2. Gene
  3. SPNS1 - SPNS lysolipid transporter 1, lysophospholipid Gene

SPNS1 - SPNS lysolipid transporter 1, lysophospholipid Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as LAT; nrs; SPIN1; SPINL; HSpin1; PP2030; SLC62A1; SLC63A1

Gene ID: 83985 | Gene type: protein coding

About SPNS1

Cytogenetic location: 16p11.2 Genomic coordinates (GRCh38): 16:28,974,778-28,984,765 (from NCBI)

This gene has 12 transcripts (splice variants), 191 orthologues and 2 paralogues. Ubiquitous expression in lung (RPKM 11.3), placenta (RPKM 11.2) and 25 other tissues.

Summary

Predicted to enable transmembrane transporter activity. Predicted to be involved in lipid transport and transmembrane transport. Located in lysosomal membrane. [provided by Alliance of Genome Resources, Apr 2022]

SPNS1 Products(5)

mRNA Protein Name
NM_001142448.2 NP_001135920.1 protein spinster homolog 1 isoform 1
NM_001142449.2 NP_001135921.1 protein spinster homolog 1 isoform 4
NM_001142450.2 NP_001135922.1 protein spinster homolog 1 isoform 2
NM_001142451.2 NP_001135923.1 protein spinster homolog 1 isoform 3
NM_032038.3 NP_114427.1 protein spinster homolog 1 isoform 1

SPNS1 Protein Structure

MFS_1

MFS_1: Major Facilitator Superfamily (68 - 415)

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  • 528 a.a.
Protein Preferred Names Protein Names

protein spinster homolog 1

SPNS sphingolipid transporter 1 (putative)

SPNS1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra SPNS1 Q9H2V7 BCL2L1 Homo sapiens Q07817
Anti Tag CoIP
12815463
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Noonan Syndrome 4

NS4

Noonan Syndrome, Type 4
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS13690 SPNS1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris SPNS1 VGNC VGNC:53538
Mus musculus SPNS1 MGD MGI:1920908
Felis catus SPNS1 VGNC VGNC:80683
Rattus norvegicus SPNS1 RGD RGD:1305613
Macaca mulatta SPNS1 VGNC VGNC:99593