GLYR1 - glyoxylate reductase 1 homolog Gene

Homo sapiens

Also known as NP60; NPAC; hNDF; BM045; HIBDL; N-PAC

Gene ID: 84656 | Gene type: protein coding

About GLYR1

Cytogenetic location: 16p13.3 Genomic coordinates (GRCh38): 16:4,803,203-4,847,288 (from NCBI)

This gene has 13 transcripts (splice variants), 207 orthologues and 1 paralogue. Ubiquitous expression in kidney (RPKM 24.0), brain (RPKM 23.5) and 25 other tissues.

Summary

Enables DNA binding activity; methylated histone binding activity; and nucleosome binding activity. Involved in positive regulation of histone acetylation and positive regulation of transcription by RNA polymerase II. Located in cytosol and nucleoplasm. Part of nucleosome. [provided by Alliance of Genome Resources, Apr 2022]

GLYR1 Products(5)

mRNA	Protein	Name
NM_001308096.2	NP_001295025.1	cytokine-like nuclear factor N-PAC isoform 2
NM_001324096.2	NP_001311025.2	cytokine-like nuclear factor N-PAC isoform 3
NM_001324097.2	NP_001311026.2	cytokine-like nuclear factor N-PAC isoform 4
NM_001324098.2	NP_001311027.2	cytokine-like nuclear factor N-PAC isoform 5
NM_032569.4	NP_115958.2	cytokine-like nuclear factor N-PAC isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	29759984	GOA
enables chromatin binding	IDA IDA: Inferred from direct assay	29759984	GOA
enables chromatin-protein adaptor activity	IDA IDA: Inferred from direct assay	30970244	GOA
enables histone binding	IDA IDA: Inferred from direct assay	23260659	GOA
enables methylated histone binding	IDA IDA: Inferred from direct assay	20850016	GOA
enables nucleosome binding	IDA IDA: Inferred from direct assay	29759984	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	23260659	GOA

Biological Process GO Annotation	Evidence	Reference	Source
involved in transcription elongation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	29759984	GOA
involved in transcription initiation-coupled chromatin remodeling	IDA IDA: Inferred from direct assay	30970244	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in chromatin	IDA IDA: Inferred from direct assay	30970244	GOA
part of nucleosome	IDA IDA: Inferred from direct assay	23260659	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GLYR1 Protein Structure

PWWP

NAD_binding_2

NAD_binding_11

0
100
200
300
400
500
553 a.a.

Protein Preferred Names

Protein Names

cytokine-like nuclear factor N-PAC

3-hydroxyisobutyrate dehydrogenase-like protein

Related Diseases

Diseases

Alias

Retinitis Pigmentosa 47

RP47	Retinitis Pigmentosa, Type 47

Ritscher-Schinzel Syndrome

3c Syndrome	Ccc Dysplasia
Craniocerebellocardiac Dysplasia	Cranio-Cerebello-Cardiac Dysplasia

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-41700	D-Alanine		99.80%	Unkown
HY-161246	uPSEM792		99.92%	Unkown
HY-41700S2	D-Alanine-d1		/	Unkown
HY-RS05512	GLYR1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	GLYR1	VGNC	VGNC:29430
Canis familiaris	GLYR1	VGNC	VGNC:41284
Macaca mulatta	GLYR1	VGNC	VGNC:99510
Rattus norvegicus	GLYR1	RGD	RGD:1309459
Mus musculus	GLYR1	MGD	MGI:1921272
Felis catus	GLYR1	VGNC	VGNC:62602

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