Ran - RAN, member RAS oncogene family Gene

Rattus norvegicus

Gene ID: 84509 | Gene type: protein coding

About Ran

Summary

Enables several functions, including dynein intermediate chain binding activity; guanyl ribonucleotide binding activity; and importin-alpha family protein binding activity. Involved in several processes, including cellular response to mineralocorticoid stimulus; hippocampus development; and spermatid development. Located in several cellular components, including male germ cell nucleus; manchette; and sperm flagellum. Part of nuclear pore. Used to study sciatic neuropathy. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Ran Products(1)

mRNA	Protein	Name
NM_053439.2	NP_445891.1	GTP-binding nuclear protein Ran

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables GDP binding	IDA IDA: Inferred from direct assay	19505478	RGD
enables GTP binding	IDA IDA: Inferred from direct assay	19505478	RGD
enables dynein intermediate chain binding	IDA IDA: Inferred from direct assay	18667152	RGD
enables importin-alpha family protein binding	IDA IDA: Inferred from direct assay	18667152	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8918934	RGD
enables protein domain specific binding	IPI IPI: Inferred from physical interaction	19505478	RGD
enables protein-containing complex binding	IPI IPI: Inferred from physical interaction	9398662	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to mineralocorticoid stimulus	IEP IEP: Inferred from expression pattern	22811487	RGD
involved in hippocampus development	IEP IEP: Inferred from expression pattern	18493952	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16003757	RGD
involved in spermatid development	IEP IEP: Inferred from expression pattern	12211070	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in male germ cell nucleus	IDA IDA: Inferred from direct assay	11870094	RGD
located in manchette	IDA IDA: Inferred from direct assay	12211070	RGD
part of nuclear pore	IDA IDA: Inferred from direct assay	9398662	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	19505478	RGD
located in sperm flagellum	IDA IDA: Inferred from direct assay	12211070	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

GTP-binding nuclear protein Ran

GTPase Ran	ras-like protein TC4
ras-related nuclear protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-W141374	CB096		/	Unkown
HY-120743	Triplin		/	Unkown
HY-125964	LLP-3	Inhibitor	/	Unkown
HY-173350	Ran-IN-1	Inhibitor	/	Unkown
HY-RS11641	RAN Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-W250191	Tergitol		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ran	NCBI	NCBI:5901
Canis familiaris	Ran	NCBI	NCBI:100499482
Macaca fascicularis	Ran	NCBI	NCBI:102133660
Mus musculus	Ran	NCBI	NCBI:19384
Susscrofa domestica	Ran	NCBI
Leporidae	Ran	NCBI
Macaca mulatta	Ran	NCBI	NCBI:709200

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