ATG10 - autophagy related 10 Gene

Homo sapiens

Also known as APG10; APG10L; pp12616

Gene ID: 83734 | Gene type: protein coding

About ATG10

Cytogenetic location: 5q14.1-q14.2 Genomic coordinates (GRCh38): 5:81,972,023-82,256,133 (from NCBI)

This gene has 9 transcripts (splice variants) and 195 orthologues. Ubiquitous expression in testis (RPKM 1.1), thyroid (RPKM 0.8) and 25 other tissues.

Summary

Autophagy is a process for the bulk degradation of cytosolic compartments by lysosomes. ATG10 is an E2-like Enzyme involved in 2 ubiquitin-like modifications essential for autophagosome formation: ATG12 (MIM 609608)-ATG5 (MIM 604261) conjugation and modification of a soluble form of MAP-LC3 (MAP1LC3A; MIM 601242), a homolog of yeast Apg8, to a membrane-bound form (Nemoto et al., 2003 [PubMed 12890687]).[supplied by OMIM, Mar 2008]

ATG10 Products(2)

mRNA	Protein	Name
NM_001131028.2	NP_001124500.1	ubiquitin-like-conjugating enzyme ATG10
NM_031482.5	NP_113670.1	ubiquitin-like-conjugating enzyme ATG10

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables Atg12 conjugating enzyme activity	IDA IDA: Inferred from direct assay	16963840	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in ER overload response	IMP IMP: Inferred from mutant phenotype	17256008	GOA
involved in autophagosome assembly	IDA IDA: Inferred from direct assay	16963840	GOA
involved in autophagy	IMP IMP: Inferred from mutant phenotype	15657430	GOA
involved in protein modification by small protein conjugation	IDA IDA: Inferred from direct assay	16963840	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ATG10 Protein Structure

Autophagy_act_C

0
100
200
220 a.a.

Protein Preferred Names

Protein Names

ubiquitin-like-conjugating enzyme ATG10

APG10 autophagy 10-like

ATG10 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	ATG10	Q9H0Y0	ATG5	Homo sapiens	Q9H1Y0	Validated Y2H	32296183

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Neurodegeneration With Brain Iron Accumulation

Nbia	Neurodegeneration With Brain Iron Accumulation Disorders
Neurodegeneration, With Brain Iron Accumulation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01138	ATG10 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	ATG10	VGNC	VGNC:26248
Mus musculus	ATG10	MGD	MGI:1914045
Felis catus	ATG10	VGNC	VGNC:102164
Macaca mulatta	ATG10	VGNC	VGNC:70102
Canis familiaris	ATG10	VGNC	VGNC:38214
Rattus norvegicus	ATG10	RGD	RGD:1587624
Others	ATG10	NCBI

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