CAMKK1 - calcium/calmodulin dependent protein kinase kinase 1 Gene

Homo sapiens

Also known as CAMKKA

Gene ID: 84254 | Gene type: protein coding

About CAMKK1

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:3,860,315-3,893,053 (from NCBI)

This gene has 4 transcripts (splice variants), 268 orthologues and 22 paralogues. Broad expression in brain (RPKM 12.8), salivary gland (RPKM 4.6) and 24 other tissues.

Summary

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the CA(2+)/calmodulin-dependent protein kinase subfamily. This protein plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade. Three transcript variants encoding two distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

CAMKK1 Products(3)

mRNA	Protein	Name
NM_032294.3	NP_115670.1	calcium/calmodulin-dependent protein kinase kinase 1 isoform a
NM_172206.2	NP_757343.2	calcium/calmodulin-dependent protein kinase kinase 1 isoform c
NM_172207.3	NP_757344.2	calcium/calmodulin-dependent protein kinase kinase 1 isoform b

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18242179	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CAMKK1 Protein Structure

Pkinase

0
100
200
300
400
505 a.a.

Protein Preferred Names

Protein Names

calcium/calmodulin-dependent protein kinase kinase 1

CAMKK alpha protein

CAMKK1 Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	CAMKK1	Q8N5S9	YWHAH	Homo sapiens	Q04917	Pull Down	32707033
Intra	CAMKK1	Q8N5S9	YWHAE	Homo sapiens	P62258	Pull Down	32707033
Intra	CAMKK1	Q8N5S9	YWHAE	Homo sapiens	P62258	Crosslink	36931259

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Tracheitis

Acute Tracheitis	Chronic Tracheitis
Bacterial Tracheitis	Acute Tracheitis Nos
Tracheitis Nos	Tracheal Inflammation

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS01865	CAMKK1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CAMKK1	VGNC	VGNC:60336
Bos taurus	CAMKK1	VGNC	VGNC:26725
Rattus norvegicus	CAMKK1	RGD	RGD:62023
Mus musculus	CAMKK1	MGD	MGI:1891766
Canis familiaris	CAMKK1	VGNC	VGNC:38683
Macaca mulatta	CAMKK1	VGNC	VGNC:99125
Others	CAMKK1	NCBI

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