POLR1B - RNA polymerase I subunit B Gene

Homo sapiens

Also known as A135; RPA2; TCS4; RPA135; Rpo1-2

Gene ID: 84172 | Gene type: protein coding

About POLR1B

Cytogenetic location: 2q14.1 Genomic coordinates (GRCh38): 2:112,542,036-112,579,818 (from NCBI)

This gene has 17 transcripts (splice variants), 198 orthologues, 2 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 8.1), thyroid (RPKM 7.8) and 25 other tissues.

Summary

Eukaryotic RNA polymerase I (pol I) is responsible for the transcription of ribosomal RNA (rRNA) genes and production of rRNA, the primary component of ribosomes. Pol I is a multisubunit Enzyme composed of 6 to 14 polypeptides, depending on the species. Most of the mass of the pol I complex derives from the 2 largest subunits, Rpa1 and Rpa2 in yeast. POLR1B is homologous to Rpa2 (Seither and Grummt, 1996 [PubMed 8921381]).[supplied by OMIM, Mar 2008]

POLR1B Products(10)

mRNA	Protein	Name
NM_001137604.3	NP_001131076.1	DNA-directed RNA polymerase I subunit RPA2 isoform 2
NM_001282772.2	NP_001269701.1	DNA-directed RNA polymerase I subunit RPA2 isoform 3
NM_001282774.2	NP_001269703.1	DNA-directed RNA polymerase I subunit RPA2 isoform 4
NM_001282776.2	NP_001269705.1	DNA-directed RNA polymerase I subunit RPA2 isoform 5
NM_001282777.2	NP_001269706.1	DNA-directed RNA polymerase I subunit RPA2 isoform 6
NM_001282779.2	NP_001269708.1	DNA-directed RNA polymerase I subunit RPA2 isoform 6
NM_001371969.1	NP_001358898.1	DNA-directed RNA polymerase I subunit RPA2 isoform 7
NM_001371970.1	NP_001358899.1	DNA-directed RNA polymerase I subunit RPA2 isoform 6
NM_001371971.1	NP_001358900.1	DNA-directed RNA polymerase I subunit RPA2 isoform 5
NM_019014.6	NP_061887.2	DNA-directed RNA polymerase I subunit RPA2 isoform 1

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-directed 5'-3' RNA polymerase activity	IDA IDA: Inferred from direct assay	34671025	GOA
enables DNA/RNA hybrid binding	IDA IDA: Inferred from direct assay	34671025	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	16514417	GOA
enables zinc ion binding	IDA IDA: Inferred from direct assay	34671025	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of RNA polymerase I complex	IDA IDA: Inferred from direct assay	34671025	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

POLR1B Protein Structure

RNA_pol_Rpb2_1

RNA_pol_Rpb2_2

RNA_pol_Rpb2_3

RNA_pol_Rpa2_4

RNA_pol_Rpb2_5

RNA_pol_Rpb2_6

RNA_pol_Rpb2_7

0
200
400
600
800
1000
1135 a.a.

Protein Preferred Names

Protein Names

DNA-directed RNA polymerase I subunit RPA2

DNA-directed RNA polymerase I 135 kDa polypeptide

POLR1B Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	POLR1B	Q9H9Y6	POLR1A	Homo sapiens	O95602	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Treacher Collins Syndrome 4

TCS4	Treacher-Collins Syndrome 4

Treacher Collins Syndrome 1

Treacher Collins Syndrome	Mandibulofacial Dysostosis
Treacher Collins-Franceschetti Syndrome	Tcof
Tcs	Mfd1
Franceschetti-Klein Syndrome	TCS1
Franceschetti Syndrome	Franceschetti-Zwahlen-Klein Syndrome
Zygoauromandibular Dysplasia	Treacher-Collins Syndrome
Mandibulofacial Dysostosis Without Limb Anomalies	Bilateral And Symmetric Oto-Mandibular Dysplasia

Neurofibromatosis-Noonan Syndrome

NFNS	Neurofibromatosis Type 1
Neurofibromatosis With Noonan Phenotype	Nf1
Von Recklinghausen Disease	Neurofibromatosis Type 1-Noonan Syndrome
Noonan Neurofibromatosis Syndrome	Recklinghausen'S Disease
Noonan-Neurofibromatosis Syndrome	Fibromatosis Multiple Non Ossifying
Disseminated Nonossifying Fibromas In Association With Cafe-Au-Lait Spots	Jaffe Campanacci Syndrome
Type 1 Neurofibromatosis	Neurofibromatosis 1
Peripheral Neurofibromatosis	Recklinghausen Disease, Nerve
Jaffe-Campanacci Syndrome

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10838	POLR1B Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	POLR1B	VGNC	VGNC:44789
Felis catus	POLR1B	VGNC	VGNC:64286
Rattus norvegicus	POLR1B	RGD	RGD:620822
Macaca mulatta	POLR1B	VGNC	VGNC:76083
Bos taurus	POLR1B	VGNC	VGNC:33132
Mus musculus	POLR1B	MGD	MGI:108014

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