2. Gene
  3. TNIP1 - TNFAIP3 interacting protein 1 Gene

TNIP1 - TNFAIP3 interacting protein 1 Gene

  • Gene
  • Protein
  • Disease
  • Agent
  • Ortholog
Homo sapiens

Also known as VAN; NAF1; ABIN-1; nip40-1

Gene ID: 10318 | Gene type: protein coding

About TNIP1

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:151,029,943-151,087,685 (from NCBI)

This gene has 21 transcripts (splice variants), 206 orthologues, 2 paralogues and is associated with 1 phenotype. Ubiquitous expression in fat (RPKM 55.9), spleen (RPKM 36.4) and 25 other tissues.

Summary

This gene encodes an A20-binding protein which plays a role in autoimmunity and tissue homeostasis through the regulation of nuclear factor kappa-B activation. Mutations in this gene have been associated with psoriatic arthritis, rheumatoid arthritis, and systemic lupus erythematosus. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

TNIP1 Products(12)

mRNA Protein Name
NM_001252385.2 NP_001239314.1 TNFAIP3-interacting protein 1 isoform 1
NM_001252386.2 NP_001239315.1 TNFAIP3-interacting protein 1 isoform 2
NM_001252390.2 NP_001239319.1 TNFAIP3-interacting protein 1 isoform 3
NM_001252391.2 NP_001239320.1 TNFAIP3-interacting protein 1 isoform 3
NM_001252392.2 NP_001239321.1 TNFAIP3-interacting protein 1 isoform 4
NM_001252393.2 NP_001239322.1 TNFAIP3-interacting protein 1 isoform 4
NM_001258454.2 NP_001245383.1 TNFAIP3-interacting protein 1 isoform 3
NM_001258455.1 NP_001245384.1 TNFAIP3-interacting protein 1 isoform 5
NM_001258456.1 NP_001245385.1 TNFAIP3-interacting protein 1 isoform 6
NM_001364486.2 NP_001351415.1 TNFAIP3-interacting protein 1 isoform 7
NM_001364487.2 NP_001351416.1 TNFAIP3-interacting protein 1 isoform 5
NM_006058.5 NP_006049.3 TNFAIP3-interacting protein 1 isoform 3
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables identical protein binding IPI
IPI: Inferred from physical interaction
21988832 GOA
enables mitogen-activated protein kinase binding IDA
IDA: Inferred from direct assay
12220502 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15474016 GOA
Biological Process GO Annotation Evidence Reference Source
involved in glycoprotein biosynthetic process IDA
IDA: Inferred from direct assay
9923610 GOA
involved in leukocyte cell-cell adhesion IMP
IMP: Inferred from mutant phenotype
17632516 GOA
involved in negative regulation of ERK1 and ERK2 cascade IDA
IDA: Inferred from direct assay
12220502 GOA
involved in negative regulation of canonical NF-kappaB signal transduction IDA
IDA: Inferred from direct assay
16684768 GOA
involved in positive regulation of protein deubiquitination IDA
IDA: Inferred from direct assay
16684768 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

TNFAIP3-interacting protein 1

A20-binding inhibitor of NF-kappa-B activation 1

TNIP1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Reference
Intra TNIP1 Q15025 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Prey Pooling
32296183
Intra TNIP1 Q15025 KRTAP19-7 Homo sapiens Q3SYF9
Y2H Array
32296183
Intra TNIP1 Q15025 KRTAP19-7 Homo sapiens Q3SYF9
Validated Y2H
32296183
Intra TNIP1 Q15025 SYT6 Homo sapiens Q5T7P8-2
Y2H Array
25416956
Intra TNIP1 Q15025 SYT6 Homo sapiens Q5T7P8-2
Validated Y2H
25416956
Intra TNIP1 Q15025 KRTAP8-1 Homo sapiens Q8IUC2
Validated Y2H
32296183
Intra TNIP1 Q15025 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Array
32296183
Intra TNIP1 Q15025 KRTAP8-1 Homo sapiens Q8IUC2
Y2H Prey Pooling
32296183
Intra TNIP1 Q15025 PNKP Homo sapiens Q96T60
Validated Y2H
32296183
Intra TNIP1 Q15025 GIT2 Homo sapiens Q14161
Y2H
21988832
Intra TNIP1 Q15025 KRTAP19-5 Homo sapiens Q3LI72
Y2H Array
32296183
Intra TNIP1 Q15025 KRTAP19-5 Homo sapiens Q3LI72
Y2H Prey Pooling
32296183
Intra TNIP1 Q15025 KRTAP19-5 Homo sapiens Q3LI72
Validated Y2H
32296183
Intra TNIP1 Q15025 TCEANC Homo sapiens Q8N8B7-2
Validated Y2H
32296183
Intra TNIP1 Q15025 KRTAP6-2 Homo sapiens Q3LI66
Y2H Prey Pooling
32296183
Intra TNIP1 Q15025 KRTAP6-2 Homo sapiens Q3LI66
Validated Y2H
32296183
Intra TNIP1 Q15025 KRTAP6-2 Homo sapiens Q3LI66
Y2H Array
32296183
Intra TNIP1 Q15025 TTF2 Homo sapiens Q9UNY4-2
Validated Y2H
32296183
Intra TNIP1 Q15025 KRTAP19-3 Homo sapiens Q7Z4W3
Validated Y2H
32296183
Intra TNIP1 Q15025 KRTAP6-1 Homo sapiens Q3LI64
Validated Y2H
32296183
Intra TNIP1 Q15025 TTC39A Homo sapiens Q5SRH9-6
Validated Y2H
32296183
Intra TNIP1 Q15025 PIBF1 Homo sapiens Q4G0R1
Validated Y2H
32296183
Intra TNIP1 Q15025 KIFC3 Homo sapiens Q9BVG8-5
Validated Y2H
32296183
Intra TNIP1 Q15025 KIFC3 Homo sapiens Q9BVG8
Validated Y2H
25416956
Intra TNIP1 Q15025 KIFC3 Homo sapiens Q9BVG8
Y2H Array
25416956
Intra TNIP1 Q15025 EHHADH Homo sapiens Q08426
Y2H Array
25416956
Intra TNIP1 Q15025 EHHADH Homo sapiens Q08426
Y2H Array
31515488
Intra TNIP1 Q15025 TNIP3 Homo sapiens Q96KP6
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 TNIP3 Homo sapiens Q96KP6
Validated Y2H
32296183
Intra TNIP1 Q15025 MOB1B Homo sapiens Q7L9L4
Validated Y2H
25416956
Intra TNIP1 Q15025 MOB1B Homo sapiens Q7L9L4
Y2H Array
25416956
Intra TNIP1 Q15025 NIFK Homo sapiens Q9BYG3
Validated Y2H
25416956
Intra TNIP1 Q15025 NIFK Homo sapiens Q9BYG3
Y2H Array
25416956
Intra TNIP1 Q15025 MAP1LC3C Homo sapiens Q9BXW4
Validated Y2H
32296183
Intra TNIP1 Q15025 ZMAT2 Homo sapiens Q96NC0
Validated Y2H
32296183
Intra TNIP1 Q15025 CDIP1 Homo sapiens Q9H305
Y2H Array
25416956
Intra TNIP1 Q15025 CDIP1 Homo sapiens Q9H305
Y2H
21516116
Intra TNIP1 Q15025 CDC37 Homo sapiens Q16543
Validated Y2H
32296183
Intra TNIP1 Q15025 NFKB1 Homo sapiens P19838
Anti Tag CoIP
33961781
Intra TNIP1 Q15025 TSG101 Homo sapiens Q99816
Anti Tag CoIP
33961781
Intra TNIP1 Q15025 TSG101 Homo sapiens Q99816
Validated Y2H
32296183
Intra TNIP1 Q15025 ZNHIT1 Homo sapiens O43257
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 ZNHIT1 Homo sapiens O43257
Validated Y2H
25416956
Intra TNIP1 Q15025 ZNHIT1 Homo sapiens O43257
Y2H Array
25416956
Intra TNIP1 Q15025 MCRS1 Homo sapiens Q96EZ8
Validated Y2H
32296183
Intra TNIP1 Q15025 OPTN Homo sapiens Q96CV9
Anti Tag CoIP
33961781
Intra TNIP1 Q15025 OPTN Homo sapiens Q96CV9
Y2H
21516116
Intra TNIP1 Q15025 OPTN Homo sapiens Q96CV9
Validated Y2H
32296183
Intra TNIP1 Q15025 OPTN Homo sapiens Q96CV9
Y2H Fragment Pooling
23414517
Intra TNIP1 Q15025 OPTN Homo sapiens Q96CV9
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 OPTN Homo sapiens Q96CV9
ViroTrap
30561431
Intra TNIP1 Q15025 OPTN Homo sapiens Q96CV9
Y2H Array
25416956
Intra TNIP1 Q15025 BYSL Homo sapiens Q13895
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 TXLNA Homo sapiens P40222
Validated Y2H
25416956
Intra TNIP1 Q15025 TXLNA Homo sapiens P40222
Y2H Array
25416956
Intra TNIP1 Q15025 TXLNA Homo sapiens P40222
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 MAP1LC3B Homo sapiens Q9GZQ8
Y2H Array
25416956
Intra TNIP1 Q15025 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Intra TNIP1 Q15025 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra TNIP1 Q15025 GTF2B Homo sapiens Q00403
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 CCNG1 Homo sapiens P51959
Y2H Array
25416956
Intra TNIP1 Q15025 CCNG1 Homo sapiens P51959
Validated Y2H
25416956
Intra TNIP1 Q15025 CCNG1 Homo sapiens P51959
Y2H
21516116
Intra TNIP1 Q15025 CCNG1 Homo sapiens P51959
Y2H
21988832
Intra TNIP1 Q15025 CDC23 Homo sapiens Q9UJX2
Validated Y2H
32296183
Intra TNIP1 Q15025 MORF4L1 Homo sapiens Q9UBU8
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 MORF4L1 Homo sapiens Q9UBU8
Validated Y2H
25416956
Intra TNIP1 Q15025 MORF4L1 Homo sapiens Q9UBU8
Y2H Array
25416956
Intra TNIP1 Q15025 MORF4L2 Homo sapiens Q15014
Validated Y2H
25416956
Intra TNIP1 Q15025 MORF4L2 Homo sapiens Q15014
Y2H Array
25416956
Intra TNIP1 Q15025 TNFAIP3 Homo sapiens P21580
ViroTrap
30561431
Intra TNIP1 Q15025 TNFAIP3 Homo sapiens P21580
Y2H
21988832
Intra TNIP1 Q15025 TNFAIP3 Homo sapiens P21580
Y2H Array
25416956
Intra TNIP1 Q15025 TNFAIP3 Homo sapiens P21580
CoIP
11389905
Intra TNIP1 Q15025 TAX1BP1 Homo sapiens Q86VP1
Y2H Prey Pooling
32296183
Intra TNIP1 Q15025 TAX1BP1 Homo sapiens Q86VP1
Validated Y2H
32296183
Intra TNIP1 Q15025 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
25416956
Intra TNIP1 Q15025 TAX1BP1 Homo sapiens Q86VP1
Y2H Array
32296183
Intra TNIP1 Q15025 TAX1BP1 Homo sapiens Q86VP1
ViroTrap
30561431
Intra TNIP1 Q15025 AP1M1 Homo sapiens Q9BXS5
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 AP1M1 Homo sapiens Q9BXS5
Validated Y2H
25416956
Intra TNIP1 Q15025 TCEANC2 Homo sapiens Q96MN5
Y2H Array
25416956
Intra TNIP1 Q15025 TCEANC2 Homo sapiens Q96MN5
Y2H Prey Pooling
25416956
Cross TNIP1 Q15025 ipaH9.8 Shigella flexneri Q8VSC3
Y2H
20010814
Cross TNIP1 Q15025 ipaH9.8 Shigella flexneri Q8VSC3
Anti Tag CoIP
20010814
Intra TNIP1 Q15025 TCEA2 Homo sapiens Q15560
Y2H Array
32296183
Intra TNIP1 Q15025 TCEA2 Homo sapiens Q15560
Validated Y2H
32296183
Intra TNIP1 Q15025 DPPA4 Homo sapiens Q7L190
Validated Y2H
32296183
Intra TNIP1 Q15025 PIN1 Homo sapiens Q13526
Validated Y2H
25416956
Intra TNIP1 Q15025 PIN1 Homo sapiens Q13526
Y2H Array
25416956
Intra TNIP1 Q15025 PIN1 Homo sapiens Q13526
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 C8orf33 Homo sapiens Q9H7E9
Validated Y2H
32296183
Intra TNIP1 Q15025 NDC80 Homo sapiens O14777
Y2H Array
31515488
Intra TNIP1 Q15025 NDC80 Homo sapiens O14777
Y2H Array
29892012
Intra TNIP1 Q15025 FAM161A Homo sapiens Q3B820
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 FAM161A Homo sapiens Q3B820
Validated Y2H
32296183
Intra TNIP1 Q15025 FAM161A Homo sapiens Q3B820
Y2H Array
25416956
Intra TNIP1 Q15025 GABARAPL2 Homo sapiens P60520
Validated Y2H
25416956
Intra TNIP1 Q15025 GABARAPL2 Homo sapiens P60520
Y2H Array
25416956
Intra TNIP1 Q15025 MAP1LC3A Homo sapiens Q9H492
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 MAP1LC3A Homo sapiens Q9H492
Validated Y2H
32296183
Intra TNIP1 Q15025 MAP1LC3A Homo sapiens Q9H492
Y2H Array
25416956
Intra TNIP1 Q15025 DAZAP2 Homo sapiens Q15038
Validated Y2H
32296183
Intra TNIP1 Q15025 LITAF Homo sapiens Q99732
Validated Y2H
32296183
Intra TNIP1 Q15025 LENG8 Homo sapiens Q96PV6
Validated Y2H
32296183
Intra TNIP1 Q15025 ZBTB25 Homo sapiens P24278
Y2H Array
25416956
Intra TNIP1 Q15025 MAGEB18 Homo sapiens Q96M61
Y2H Pooling
16189514
Intra TNIP1 Q15025 MAGEB18 Homo sapiens Q96M61
Validated Y2H
25416956
Intra TNIP1 Q15025 MAGEB18 Homo sapiens Q96M61
Pull Down
16189514
Intra TNIP1 Q15025 SPATA2 Homo sapiens Q9UM82
Validated Y2H
32296183
Intra TNIP1 Q15025 SPATA2 Homo sapiens Q9UM82
Y2H Prey Pooling
32296183
Intra TNIP1 Q15025 SPATA2 Homo sapiens Q9UM82
Y2H Array
32296183
Intra TNIP1 Q15025 NME7 Homo sapiens Q9Y5B8
Validated Y2H
25416956
Intra TNIP1 Q15025 NME7 Homo sapiens Q9Y5B8
Validated Y2H
32296183
Intra TNIP1 Q15025 NME7 Homo sapiens Q9Y5B8
Y2H
21516116
Intra TNIP1 Q15025 NME7 Homo sapiens Q9Y5B8
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 NME7 Homo sapiens Q9Y5B8
Y2H
21988832
Intra TNIP1 Q15025 CCDC112 Homo sapiens Q8NEF3
Validated Y2H
25416956
Intra TNIP1 Q15025 CCDC112 Homo sapiens Q8NEF3
Y2H Array
25416956
Intra TNIP1 Q15025 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
25416956
Intra TNIP1 Q15025 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
32296183
Intra TNIP1 Q15025 VPS33B Homo sapiens Q9H267
Validated Y2H
25416956
Intra TNIP1 Q15025 VPS33B Homo sapiens Q9H267
Validated Y2H
32296183
Intra TNIP1 Q15025 VPS33B Homo sapiens Q9H267
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 RALBP1 Homo sapiens Q15311
Y2H Array
25416956
Intra TNIP1 Q15025 SNIP1 Homo sapiens Q8TAD8
Y2H Array
25416956
Intra TNIP1 Q15025 HDDC3 Homo sapiens Q8N4P3
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 HDDC3 Homo sapiens Q8N4P3
Validated Y2H
25416956
Intra TNIP1 Q15025 HDDC3 Homo sapiens Q8N4P3
Y2H Array
25416956
Intra TNIP1 Q15025 FAM168A Homo sapiens Q92567
Y2H Prey Pooling
25416956
Intra TNIP1 Q15025 FAM168A Homo sapiens Q92567
Validated Y2H
25416956
Intra TNIP1 Q15025 FAM168A Homo sapiens Q92567
Y2H Array
25416956
Intra TNIP1 Q15025 IKBKG Homo sapiens Q9Y6K9
Y2H
21988832
Intra TNIP1 Q15025 MOB3C Homo sapiens Q70IA8
Y2H Array
25416956
Intra TNIP1 Q15025 MOB3C Homo sapiens Q70IA8
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Systemic Lupus Erythematosus

Lupus Nephritis

SLE

Disseminated Lupus Erythematosus

Systemic Lupus Erythematosus, Susceptibility To

Lupus Erythematosus, Systemic

Lupus Nephritis, Susceptibility To

Libman-Sacks Disease

Systemic Lupus Erythematosus Susceptibility To

Sle - Lupus Erythematosus, Systemic

Le Syndrome

Lupus

Lupus Erythematosus Systemic

Lupus Erythematosus, Systemic, Susceptibility To

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus

Systemic Lupus Erythematosus Nos

Sle - [Systemic Lupus Erythematosus]
Psoriatic Arthritis

Psoriatic Arthritis, Susceptibility To

Psoriatic Arthropathy

Arthropathic Psoriasis

Arthritis, Psoriatic

Arthritis Psoriatica

PSORAS

Arthritic Psoriasis

Psoriasis Arthropathica

Arthritis Psoriatic

Arthritis, Psoriatic, Susceptibility To
Lupus Erythematosus

Lupus

Lupus Vulgaris

Lupus Erythematosus, Discoid

Lupus Erythematosus, Systemic

Subacute Cutaneous Lupus

Le - [Lupus Erythematosus]
Rheumatoid Arthritis

RA

Arthritis, Rheumatoid

Rheumatoid Arthritis, Susceptibility To

Arthritis Or Polyarthritis, Rheumatic

Atrophic Arthritis

Rheumatism Arthritis

Rheumatoid Polyarthritis
Arthritis

Inflammatory Joint Disease

Inflammatory Disorder Of Joint
Psoriasis 14, Pustular

Generalized Pustular Psoriasis

Gpp

Ditra

Acrodermatitis Continua Of Hallopeau

Palmoplantar Pustulosis

PSORS14

Interleukin 36 Receptor Antagonist Deficiency

Psorp

Pustular Psoriasis 14

Deficiency Of Il-36r Antagonist

Acute Generalised Pustular Psoriasis

Deficiency Of The Interleukin-36 Receptor Antagonist

Generalized Pustular Psoriasis Of Von Zumbusch

Von Zumbusch Psoriasis

Deficiency Of Il-36ra

Psoriasis, Pustular, Generalized

Psoriasis, Pustular, Type 14

Pustulosis Of Palms And Soles

Acute Generalized Pustular Psoriasis

Palmoplantar Pustular Psoriasis

Pustulosis Palmaris Et Plantaris

Ppp - [Palmoplantar Pustulosis]

Pustular Psoriasis Of The Palms And Soles

Pustular Bacterid
Neural Tube Defects

Spina Bifida

Neural Tube Defect

NTD

Neural Tube Defects, Susceptibility To

Spinal Dysraphism

Spina Bifida, Susceptibility To

Rachischisis

Cleft Spine

Open Spine

Hydrocele Spinalis

Neural Tube Defect Nos

Sb - [Spina Bifida]

Spinal Hernia Nos

Spinal Fissure Nos
Potocki-Shaffer Syndrome

Proximal 11p Deletion Syndrome

Chromosome 11p11.2 Deletion Syndrome

Pss

11p11.2 Deletion

P11pds

Defect11 Syndrome

Deletion Of Chromosome 11p11.2

POSHS
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS14834 TNIP1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Macaca mulatta TNIP1 VGNC VGNC:79057
Bos taurus TNIP1 VGNC VGNC:36180
Canis familiaris TNIP1 VGNC VGNC:47676
Rattus norvegicus TNIP1 RGD RGD:1309380
Mus musculus TNIP1 MGD MGI:1926194
Felis catus TNIP1 VGNC VGNC:66416