MON1A - MON1 homolog A, secretory trafficking associated Gene

Homo sapiens

Also known as SAND1

Gene ID: 84315 | Gene type: protein coding

About MON1A

Cytogenetic location: 3p21.31 Genomic coordinates (GRCh38): 3:49,908,873-49,929,811 (from NCBI)

This gene has 9 transcripts (splice variants), 204 orthologues and 1 paralogue. Ubiquitous expression in duodenum (RPKM 6.4), testis (RPKM 5.1) and 25 other tissues.

Summary

Enables guanyl-nucleotide exchange factor activity. Predicted to be involved in protein secretion. Predicted to act upstream of or within cellular iron ion homeostasis and protein transport. Part of Mon1-Ccz1 complex. [provided by Alliance of Genome Resources, Apr 2022]

MON1A Products(2)

mRNA	Protein	Name
NM_001142501.2	NP_001135973.2	vacuolar fusion protein MON1 homolog A isoform b
NM_032355.4	NP_115731.3	vacuolar fusion protein MON1 homolog A isoform a

Gene Ontology

Molecular Function
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables guanyl-nucleotide exchange factor activity	IDA IDA: Inferred from direct assay	23084991	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23084991	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
part of Mon1-Ccz1 complex	IDA IDA: Inferred from direct assay	29038162	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MON1A Protein Structure

Mon1

0
100
200
300
400
500
600
652 a.a.

Protein Preferred Names

Protein Names

vacuolar fusion protein MON1 homolog A

MON1 secretory trafficking family member A

MON1A Protein-protein interaction Information

Type Cross Intra	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	Reference
Intra	MON1A	Q86VX9	CCZ1	Homo sapiens	P86791	Anti Tag CoIP	23084991
Intra	MON1A	Q86VX9	CCZ1	Homo sapiens	P86791	GDP/GTP Exchange	23084991

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases

Alias

Hermansky-Pudlak Syndrome

Hps	Albinism With Hemorrhagic Diathesis And Pigmented Reticuloendothelial Cells
Hermanski-Pudlak Syndrome	Hermansky Pudlak Syndrome
Platelet Storage Pool Deficiency

Oculomotor Nerve Paralysis

Iii Nerve Palsy	Iiird Nerve Paralysis
Third Cranial Nerve Paralysis

Third Cranial Nerve Disease

Disorder Of Oculomotor Nerve	Oculomotor Nerve Disorder
Oculomotor Nerve Paralysis	Third Cranial Nerve Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS08587	MON1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	MON1A	VGNC	VGNC:63554
Canis familiaris	MON1A	VGNC	VGNC:43313
Bos taurus	MON1A	VGNC	VGNC:31552
Macaca mulatta	MON1A	VGNC	VGNC:74846
Mus musculus	MON1A	MGD	MGI:1920075
Rattus norvegicus	MON1A	RGD	RGD:1308823

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