SPARCL1 - SPARC like 1 Gene

Homo sapiens

Also known as SC1; MAST9; PIG33; MAST 9

Gene ID: 8404 | Gene type: protein coding

About SPARCL1

Cytogenetic location: 4q22.1 Genomic coordinates (GRCh38): 4:87,473,335-87,529,376 (from NCBI)

This gene has 10 transcripts (splice variants), 192 orthologues and 1 paralogue. Broad expression in brain (RPKM 777.2), endometrium (RPKM 500.6) and 20 other tissues.

Summary

Predicted to enable calcium ion binding activity; collagen binding activity; and extracellular matrix binding activity. Predicted to be involved in anatomical structure development and regulation of synapse organization. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SPARCL1 Products(4)

mRNA	Protein	Name
NM_001128310.3	NP_001121782.1	SPARC-like protein 1 isoform 1 precursor
NM_001291976.2	NP_001278905.1	SPARC-like protein 1 isoform 2
NM_001291977.2	NP_001278906.1	SPARC-like protein 1 isoform 2
NM_004684.6	NP_004675.3	SPARC-like protein 1 isoform 1 precursor

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	20926826	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SPARCL1 Protein Structure

FOLN

Kazal_1

SPARC_Ca_bdg

0
200
400
600
664 a.a.

Protein Preferred Names

Protein Names

SPARC-like protein 1

SPARC-like 1 (hevin)

Related Diseases

Diseases

Alias

Pancreatic Cancer

Pancreatic Carcinoma	Carcinoma Of Pancreas
Familial Pancreatic Carcinoma	Pancreatic Neoplasm
Pancreatic Carcinoma, Familial	Malignant Neoplasm Of Pancreas
Pancreatic Acinar Carcinoma	Pancreatic Tumor
Familial Pancreatic Cancer	Neoplasm Of The Pancreas
Cancer Of The Pancreas	Pancreatic Carcinoma, Somatic
Pancreatic Cancer, Somatic	Ca Body Of Pancreas
Ca Head Of Pancreas	Ca Tail Of Pancreas
Malignant Neoplasm Of Body Of Pancreas	Malignant Neoplasm Of Head Of Pancreas
Malignant Neoplasm Of Tail Of Pancreas	Pancreas Neoplasm
Exocrine Cancer	Exocrine Pancreas Carcinoma
Hereditary Pancreatic Cancer	Hereditary Pancreatic Carcinoma
PNCA	Pancreatic Cancer, Susceptibility To
Carcinoma Of Head Of Pancreas	Pancreatic Neoplasms
Pancreatic Tumors	Cancer, Pancreatic
Cancer Of Pancreas	Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13632	SPARCL1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SPARCL1	RGD	RGD:2531
Felis catus	SPARCL1	VGNC	VGNC:65602
Bos taurus	SPARCL1	VGNC	VGNC:35172
Macaca mulatta	SPARCL1	VGNC	VGNC:77855
Mus musculus	SPARCL1	MGD	MGI:108110
Others	SPARCL1	NCBI

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