2. Gene
  3. NIFK - nucleolar protein interacting with the FHA domain of MKI67 Gene

NIFK - nucleolar protein interacting with the FHA domain of MKI67 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as Nopp34; MKI67IP

Gene ID: 84365 | Gene type: protein coding

About NIFK

Cytogenetic location: 2q14.3 Genomic coordinates (GRCh38): 2:121,726,945-121,736,875 (from NCBI)

This gene has 7 transcripts (splice variants) and 205 orthologues. Ubiquitous expression in lymph node (RPKM 19.8), appendix (RPKM 17.9) and 25 other tissues.

Summary

This gene encodes a protein that interacts with the forkhead-associated domain of the Ki-67 antigen. The encoded protein may bind RNA and may play a role in mitosis and cell cycle progression. Multiple pseudogenes exist on chromosomes 5, 10, 12, 15, and 19.[provided by RefSeq, Jan 2009]

NIFK Products(1)

mRNA Protein Name
NM_032390.5 NP_115766.3 MKI67 FHA domain-interacting nucleolar phosphoprotein
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables RNA binding IDA
IDA: Inferred from direct assay
11342549 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
11342549 GOA
Cellular Component GO Annotation Evidence Reference Source
located in condensed nuclear chromosome IDA
IDA: Inferred from direct assay
11342549 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
11342549 GOA
located in nucleolus IDA
IDA: Inferred from direct assay
11342549 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
11342549 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NIFK Protein Structure

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (47 - 116)

hNIFK_binding

hNIFK_binding: FHA Ki67 binding domain of hNIFK (227 - 267)

  • 0
  • 100
  • 200
  • 293 a.a.
Protein Preferred Names Protein Names

MKI67 FHA domain-interacting nucleolar phosphoprotein

hNIFK

NIFK Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra
NIFK Q9BYG3 TNIP1 Homo sapiens Q15025
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09296 NIFK Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus NIFK VGNC VGNC:32076
Rattus norvegicus NIFK RGD RGD:708462
Mus musculus NIFK MGD MGI:1915199
Felis catus NIFK VGNC VGNC:107592
Macaca mulatta NIFK VGNC VGNC:75201
Canis familiaris NIFK VGNC VGNC:43809