USP42 - ubiquitin specific peptidase 42 Gene

Homo sapiens

Gene ID: 84132 | Gene type: protein coding

About USP42

This gene has 7 transcripts (splice variants), 255 orthologues and 71 paralogues. Broad expression in testis (RPKM 9.2), bone marrow (RPKM 4.1) and 24 other tissues.

Summary

Enables thiol-dependent Deubiquitinase. Involved in protein deubiquitination. Predicted to be located in nucleoplasm. Predicted to be active in cytosol and nucleus. [provided by Alliance of Genome Resources, Apr 2022]

USP42 Products(3)

mRNA	Protein	Name
NM_001365764.1	NP_001352693.1	ubiquitin carboxyl-terminal hydrolase 42 isoform 1
NM_001389650.1	NP_001376579.1	ubiquitin carboxyl-terminal hydrolase 42 isoform 3
NM_032172.3	NP_115548.1	ubiquitin carboxyl-terminal hydrolase 42 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables cysteine-type deubiquitinase activity	IDA IDA: Inferred from direct assay	14715245	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	22085928	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

USP42 Protein Structure

UCH

0
300
600
900
1200
1316 a.a.

Protein Preferred Names

Protein Names

ubiquitin carboxyl-terminal hydrolase 42

deubiquitinating enzyme 42

USP42 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	USP42	Q9H9J4	TP53	Homo sapiens	P04637	Anti Bait CoIP	22085928

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Deafness, Autosomal Dominant 21

DFNA21	Autosomal Dominant Nonsyndromic Deafness 21
Autosomal Dominant Deafness 21	Deafness, Autosomal Dominant, 21

Myelodysplastic Syndrome

Myelodysplastic Syndromes	Myelodysplasia
MDS	Myelodysplastic Syndrome Included
Myelodysplastic Syndrome, Susceptibility To, Included	Myelodysplastic Syndrome, Somatic
Myelodysplastic Syndrome, Susceptibility To

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS15553	USP42 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	USP42	VGNC	VGNC:50065
Macaca mulatta	USP42	VGNC	VGNC:79225
Canis familiaris	USP42	VGNC	VGNC:54087
Mus musculus	USP42	MGD	MGI:1924050
Rattus norvegicus	USP42	RGD	RGD:1305231
Felis catus	USP42	VGNC	VGNC:107828

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