1. Gene
  2. PROK1 - prokineticin 1 Gene

PROK1 - prokineticin 1 Gene

Homo sapiens

Also known as PK1; PRK1; EGVEGF

Gene ID: 84432 | Gene type: protein coding

About PROK1

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:110,451,149-110,457,358 (from NCBI)

This gene has 1 transcript (splice variant), 190 orthologues and 1 paralogue. Biased expression in ovary (RPKM 72.8), testis (RPKM 51.2) and 2 other tissues.

Summary

The protein encoded by this gene induces proliferation, migration, and fenestration (the formation of membrane discontinuities) in capillary endothelial cells derived from endocrine glands. It has little or no effect on a variety of other endothelial and non-endothelial cell types. Its expression is restricted to the steroidogenic glands (ovary, testis, adrenal, and placenta), is induced by hypoxia, and often complementary to the expression of vascular endothelial growth factor (VEGF), suggesting that these molecules function in a coordinated manner. [provided by RefSeq, Sep 2011]

PROK1 Products(1)

mRNA Protein Name
NM_032414.3 NP_115790.1 prokineticin-1 precursor

PROK1 Protein Structure

Prokineticin

Prokineticin: Prokineticin (1 - 97)

  • 0
  • 105 a.a.
Protein Preferred Names Protein Names

prokineticin-1

EG-VEGF

Recombinant PROK1 Proteins

Cat. No. Product Name Accession Purity
HY-P74616 Prokineticin-1/EG-VEGF Protein, Human (sf9, His) P58294 (A20-F105) ≥95%

Related Diseases

Diseases Alias
Neuroblastoma

Nb

Neuroblastoma, Susceptibility To

Neuroblastomas

Central Neuroblastoma

Endocervicitis
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia

Hirschsprung Disease 1

Hirschsprung Disease

Aganglionic Megacolon

Hscr

Hirschsprung'S Disease

Congenital Megacolon

Congenital Intestinal Aganglionosis

Colonic Aganglionosis

Hirschsprung Disease, Susceptibility To, 1

Hirschsprung Disease, Protection Against

HSCR1

Mgc

Pelvirectal Achalasia

Total Intestinal Aganglionosis

Megacolon, Aganglionic

Macrocolon

Hscr 1

Hirschsprung Disease Type 1

Hirschsprung Disease, Type 1

Congenital Dilatation Of Colon

Aganglionosis

Congenital Aganglionic Megacolon

Aganglionosis Of Colon

Bowel Aganglionosis

Colon Aganglionosis

Hirschsprung Megacolon

Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Orthologs Information

Species Symbol Source ID
Mus musculus PROK1 MGD MGI:2180370
Macaca mulatta PROK1 VGNC VGNC:76284
Felis catus PROK1 VGNC VGNC:80324
Rattus norvegicus PROK1 RGD RGD:620898
Canis familiaris PROK1 VGNC VGNC:45010
Bos taurus PROK1 VGNC VGNC:33361
Others PROK1 NCBI