SLA2 - Src like adaptor 2 Gene

Homo sapiens

Also known as MARS; SLAP2; SLAP-2; C20orf156

Gene ID: 84174 | Gene type: protein coding

About SLA2

Cytogenetic location: 20q11.23 Genomic coordinates (GRCh38): 20:36,612,318-36,646,196 (from NCBI)

This gene has 2 transcripts (splice variants), 202 orthologues and 9 paralogues. Broad expression in lymph node (RPKM 4.0), bone marrow (RPKM 3.6) and 17 other tissues.

Summary

This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

SLA2 Products(2)

mRNA	Protein	Name
NM_032214.4	NP_115590.1	src-like-adapter 2 isoform a
NM_175077.3	NP_778252.1	src-like-adapter 2 isoform b

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11891219	GOA
enables signaling adaptor activity	IDA IDA: Inferred from direct assay	11891219	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of T cell activation	IDA IDA: Inferred from direct assay	11891219	GOA
involved in negative regulation of T cell receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	11891219	GOA
involved in negative regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	11696592	GOA
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	11696592	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLA2 Protein Structure

SH3_1

SH2

0
100
200
261 a.a.

Protein Preferred Names

Protein Names

src-like-adapter 2

Src-like adapter protein-2

SLA2 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	SLA2	Q9H6Q3	MET	Homo sapiens	P08581	FPS	24728074
Intra	SLA2	Q9H6Q3	KIT	Homo sapiens	P10721	FPS	24728074
Intra	SLA2	Q9H6Q3	GAB1	Homo sapiens	Q13480	FPS	24728074
Intra	SLA2	Q9H6Q3	ERBB2	Homo sapiens	P04626	Protein Array	16273093

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Phaeohyphomycosis

Infection By Dematiacious Fungi	Phaehyphomycosis
Phaeomycosis	Pheohyphomycosis
Infection By Dematiacious Fungi [Phaehyphomycosis]	Dematiaceous Fungal Infection

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12976	SLA2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Canis familiaris	SLA2	VGNC	VGNC:46203
Mus musculus	SLA2	MGD	MGI:1925049
Felis catus	SLA2	VGNC	VGNC:65174
Macaca mulatta	SLA2	VGNC	VGNC:77499
Bos taurus	SLA2	VGNC	VGNC:34651
Rattus norvegicus	SLA2	RGD	RGD:1562071

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