KIRREL2 - kirre like nephrin family adhesion molecule 2 Gene

Homo sapiens

Also known as NLG1; NEPH3; FILTRIN

Gene ID: 84063 | Gene type: protein coding

About KIRREL2

Cytogenetic location: 19q13.12 Genomic coordinates (GRCh38): 19:35,851,399-35,867,136 (from NCBI)

This gene has 5 transcripts (splice variants), 192 orthologues and 3 paralogues. Biased expression in pancreas (RPKM 5.8), kidney (RPKM 0.6) and 3 other tissues.

Summary

This gene encodes a type I transmembrane protein and member of the immunoglobulin superfamily of cell adhesion molecules. The encoded protein localizes to adherens junctions in pancreatic beta cells and regulates Insulin secretion. Autoantibodies against the encoded protein have been detected in serum from patients with type 1 diabetes. This gene may also play a role in glomerular development and decreased expression of this gene has been observed in human glomerular diseases. This gene and the related opposite-strand gene nephrin (GeneID: 527362) are regulated by a bidirectional promoter. [provided by RefSeq, Jul 2016]

KIRREL2 Products(5)

mRNA	Protein	Name
NM_001329530.2	NP_001316459.1	kin of IRRE-like protein 2 isoform d precursor
NM_001363667.2	NP_001350596.1	kin of IRRE-like protein 2 isoform e precursor
NM_032123.7	NP_115499.5	kin of IRRE-like protein 2 isoform a precursor
NM_199179.4	NP_954648.3	kin of IRRE-like protein 2 isoform b precursor
NM_199180.4	NP_954649.3	kin of IRRE-like protein 2 isoform c precursor

Protein Preferred Names

Protein Names

kin of IRRE-like protein 2

kin of IRRE like 2

Recombinant KIRREL2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77043	KIRREL2/NEPH3 Protein, Human (HEK293, Fc)	Q6UWL6-1 (G21-R503)	≥95%
HY-P77044	KIRREL2/NEPH3 Protein, Human (HEK293, His)	Q6UWL6-1 (G21-R503)	≥95%

Related Diseases

Diseases

Alias

Nephrotic Syndrome, Type 1

Finnish Congenital Nephrosis	NPHS1
Cnf	Finnish Congenital Nephrotic Syndrome
Nephrotic Syndrome Type 1	Nephrosis, Congenital
Congenital Nephrotic Syndrome	Nephrotic Syndrome, Congenital
Congenital Nephrotic Syndrome Finnish Type	Congenital Nephrotic Syndrome 1
Nephrosis 1, Congenital, Finnish Type	Congenital Nephrotic Syndrome, Finnish Type
Nephrotic Syndrome 1	Congenital Nephrotic Syndrome Of The Finnish Type

Nephrotic Syndrome

Finnish Congenital Nephrotic Syndrome	Ns - [Nephrotic Syndrome]
Nephrosis Syndrome	Nephrosis Nos
Glomerular Lesion Nephrosis

Basan Syndrome

Adermatoglyphia With Congenital Facial Milia And Acral Blisters, Digital Contractures, And Nail Abnormalities	Ectodermal Dysplasia, Absent Dermatoglyphic Pattern, Changes In Nails, And Simian Crease
Baird Syndrome	Absence Of Fingerprints-Congenital Milia Syndrome
Absence Of Fingerprints Congenital Milia	Absence Of Dermatoglyphics Congenital Milia
Absence Of Dermatoglyphics-Congenital Milia Syndrome	Basan-Baird Syndrome
BSNS	Adermatoglyphia, Congenital Facial Milia, Acral Blisters, Digital Contractures, Nail Abnormalities

Familial Nephrotic Syndrome

Congenital Nephrotic Syndrome	Nephrosis, Congenital
Finnish Congenital Nephrotic Syndrome

Focal Segmental Glomerulosclerosis

Familial Idiopathic Steroid-Resistant Nephrotic Syndrome	Focal Glomerulosclerosis
Fsgs	Segmental Glomerulosclerosis
Glomerulosclerosis, Focal Segmental	Fgs
Focal Glomerular Sclerosis	Familial Idiopathic Nephrotic Syndrome
Focal Sclerosis With Hyalinosis	Glomerulosclerosis, Focal
Glomerulosclerosis Focal	Glomerulosclerosis, Segmental, Focal
Focal Segmental Glomerulosclerosis, Not Otherwise Specified

Hematuria, Benign Familial

Benign Familial Hematuria	BFH
Thin Membrane Nephropathy	Tmn
Thin Basement Membrane Nephropathy	Thin-Basement-Membrane Nephropathy
Hematuria, Familial Benign	Hematuria Benign Familial
Hematuria, Benign, Familial	Thin Basement Membrane Disease

Autosomal Dominant Alport Syndrome

Alport Syndrome, Autosomal Dominant	Alport Syndrome Dominant Type
Renal Failure And Sensorineural Hearing Loss	Alport Syndrome, Dominant Type

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07313	KIRREL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KIRREL2	VGNC	VGNC:97781
Mus musculus	KIRREL2	MGD	MGI:2442334
Canis familiaris	KIRREL2	VGNC	VGNC:42419
Rattus norvegicus	KIRREL2	RGD	RGD:1308456
Felis catus	KIRREL2	VGNC	VGNC:63123
Bos taurus	KIRREL2	VGNC	VGNC:30615
Others	KIRREL2	NCBI

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