanoma Of Skin	Melanoma Nos
Malignant Mole, Meaning Melanoma Of Unspecified Site	Melanoma Of Unspecified Site
Cutaneous Malignant Melanoma	Mm - [Malignant Melanoma]

Autoimmune Lymphoproliferative Syndrome, Type Iii

ALPS3	Autoimmune Lymphoproliferative Syndrome Type 3
Immunodeficiency, Common Variable, 9, Formerly	Cvid9, Formerly
Autoimmune Lymphoproliferative Syndrome Type Iii	Autoimmune Lymphoproliferative Syndrome 3
Cvid9	Immunodeficiency, Common Variable, 9
Type 3 Autoimmune Lymphoproliferative Syndrome	Immunodeficiency, Variable, Common, Type 9

Laryngeal Benign Neoplasm

Laryngeal Tumor	Larynx Neoplasm
Neoplasm Of Larynx	Laryngeal Cancer
Laryngeal Carcinoma	Cancer Of Larynx

Gliosarcoma

Glioblastoma With Sarcomatous Component

Sarcomatous Glioblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149622	Bcl-2-IN-12	Inhibitor	/	Unkown
HY-RS01430	BCL2L12 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	BCL2L12	MGD	MGI:1922986
Rattus norvegicus	BCL2L12	RGD	RGD:1307361
Bos taurus	BCL2L12	VGNC	VGNC:26447
Macaca mulatta	BCL2L12	VGNC	VGNC:103792
Canis familiaris	BCL2L12	VGNC	VGNC:53525
Others	BCL2L12	NCBI

Name
Email *

	Sorry, but the email address you supplied was invalid.