2. Gene
  3. Ran - RAN, member RAS oncogene family Gene

Ran - RAN, member RAS oncogene family Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 19384 | Gene type: protein coding

About Ran

Summary

Predicted to enable several functions, including dynein intermediate chain binding activity; guanyl ribonucleotide binding activity; and importin-alpha family protein binding activity. Predicted to contribute to pre-miRNA binding activity. Acts upstream of or within actin Cytoskeleton organization; protein import into nucleus; and protein-containing complex localization. Located in cytoplasm and nuclear envelope. Is expressed in several structures, including branchial arch; central nervous system; extraembryonic component; hemolymphoid system gland; and sensory organ. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human RAN (RAN, member Ras oncogene family). [provided by Alliance of Genome Resources, Apr 2022]

Ran Products(1)

mRNA Protein Name
NM_009391.3 NP_033417.1 GTP-binding nuclear protein Ran
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
11809816 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within actin cytoskeleton organization IMP
IMP: Inferred from mutant phenotype
21874009 MGI
acts upstream of or within protein import into nucleus IDA
IDA: Inferred from direct assay
11809816 MGI
acts upstream of or within protein localization IMP
IMP: Inferred from mutant phenotype
21874009 MGI
acts upstream of or within protein-containing complex localization IMP
IMP: Inferred from mutant phenotype
21874009 MGI
Cellular Component GO Annotation Evidence Reference Source
located in cytoplasm IDA
IDA: Inferred from direct assay
18347012 MGI
located in nuclear envelope IDA
IDA: Inferred from direct assay
25946333 MGI
located in nucleus IDA
IDA: Inferred from direct assay
18347012 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GTP-binding nuclear protein Ran

GTPase Ran

ras-like protein TC4

ras-related nuclear protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-120743 Triplin / Unkown
HY-125964 LLP-3 Inhibitor / Unkown
HY-RS11641 RAN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-W141374 CB096 / Unkown
HY-W250191 Tergitol / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ran NCBI NCBI:5901
Canis familiaris Ran NCBI NCBI:100499482
Macaca fascicularis Ran NCBI NCBI:102133660
Susscrofa domestica Ran NCBI
Leporidae Ran NCBI
Rattus norvegicus Ran NCBI NCBI:84509
Macaca mulatta Ran NCBI NCBI:709200