Ctnnb1 - catenin beta 1 Gene

Rattus norvegicus

Also known as Catnb

Gene ID: 84353 | Gene type: protein coding

About Ctnnb1

Primary_assembly 8: 120,639,995-120,667,111 forward strand.mRatBN7.2:CM026981.1

This gene has 2 transcripts (splice variants), 217 orthologues, 5 paralogues and is associated with 116 phenotypes. Biased expression in Kidney (RPKM 1354.8), Lung (RPKM 133.) and 9 other tissues.

Summary

Enables cadherin binding activity; ionotropic glutamate receptor binding activity; and nitric-oxide synthase binding activity. Involved in several processes, including cellular response to insulin-like growth factor stimulus; cellular response to lithium ion; and cellular response to mechanical stimulus. Located in several cellular components, including dendritic shaft; intercalated disc; and nuclear membrane. Part of protein-containing complex. Colocalizes with neuron projection. Used to study colon adenocarcinoma and lung carcinoma. Biomarker of Alzheimer's disease and colorectal Cancer. Human ortholog(s) of this gene implicated in several diseases, including autosomal dominant non-syndromic intellectual disability 19; exudative vitreoretinopathy 7; hepatocellular carcinoma (multiple); reproductive organ Cancer (multiple); and urinary system Cancer (multiple). Orthologous to human CTNNB1 (catenin beta 1). [provided by Alliance of Genome Resources, Apr 2022]

Ctnnb1 Products(1)

mRNA	Protein	Name
NM_053357.2	NP_445809.2	catenin beta-1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables alpha-catenin binding	IPI IPI: Inferred from physical interaction	12960056	RGD
enables cadherin binding	IDA IDA: Inferred from direct assay	9515794	RGD
enables cadherin binding	IPI IPI: Inferred from physical interaction	12533412	RGD
enables delta-catenin binding	IPI IPI: Inferred from physical interaction	12960056	RGD
enables ionotropic glutamate receptor binding	IPI IPI: Inferred from physical interaction	20007479	RGD
enables nitric-oxide synthase binding	IPI IPI: Inferred from physical interaction	15858215	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8794867	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	8834786	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in Schwann cell proliferation	IMP IMP: Inferred from mutant phenotype	17941050	RGD
involved in bone remodeling	IEP IEP: Inferred from expression pattern	29224185	RGD
involved in cell-cell adhesion	IDA IDA: Inferred from direct assay	12533412	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	12095987	RGD
involved in cellular response to insulin-like growth factor stimulus	IEP IEP: Inferred from expression pattern	20042609	RGD
involved in cellular response to insulin-like growth factor stimulus	IMP IMP: Inferred from mutant phenotype	20042609	RGD
involved in cellular response to lithium ion	IEP IEP: Inferred from expression pattern	12610652	RGD
involved in cellular response to mechanical stimulus	IDA IDA: Inferred from direct assay	20042609	RGD
involved in cellular response to zinc ion starvation	IEP IEP: Inferred from expression pattern	21893222	RGD
involved in epididymis development	IEP IEP: Inferred from expression pattern	12960056	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	17236583	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	17356920	RGD
involved in myoblast differentiation	IEP IEP: Inferred from expression pattern	17222478	RGD
involved in negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	23270756	RGD
involved in odontogenesis of dentin-containing tooth	IEP IEP: Inferred from expression pattern	10681393	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	22252247	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	17136310	RGD
involved in response to cytokine	IDA IDA: Inferred from direct assay	17888912	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	22252247	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	17170212	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	17708712	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	18174280	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in adherens junction	IDA IDA: Inferred from direct assay	8834786	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	12960056	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	12610652	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	12123611	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	25586361	RGD
located in lateral plasma membrane	IDA IDA: Inferred from direct assay	12960056	RGD
located in membrane	IDA IDA: Inferred from direct assay	16815997	RGD
located in nuclear membrane	IDA IDA: Inferred from direct assay	12610652	RGD
located in nucleus	IDA IDA: Inferred from direct assay	16690606	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20042609	RGD
located in plasma membrane	IDA IDA: Inferred from direct assay	12610652	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	12533412	RGD
located in tight junction	IDA IDA: Inferred from direct assay	12960056	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Ctnnb1 Protein Structure

CTNNAbd_CTNNB1

SRP1

ARM

Arm

ARM

Arm

ARM

0
200
400
600
781 a.a.

Protein Preferred Names

Protein Names

catenin beta-1

beta-catenin

catenin (cadherin associated protein), beta 1, 88kDa

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120675	SSTC3		98.65%	Unkown
HY-161719	NF764	Degrader	99.28%	Unkown
HY-160765	WNTinib		99.95%	Unkown
HY-RS03306	CTNNB1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03307	Ctnnb1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS03308	Ctnnb1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ctnnb1	NCBI	NCBI:1499
Mus musculus	Ctnnb1	NCBI	NCBI:12387

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